Effect of volume used for injection in micro-assay of prolactin

Bates, Robert Wesley, Riddle, Oscar (1940) Effect of volume used for injection in micro-assay of prolactin. Proceedings of the Society for Experimental Biology and Medicine, 44. pp. 505-509.

URL: http://journals.sagepub.com/doi/pdf/10.3181/003797...


In 2 types (single and double injection) of 48-hour micro-methods for assaying prolactin, in which the injection volume was 0.05 ml, 4 times as much prolactin was required for minimum stimulation as when the volume was 10 times larger, 0.5 ml. A minimum stimulation dose of prolactin in 0.05 nil thus has its apparent effectiveness increased 4 times by a dilution of 10 times. No simple explanation of this result is apparent. Micro-assays of prolactin by intracutaneous injections over crop-sacs must utilize a constant volume of fluid to be of much quantitative value.

Item Type: Paper
Subjects: organism description > animal > bird
CSHL Authors:
Communities: Station for Experimental Evolution at Cold Spring Harbor
Depositing User: Elizabeth Pessala
Date: 1940
Date Deposited: 13 Feb 2018 19:34
Last Modified: 13 Feb 2018 19:34
URI: https://repository.cshl.edu/id/eprint/35995

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