De novo osteogenic sarcoma in patients older than forty - Benefit of multimodality therapy

Manoso, M. W., Healey, J. H., Boland, P. J., Athanasian, E. A., Maki, R. G., Huvos, A. G., Morris, C. D. (September 2005) De novo osteogenic sarcoma in patients older than forty - Benefit of multimodality therapy. Clinical Orthopaedics and Related Research, &NA; (438). pp. 110-115. ISSN 0009-921x

DOI: 10.1097/01.blo.0000179587.42350.4d


The treatment of primary osteogenic sarcoma is well established in younger patients; however, controversy surrounds the treatment of this disease in the older population. To confirm multimodality therapy results in longer survival than surgery alone, 58 patients older than 40 years with primary osteogenic sarcoma were assessed retrospectively for the benefits of multimodality treatment versus surgery alone. We then asked whether specific patient and tumor characteristics and treatment modalities affected the rates of survival. Finally, we questioned whether pulmonary metastatectomy increased survival. The 5-year and 10-year overall survival for the group was 58% and 44%, respectively. Multimodality therapy increased survival compared with surgery alone in patients with high-grade disease. On multivariate analysis, considerable prognostic factors for improved overall survival for the entire group were age 3 younger than 60 years, volume less than 100 cm, normal alkaline phosphatase, localized disease, negative surgical margins, and absence of recurrence. Pulmonary metastatectomy improved survival in selected patients.

Item Type: Paper
Uncontrolled Keywords: neoadjuvant chemotherapy primary osteosarcoma metastases experience prognosis extremity resection tumor
Subjects: diseases & disorders > cancer > cancer types > sarcoma
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: September 2005
Date Deposited: 26 Oct 2016 20:37
Last Modified: 26 Oct 2016 20:37
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