Inducing stable reversion to achieve cancer control

Powers, S., Pollack, R. E. (April 2016) Inducing stable reversion to achieve cancer control. Nature Reviews Cancer, 16 (4). pp. 266-270. ISSN 1474-175X

DOI: 10.1038/nrc.2016.12


How can we stop cancer progression? Current strategies depend on modelling progression as the balanced outcome of mutations in, and expression of, tumour suppressor genes and oncogenes. New treatments emerge from successful attempts to tip that balance, but secondary mutational escape from those treatments has become a major impediment because it leads to resistance. In this Opinion article, we argue for a return to an earlier stratagem: tumour cell reversion. Treatments based on selection and analysis of stable revertants could create more durable remissions by reducing the selective pressure that leads to rapid drug resistance.

Item Type: Paper
Subjects: diseases & disorders > cancer
CSHL Authors:
Communities: CSHL Cancer Center Program > Cancer Genetics
CSHL labs > Powers lab
CSHL Cancer Center Program > Cancer Genetics and Genomics Program
Depositing User: Matt Covey
Date: April 2016
Date Deposited: 26 Apr 2016 19:11
Last Modified: 05 Nov 2020 20:56
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