Predicting flows through microfluidic circuits with fluid walls.

Deroy, Cyril, Stovall-Kurtz, Nicholas, Nebuloni, Federico, Soitu, Cristian, Cook, Peter R, Walsh, Edmond J (2021) Predicting flows through microfluidic circuits with fluid walls. Microsystems and Nanoengineering, 7 (1). p. 93. ISSN 2055-7434

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DOI: 10.1038/s41378-021-00322-6


The aqueous phase in traditional microfluidics is usually confined by solid walls; flows through such systems are often predicted accurately. As solid walls limit access, open systems are being developed in which the aqueous phase is partly bounded by fluid walls (interfaces with air or immiscible liquids). Such fluid walls morph during flow due to pressure gradients, so predicting flow fields remains challenging. We recently developed a version of open microfluidics suitable for live-cell biology in which the aqueous phase is confined by an interface with an immiscible and bioinert fluorocarbon (FC40). Here, we find that common medium additives (fetal bovine serum, serum replacement) induce elastic no-slip boundaries at this interface and develop a semi-analytical model to predict flow fields. We experimentally validate the model's accuracy for single conduits and fractal vascular trees and demonstrate how flow fields and shear stresses can be controlled to suit individual applications in cell biology.

Item Type: Paper
CSHL Authors:
Communities: CSHL labs > Zador lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 2021
Date Deposited: 06 Dec 2021 14:37
Last Modified: 06 Dec 2021 14:37
PMCID: PMC8599700

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