Optimizing the Diagnosis and Biomarker Testing for Patients with Intrahepatic Cholangiocarcinoma: A Multidisciplinary Approach

Cho, May T, Gholami, Sepideh, Gui, Dorina, Tejaswi, Sooraj L, Fananapazir, Ghaneh, Abi-Jaoudeh, Nadine, Jutric, Zeljka, Samarasena, Jason B, Li, Xiaodong, Valerin, Jennifer B, Mercer, Jacob, Dayyani, Farshid (January 2022) Optimizing the Diagnosis and Biomarker Testing for Patients with Intrahepatic Cholangiocarcinoma: A Multidisciplinary Approach. Cancers, 14 (2). p. 392. ISSN 2072-6694

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Abstract

Cholangiocarcinoma (CCA) is a heterogenous group of malignancies originating in the biliary tree, and associated with poor prognosis. Until recently, treatment options have been limited to surgical resection, liver-directed therapies, and chemotherapy. Identification of actionable genomic alterations with biomarker testing has revolutionized the treatment paradigm for these patients. However, several challenges exist to the seamless adoption of precision medicine in patients with CCA, relating to a lack of awareness of the importance of biomarker testing, hurdles in tissue acquisition, and ineffective collaboration among the multidisciplinary team (MDT). To identify gaps in standard practices and define best practices, multidisciplinary hepatobiliary teams from the University of California (UC) Davis and UC Irvine were convened; discussions of the meeting, including optimal approaches to tissue acquisition for diagnosis and biomarker testing, communication among academic and community healthcare teams, and physician education regarding biomarker testing, are summarized in this review.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders Investigative techniques and equipment Investigative techniques and equipment > assays Investigative techniques and equipment > biomarker Investigative techniques and equipment > assays > next generation sequencing
CSHL Authors:	Gholami, Sepideh
Communities:	CSHL labs > Gholami Lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	13 January 2022
Date Deposited:	27 Sep 2023 20:15
Last Modified:	11 Jan 2024 19:20
PMCID:	PMC8773504
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41017

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