Acute dim light at night increases body mass, alters metabolism, and shifts core body temperature circadian rhythms

Borniger, J. C., Maurya, S. K., Periasamy, M., Nelson, R. J. (October 2014) Acute dim light at night increases body mass, alters metabolism, and shifts core body temperature circadian rhythms. Chronobiol Int, 31 (8). pp. 917-25. ISSN 1525-6073 (Electronic)0742-0528 (Linking)

DOI: 10.3109/07420528.2014.926911


The circadian system is primarily entrained by the ambient light environment and is fundamentally linked to metabolism. Mounting evidence suggests a causal relationship among aberrant light exposure, shift work, and metabolic disease. Previous research has demonstrated deleterious metabolic phenotypes elicited by chronic (>4 weeks) exposure to dim light at night (DLAN) ( approximately 5 lux). However, the metabolic effects of short-term (<2 weeks) exposure to DLAN are unspecified. We hypothesized that metabolic alterations would arise in response to just 2 weeks of DLAN. Specifically, we predicted that mice exposed to dim light would gain more body mass, alter whole body metabolism, and display altered body temperature (Tb) and activity rhythms compared to mice maintained in dark nights. Our data largely support these predictions; DLAN mice gained significantly more mass, reduced whole body energy expenditure, increased carbohydrate over fat oxidation, and altered temperature circadian rhythms. Importantly, these alterations occurred despite similar activity locomotor levels (and rhythms) and total food intake between groups. Peripheral clocks are potently entrained by body temperature rhythms, and the deregulation of body temperature we observed may contribute to metabolic problems due to "internal desynchrony" between the central circadian oscillator and temperature sensitive peripheral clocks. We conclude that even relatively short-term exposure to low levels of nighttime light can influence metabolism to increase mass gain.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > biological clock
organs, tissues, organelles, cell types and functions > organs types and functions > metabolism
organism description > animal > mammal > rodent > mouse
CSHL Authors:
Communities: CSHL labs > Borniger lab
Depositing User: Adrian Gomez
Date: October 2014
Date Deposited: 03 Jan 2020 18:55
Last Modified: 03 Jan 2020 18:55
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