Reciprocal Regulation of Circadian Rhythms and Immune Function

Borniger, Jeremy C., Cisse, Yasmine-Marie, Surbhi, , Nelson, R. J. (June 2017) Reciprocal Regulation of Circadian Rhythms and Immune Function. Current Sleep Medicine Reports, 3 (2). pp. 93-103.

DOI: 10.1007/s40675-017-0070-7

Abstract

Although several papers have described circadian regulation of the immune function, our goal is to address the reciprocal interactions between the circadian and immune systems. Timekeeping mechanisms have evolved to regulate energy balance in the face of predictable environmental changes. Mounting an immune response is energetically expensive; thus, it is beneficial to allocate resources to immunity when potential exposure to pathogens is highest. Temporally gated activities such as social interactions and eating coincide with increased pathogen exposure. Therefore, many components of immunity are regulated by the circadian system to maximize energy efficiencies. Reciprocally, it is beneficial for immune status to inform the circadian system to ensure adequate rest and recovery from infection and injury. Although the mechanisms controlling these processes remain unspecified, it is a critical relationship important for health and disease. We highlight several examples of circadian gating of immune function. We further discuss the bidirectional pathways through which circadian disruption via light at night, jet lag, shift work, and sleep disruption contribute to reduced immune capacity, and how immune challenge can, in turn, alter circadian function.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > biological clock
diseases & disorders > inflammation > cytokines
CSHL Authors:
Communities: CSHL labs > Borniger lab
Depositing User: Adrian Gomez
Date: June 2017
Date Deposited: 06 Jan 2020 16:00
Last Modified: 06 Jan 2020 16:00
Related URLs:
URI: https://repository.cshl.edu/id/eprint/38877

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