Future Promises and Concerns of Ubiquitous Next-Generation Sequencing

McCombie, W. R., McPherson, J. D. (November 2018) Future Promises and Concerns of Ubiquitous Next-Generation Sequencing. Cold Spring Harb Perspect Med, 9 (9). ISSN 2157-1422

URL: https://www.ncbi.nlm.nih.gov/pubmed/30478095
DOI: 10.1101/cshperspect.a025783


Since the first draft of the human genome was completed, next-generation DNA sequencing technology has dramatically reduced the cost of sequencing a genome. Computational analysis has not advanced as fast as the instruments that generate the data, and storing all the data remains a challenge. Nevertheless, personal genomics has arrived and is already being used in the clinic. Significant privacy issues remain, however, and these are not widely understood. The Genetic Information Non-Discrimination Act (GINA) needs to be extended and the probabilistic nature of genetic predisposition must be better explained to both the public and physicians. We must also be wary that this promising new technology and its applications do not amplify existing healthcare disparities.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics
Investigative techniques and equipment > assays > next generation sequencing
CSHL Authors:
Communities: CSHL labs > McCombie lab
Depositing User: Matthew Dunn
Date: 26 November 2018
Date Deposited: 20 Dec 2018 16:18
Last Modified: 14 Dec 2020 16:39
PMCID: PMC6719590
Related URLs:
URI: https://repository.cshl.edu/id/eprint/37494

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