Direct Diagnostic Tests for Lyme Disease

Schutzer, S. E., Body, B. A., Boyle, J., Branson, B. M., Dattwyler, R. J., Fikrig, E., Gerald, N. J., Gomes-Solecki, M., Kintrup, M., Ledizet, M., Levin, A. E., Lewinski, M., Liotta, L. A., Marques, A., Mead, P. S., Mongodin, E. F., Pillai, S., Rao, P., Robinson, W. H., Roth, K. M., Schriefer, M. E., Slezak, T., Snyder, J. L., Steere, A. C., Witkowski, J., Wong, S. J., Branda, J. A. (October 2018) Direct Diagnostic Tests for Lyme Disease. Clin Infect Dis, 68 (6). pp. 1052-1057. ISSN 1058-4838

DOI: 10.1093/cid/ciy614


Borrelia burgdorferi was discovered to be the cause of Lyme disease in 1983, leading to seroassays. The 1994 serodiagnostic testing guidelines predated a full understanding of key B. burgdorferi antigens and have a number of shortcomings. These serologic tests cannot distinguish active infection, past infection, or reinfection. Reliable direct-detection methods for active B. burgdorferi infection have been lacking in the past but are needed and appear achievable. New approaches have effectively been applied to other emerging infections and show promise in direct detection of B. burgdorferi infections.

Item Type: Paper
Subjects: diseases & disorders > Bacterial Infections > Lyme disease
Investigative techniques and equipment > serology
CSHL Authors:
Communities: Banbury Center
Depositing User: Matthew Dunn
Date: 11 October 2018
Date Deposited: 18 Oct 2018 15:31
Last Modified: 07 May 2020 14:28
PMCID: PMC6399434
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