Lateral Hypothalamic Control of Sleep in the Context of Cancer

Borniger, JC, Nevárez, N (January 2020) Lateral Hypothalamic Control of Sleep in the Context of Cancer. In: Neurological Modulation of Sleep: Mechanisms and Function of Sleep Health. Elsevier, pp. 111-124. ISBN 9780128166581

DOI: 10.1016/B978-0-12-816658-1.00012-0


Sleep plays a vital role in health and well-being. Its conservation along nearly all branches of the phylogenetic tree suggests that sleep serves an essential biological function. Disrupted or truncated sleep is consistently linked to heart disease, depression, obesity, and more recently, cancer. Indeed, chronic sleep disturbance affects 10%-20% of the population in the developed world, representing a substantial public health problem that translates into an estimated financial burden in the hundreds of billions of dollars annually. Poor sleep is a strong predictor of subsequent mortality in cancer patients even when taking into consideration other risk factors including age, hormone receptor status, cortisol concentrations, depression, and metastatic spread. Despite the prevalence of these problems, the underlying mechanisms mediating cancer-associated changes in sleep are unknown. Here, we discuss recent evidence supporting a cross-talk among tumors in the periphery, the nervous, endocrine, metabolic, and immune systems leading to sleep and systemic disruption. Special emphasis is given to the lateral hypothalamus, which contains many neural populations that couple sleep to metabolic state, immune status, and the environment. Among these, hypocretin/orexin neurons have been the most well characterized. We further lay down logical "next-steps" in this research area that are likely to drive the development of novel treatments for cancer-associated sleep disruption.

Item Type: Book Section
Subjects: diseases & disorders > cancer
diseases & disorders > mental disorders > sleep disorders
organs, tissues, organelles, cell types and functions > tissues types and functions > suprachiasmatic nucleus > hypothalamus
organs, tissues, organelles, cell types and functions > tissues types and functions > hypothalamus
CSHL Authors:
Communities: CSHL labs > Borniger lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 16 January 2020
Date Deposited: 07 May 2021 18:44
Last Modified: 07 May 2021 18:44

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