Detection of herpes simplex RNA in human sensory ganglia

Galloway, D. A., Fenoglio, C., Shevchuk, M., McDougall, J. K. (May 1979) Detection of herpes simplex RNA in human sensory ganglia. Virology, 95 (1). pp. 265-8. ISSN 0042-6822 (Print)0042-6822 (Linking)

DOI: 10.1016/0042-6822(79)90429-X


Human paravertebral ganglia were examined for the presence of viral-specific RNA by in situ cytological hybridization using a nick-translated 3H-labeled herpes simplex virus-2 DNA probe. Ganglia from several locations (lumbar, thoracic, etc.) were obtained from seven patients at autopsy. In two cases HSV RNA was detected in all of the ganglia assayed. The autoradiographic grains were localized in the neurons (ganglions cells), and only a fraction of the neurons in any one ganglion were synthesizing viral-specific RNA. These results argue that the HSV genome can be active in the latent state.

Item Type: Paper
Uncontrolled Keywords: Ganglia/*analysis Genes, Viral Humans Neurons/*analysis Nucleic Acid Hybridization RNA, Viral/*analysis/biosynthesis *Simplexvirus/genetics/metabolism Transcription, Genetic
Subjects: organism description > virus > herpes simplex virus
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: May 1979
Date Deposited: 16 May 2016 20:47
Last Modified: 16 May 2016 20:47
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