Signal Transduction: From the Atomic Age to the Post-Genomic Era

Thorner, J., Hunter, T., Cantley, L. C., Sever, R. (October 2014) Signal Transduction: From the Atomic Age to the Post-Genomic Era. Cold Spring Harbor Perspectives in Biology, 6 (12). a022913. ISSN 1943-0264

DOI: 10.1101/cshperspect.a022913


SUMMARY We have come a long way in the 55 years since Edmond Fischer and the late Edwin Krebs discovered that the activity of glycogen phosphorylase is regulated by reversible protein phosphorylation. Many of the fundamental molecular mechanisms that operate in biological signaling have since been characterized and the vast web of interconnected pathways that make up the cellular signaling network has been mapped in considerable detail. Nonetheless, it is important to consider how fast this field is still moving and the issues at the current boundaries of our understanding. One must also appreciate what experimental strategies have allowed us to attain our present level of knowledge. We summarize here some key issues (both conceptual and methodological), raise unresolved questions, discuss potential pitfalls, and highlight areas in which our understanding is still rudimentary. We hope these wide-ranging ruminations will be useful to investigators who carry studies of signal transduction forward during the rest of the 21st century.

Item Type: Paper
Subjects: educational material
historical documents
CSHL Authors:
Communities: CSHL Press
Depositing User: Matt Covey
Date: 30 October 2014
Date Deposited: 07 Nov 2014 17:06
Last Modified: 16 Jul 2021 20:25
PMCID: PMC4292159
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