Buchanan, JoAnn, da Costa, Nuno Maçarico, Cheadle, Lucas (August 2023) Emerging roles of oligodendrocyte precursor cells in neural circuit development and remodeling. Trends in Neurosciences, 46 (8). pp. 628-639. ISSN 0166-2236
PDF
2023_Buchanan_Emerging_roles_of_oligodendrocyte_precursor.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (2MB) |
Abstract
Oligodendrocyte precursor cells (OPCs) are non-neuronal brain cells that give rise to oligodendrocytes, glia that myelinate the axons of neurons in the brain. Classically known for their contributions to myelination via oligodendrogenesis, OPCs are increasingly appreciated to play diverse roles in the nervous system, ranging from blood vessel formation to antigen presentation. Here, we review emerging literature suggesting that OPCs may be essential for the establishment and remodeling of neural circuits in the developing and adult brain via mechanisms that are distinct from the production of oligodendrocytes. We discuss the specialized features of OPCs that position these cells to integrate activity-dependent and molecular cues to shape brain wiring. Finally, we place OPCs within the context of a growing field focused on understanding the importance of communication between neurons and glia in the contexts of both health and disease.
Actions (login required)
Administrator's edit/view item |