Regulation of the G2-mitosis transition

Feilotter, H., Lingner, C., Rowley, R., Young, P. G. (October 1992) Regulation of the G2-mitosis transition. Biochem Cell Biol, 70 (10-11). pp. 954-71. ISSN 0829-8211 (Print)0829-8211 (Linking)



The cell cycle is regulated by pathways composed of a dependent series of steps, by timers, and by checkpoint controls which ensure the completion of one event before the initiation of another. This review focuses on the regulation of the initiation of mitosis, with particular emphasis on the regulation of p34cdc2 activity at this point in the cell cycle. The review draws on data from various organisms, but strongly emphasizes the genetic framework as seen in the fission yeast Schizosaccharomyces pombe and the biology and biochemistry of maturation promoting factor in frog oocytes. An attempt is made to include all known genes and proteins where a link can be made to the initiation event. The nutritional size control and its major known controlling elements, the wee1/mik1 protein kinases, and cdc25 protein tyrosine phosphatase are considered in detail along with their regulation. In addition, the checkpoint control pathways which mediate G2 delay in response to failure of DNA replication or DNA damage are examined.

Item Type: Paper
Uncontrolled Keywords: Animals CDC2 Protein Kinase/physiology Cyclins/physiology G2 Phase/*physiology Gene Expression Regulation, Fungal Maturation-Promoting Factor/physiology Mitosis/*physiology Saccharomyces cerevisiae/cytology Schizosaccharomyces/cytology Xenopus
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
organs, tissues, organelles, cell types and functions > organelles, types and functions > mitosis
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: October 1992
Date Deposited: 01 Oct 2015 18:36
Last Modified: 01 Oct 2015 18:36

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