The association of alpha-actinin with the plasma membrane

Burridge, K., McCullough, L. (1980) The association of alpha-actinin with the plasma membrane. Journal of Supramolecular Structure, 13 (1). pp. 53-65. ISSN 0091-7419

DOI: 10.1002/jss.400130106


The role of alpha-actinin in the attachment of actin to plasma membranes has been investigated. Specific antibody staining of SDS gels has indicated that alpha-actinin is a major component in isolated plasma membranes prepared from three different cell types by two different procedures. Using specific extraction conditions, most of the alpha-actinin can be selectively extracted from the membranes with relatively little parallel release of actin. This selective dissociation of alpha-actinin from the plasma membrane leads us to conclude that alpha-actinin is present in these membrane preparations, because it is bound to actin, and that alpha-actinin does not form a direct link between actin and the membrane.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > actin
organs, tissues, organelles, cell types and functions > tissues types and functions > membranes
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 1980
Date Deposited: 10 Aug 2016 16:12
Last Modified: 10 Aug 2016 16:12
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