Leiomyosarcoma: One disease or distinct biologic entities based on site of origin?

Worhunsky, David J, Gupta, Mihir, Gholami, Sepideh, Tran, Thuy B, Ganjoo, Kristen N, van de Rijn, Matt, Visser, Brendan C, Norton, Jeffrey A, Poultsides, George A (June 2015) Leiomyosarcoma: One disease or distinct biologic entities based on site of origin? Journal of Surgical Oncology, 111 (7). pp. 808-812. ISSN 0022-4790

URL: https://www.ncbi.nlm.nih.gov/pubmed/25920434
DOI: 10.1002/jso.23904


BACKGROUND: Leiomyosarcoma (LMS) can originate from the retroperitoneum, uterus, extremity, and trunk. It is unclear whether tumors of different origin represent discrete entities. We compared clinicopathologic features and outcomes following surgical resection of LMS stratified by site of origin. METHODS: Patients with LMS undergoing resection at a single institution were retrospectively reviewed. Clinicopathologic variables were compared across sites. Survival was calculated using the Kaplan-Meier method and compared using log-rank and Cox regression analyses. RESULTS: From 1983 to 2011, 138 patients underwent surgical resection for LMS. Retroperitoneal and uterine LMS were larger, higher grade, and more commonly associated with synchronous metastases. However, disease-specific survival, recurrence-free survival, and recurrence patterns were not significantly different across the four sites. Synchronous metastases (HR 3.20, P < 0.001), but not site of origin, size, grade, or margin status, were independently associated with worse DSS. A significant number of recurrences and disease-related deaths were noted beyond 5 years. CONCLUSIONS: Although larger and higher grade, retroperitoneal and uterine LMS share similar survival and recurrence patterns with their trunk and extremity counterparts. LMS of various anatomic sites may not represent distinct disease processes based on clinical outcomes. The presence of metastatic disease remains the most important prognostic factor for LMS.

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > sarcoma
CSHL Authors:
Communities: CSHL labs > Gholami Lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: June 2015
Date Deposited: 05 Oct 2023 19:37
Last Modified: 05 Oct 2023 19:37
Related URLs:
URI: https://repository.cshl.edu/id/eprint/41150

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