Visual intracortical and transthalamic pathways carry distinct information to cortical areas

Blot, Antonin, Roth, Morgane M, Gasler, Ioana, Javadzadeh, Mitra, Imhof, Fabia, Hofer, Sonja B (June 2021) Visual intracortical and transthalamic pathways carry distinct information to cortical areas. Neuron, 109 (12). 1996-2008.e6. ISSN 0896-6273

PDF 2021_Blot_Visual_Intracortical_and_Transthalamic_Pathways.pdf - Published Version Available under License Creative Commons Attribution. Download (3MB)

Abstract

Sensory processing involves information flow between neocortical areas, assumed to rely on direct intracortical projections. However, cortical areas may also communicate indirectly via higher-order nuclei in the thalamus, such as the pulvinar or lateral posterior nucleus (LP) in the visual system of rodents. The fine-scale organization and function of these cortico-thalamo-cortical pathways remains unclear. We find that responses of mouse LP neurons projecting to higher visual areas likely derive from feedforward input from primary visual cortex (V1) combined with information from many cortical and subcortical areas, including superior colliculus. Signals from LP projections to different higher visual areas are tuned to specific features of visual stimuli and their locomotor context, distinct from the signals carried by direct intracortical projections from V1. Thus, visual transthalamic pathways are functionally specific to their cortical target, different from feedforward cortical pathways, and combine information from multiple brain regions, linking sensory signals with behavioral context.

Item Type:	Paper
Subjects:	organism description > animal organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > tissues types and functions > thalamus organs, tissues, organelles, cell types and functions > tissues types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:	Javadzadeh, Mitra
Communities:	CSHL labs > Javadzadeh lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	16 June 2021
Date Deposited:	26 Sep 2023 19:01
Last Modified:	17 Jan 2024 20:22
PMCID:	PMC8221812
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/40992

Actions (login required)

Administrator's edit/view item