Long-range connectome of pyramidal neurons in the sensorimotor cortex

Yao, M, Tudi, A, Jiang, T, An, X, Sun, Q, Li, A, Huang, ZJ, Gong, H, Li, X (April 2023) Long-range connectome of pyramidal neurons in the sensorimotor cortex. iScience, 26 (4). p. 106316. ISSN 2589-0042

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Abstract

The neocortex mediates information processing through highly organized circuitry that contains various neuron types. Distinct populations of projection neurons in different cortical regions and layers make specific connections and participate in distinct physiological functions. Herein, with the fluorescence micro-optical sectioning tomography (fMOST) and transgenetic mice that targeted intratelencephalic (IT) and pyramidal tract (PT) neurons at specific layers, we dissected the long-range connectome of pyramidal neurons in six subregions of the sensorimtor cortex. The distribution of the input neurons indicated that IT and PT neurons in the same region received information from similar regions, while the neurons in different subregions received from the preferred neuron populations. Both the input and projection areas of these six subregions showed the transverse and longitudinal correspondence in the cortico-cortical, cortico-thalamic, and cortico-striatal circuits, which indicated that the connections were topologically organized. This study provides a comprehensive resource on the anatomical connections of cortical circuits.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > organs types and functions > brain organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Huang, Z. Josh
Communities:	CSHL labs > Huang lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	21 April 2023
Date Deposited:	29 Sep 2023 15:28
Last Modified:	11 Jan 2024 14:59
PMCID:	PMC10033995
Related URLs:	Publisher PubMed
URI:	https://repository.cshl.edu/id/eprint/41058

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