Molecular biology primer for the pediatric pathologist

Demetrick, D. J. (March 1994) Molecular biology primer for the pediatric pathologist. Pediatr Pathol, 14 (2). pp. 339-67. ISSN 0277-0938 (Print)

DOI: 10.3109/15513819409024264


Recent advances in the knowledge of molecular events of cell growth and differentiation have provided considerable gains to the understanding of neoplasia. Along with this understanding, molecular biology has yielded many new techniques of great potential for diagnostic use. This review illustrates, in general terms, current models of gene regulation, intracellular signal transduction, and the regulation of cell division that are relevant to pediatric pathologists. These concepts are used to examine the molecular pathology of three pediatric tumors: retinoblastoma, Wilms' tumor, and neuroblastoma. In addition, molecular biology techniques potentially useful to pediatric pathologists are discussed, with examples of some possible applications of these techniques. Hopefully, this review portrays the relevance of molecular biology to pediatric pathologists and serves as a useful guide to the interpretation of the molecular pathology literature.

Item Type: Paper
Uncontrolled Keywords: Base Sequence Cell Cycle/physiology DNA, Recombinant Genes, Tumor Suppressor Genes, ras Humans Molecular Biology/ methods Molecular Sequence Data Neoplasms/genetics Oncogenes Pathology/ methods Pediatrics/ methods Proto-Oncogenes Second Messenger Systems Signal Transduction
Subjects: educational material
CSHL Authors:
Communities: CSHL labs > Beach lab
Depositing User: Matt Covey
Date: March 1994
Date Deposited: 21 Jul 2015 15:19
Last Modified: 21 Jul 2015 15:19
Related URLs:

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving