Central Network Dynamics Regulating Visceral and Humoral Functions

Valentino, Rita J, Guyenet, Patrice, Hou, Xun Helen, Herman, Melissa (November 2017) Central Network Dynamics Regulating Visceral and Humoral Functions. The Journal of Neuroscience, 37 (45). pp. 10848-10854. ISSN 0270-6474

Abstract

The brain processes information from the periphery and regulates visceral and immune activity to maintain internal homeostasis, optimally respond to a dynamic external environment, and integrate these functions with ongoing behavior. In addition to its relevance for survival, this integration underlies pathology as evidenced by diseases exhibiting comorbid visceral and psychiatric symptoms. Advances in neuroanatomical mapping, genetically specific neuronal manipulation, and neural network recording are overcoming the challenges of dissecting complex circuits that underlie this integration and deciphering their function. Here we focus on reciprocal communication between the brain and urological, gastrointestinal, and immune systems. These studies are revealing how autonomic activity becomes integrated into behavior as part of a social strategy, how the brain regulates innate immunity in response to stress, and how drugs impact emotion and gastrointestinal function. These examples highlight the power of the functional organization of circuits at the interface of the brain and periphery.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell
neurobiology > neuroscience
neurobiology > neuroscience > systems neuroscience
CSHL Authors:
Communities: CSHL labs > Hou lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 8 November 2017
Date Deposited: 10 May 2022 14:12
Last Modified: 10 May 2022 14:12
PMCID: PMC5678017
URI: https://repository.cshl.edu/id/eprint/40605

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