Requirement for the large T and small T proteins of SV40 in the maintenance of the transformed state

Frisque, R. J., Rifkin, D. B., Topp, W. C. (1980) Requirement for the large T and small T proteins of SV40 in the maintenance of the transformed state. Cold Spring Harb Symp Quant Biol, 44 Pt . pp. 325-31. ISSN 0091-7451 (Print)0091-7451 (Linking)

DOI: 10.1101/SQB.1980.044.01.037


The virus-cell interaction that leads cells that are nonpermissive for viral growth to become transformed and ultimately tumorigenic is complex, involving multiple viral stimuli and an array of host responses. The portion of the SV40 genome required for the induction of transformation (Graham et al. 1975) encodes two proteins, large T (m.w. 96,000) and small T (m.w. 17,000) (Prives et al. 1977). In response to these two proteins, cells acquire a variety of properties not demonstrated by their uninfected counterparts. These transformed cells proliferate at higher temperatures (Ossowski and Sachs 1967), frequently grow to much higher population densities, grow in medium supplemented with only low levels of serum factors, and exhibit anchorage-independent growth (Risser and Pollack 1974).

Item Type: Paper
Uncontrolled Keywords: Animals *Antigens, Neoplasm *Antigens, Viral Antigens, Viral, Tumor Cell Division *Cell Transformation, Viral Cells, Cultured Cricetinae Culture Media Cytoskeleton/ultrastructure Methylcellulose Neoplasms, Experimental/microbiology Plasminogen Activators/biosynthesis Simian virus 40/*immunology Viral Proteins/*physiology Virus Replication
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell transformation
organism description > virus > SV40
organism description > virus
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 1980
Date Deposited: 08 Aug 2016 16:17
Last Modified: 08 Aug 2016 16:17
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