Temporal scaling of motor cortical dynamics reveals hierarchical control of vocal production

Banerjee, Arkarup, Chen, Feng, Druckmann, Shaul, Long, Michael A (January 2024) Temporal scaling of motor cortical dynamics reveals hierarchical control of vocal production. Nature Neuroscience. ISSN 1097-6256

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Abstract

Neocortical activity is thought to mediate voluntary control over vocal production, but the underlying neural mechanisms remain unclear. In a highly vocal rodent, the male Alston's singing mouse, we investigate neural dynamics in the orofacial motor cortex (OMC), a structure critical for vocal behavior. We first describe neural activity that is modulated by component notes (~100 ms), probably representing sensory feedback. At longer timescales, however, OMC neurons exhibit diverse and often persistent premotor firing patterns that stretch or compress with song duration (~10 s). Using computational modeling, we demonstrate that such temporal scaling, acting through downstream motor production circuits, can enable vocal flexibility. These results provide a framework for studying hierarchical control circuits, a common design principle across many natural and artificial systems.

Item Type:	Paper
Subjects:	organism description > animal organism description > animal > mammal organs, tissues, organelles, cell types and functions > tissues types and functions > motor cortex organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Banerjee, Arkarup
Communities:	CSHL labs > Banerjee lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	30 January 2024
Date Deposited:	31 Jan 2024 14:30
Last Modified:	31 Jan 2024 14:30
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41426

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