Using Animal Models for Gender-Affirming Hormone Therapy

Aghi, K, Goetz, TG, Pfau, DR, Sun, SD, Guthman, EM, Roepke, TA (January 2024) Using Animal Models for Gender-Affirming Hormone Therapy. Journal of the Endocrine Society, 8 (1). ISSN 2472-1972

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Abstract

We have recently proposed experimental design guidelines and areas of study for preclinical rodent models of gender-affirming hormone therapy in neuroscience. These guidelines also apply to any field subject to the influences of gonadal steroid hormones, including metabolism and growth, cancer, and physiology. This perspective briefly describes our suggestions for these fields. Studying the effects of exogenous steroid hormones will have translational benefits for the community. We also discuss the need for equitable practices for cisgender scientists who wish to implement these guidelines and engage with the community. It is necessary that community-informed practices are implemented in preclinical research to maximize the benefit to transgender, nonbinary, and/or gender diverse (TNG) healthcare, which is currently in jeopardy in the United States, Europe, and across the globe.

Item Type:	Paper
Subjects:	bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > hormones organism description > model organism bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:	Sun, Simón(e)
Communities:	CSHL labs > Tollkuhn lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	1 January 2024
Date Deposited:	05 Jan 2024 14:16
Last Modified:	11 Jan 2024 14:05
PMCID:	PMC10714898
Related URLs:	Publisher PubMed
URI:	https://repository.cshl.edu/id/eprint/41392

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