S100 beta as a neurotrophic factor

Marshak, D. R. (1990) S100 beta as a neurotrophic factor. Prog Brain Res, 86. pp. 169-81. ISSN 0079-6123 (Print)0079-6123 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/2087556
DOI: 10.1016/S0079-6123(08)63175-1


S100 beta is a multifunctional protein that is found in large amounts in astrocytes and a number of other tissues. In the developing nervous system, S100 beta is secreted from proliferating astrocytes during the time of neurite outgrowth from cortical neurons. The secreted form has neurotrophic activity on primary neurons and neuroblastoma cells. The neurotrophic activity is sensitive to reduction of disulfide bonds, and appears to be a disulfide dimer of S100 beta. The accumulation of S100 beta in mature glial cells is associated with microtubule network. The transfection and expression of cDNA for S100 beta in mammalian cells confers neurotrophic activity on extracts of these cells. Based on our observations of a neurotrophic activity for S100 beta, the occurrence of the gene for S100 beta on human chromosome 21 (Allore et al., 1988) and the elevated levels of S100 beta-containing cells in AD and DS brains (Griffin et al., 1989), we suggest that S100 beta plays a role in the abnormal development of the nervous system in DS and the degeneration of central neurons in AD. It is essential at the present stage to demonstrate the action of S100 beta in vivo, and to construct animal models, such as transgenic mice, that overexpress S100 beta. Such models will allow the dissection of the role of S100 beta in the developing and degenerating central nervous system.

Item Type: Paper
Uncontrolled Keywords: Amino Acid Sequence Animals Astrocytes/metabolism Axons/drug effects/ultrastructure Blood Proteins/genetics Calbindins Calcium-Binding Proteins/genetics Calgranulin A Cells, Cultured Chick Embryo Genes Growth Substances/pharmacology/*physiology Microtubules/ultrastructure Molecular Sequence Data Multigene Family Nerve Growth Factors Recombinant Fusion Proteins/genetics/pharmacology S100 Calcium Binding Protein G/genetics S100 Calcium Binding Protein beta Subunit S100 Proteins/pharmacology/*physiology Sequence Homology, Nucleic Acid
Subjects: neurobiology
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neurogenesis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > S100 beta protein
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 1990
Date Deposited: 21 Mar 2016 19:23
Last Modified: 21 Mar 2016 19:23
Related URLs:
URI: https://repository.cshl.edu/id/eprint/32332

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