On the protein nature of prolactin and of follicle-stimulating hormones

Bates, Robert Wesley, Riddle, Oscar, Lahr, Ernest L. (1934) On the protein nature of prolactin and of follicle-stimulating hormones. Proceedings of the Society for Experimental Biology and Medicine, 31 (8). pp. 1223-1224.

URL: http://journals.sagepub.com/doi/pdf/10.3181/003797...
DOI: 10.3181/00379727-31-7511C


Prolactin is a protein-like substance which at pH 8.0 is almost completely destroyed by trypsin in 2 hours at 37°C. In confirmation of previous work though using the bird testis instead of the rodent ovary to test potency, it is found that the follicle-stimulating hormone obtained from the anterior pituitaries of cattle is very rapidly destroyed by trypsin under the above-named conditions. The methods used in the separation and purification of prolactin suggest that this hormone is a protein, but since it has not yet been obtained in a pure state the possibility of its adsorption on inert protein is not thus excluded. It is therefore desirable to learn whether prolactin is affected by tryptic digestion.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > hormones
CSHL Authors:
Communities: The Carnegie Institution Department of Genetics
Depositing User: Elizabeth Pessala
Date: 1934
Date Deposited: 23 May 2017 21:05
Last Modified: 23 May 2017 21:05
URI: https://repository.cshl.edu/id/eprint/34743

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