TAFs: guilt by association?

Tansey, W. P., Herr, W. (March 1997) TAFs: guilt by association? Cell, 88 (6). pp. 729-32. ISSN 0092-8674

URL: http://www.ncbi.nlm.nih.gov/pubmed/9118213
DOI: 10.1016/S0092-8674(00)81916-9


Transcription is a key step in the regulation of gene expression. Activation of transcription requires that RNA polymerase both receive regulatory signals from promoter-specific activators and initiate transcription at the correct locations in the genome, the promoters. In prokaryotes, these tasks can be accomplished through the action of σ, a factor that associates with the core RNA polymerase, directs it to promoters, and serves as a target for regulatory factors. In eukaryotes, each of the three different RNA polymerases—I, II, and III—relies on distinct sets of general factors to perform these functions. One of the general factors utilized by RNA polymerase II that shares many of the properties of σ is TFIID, a protein complex consisting of the TATA box–binding protein TBP and TBP-associated factors called TAFs.

Item Type: Paper
Uncontrolled Keywords: Sigma Factor/genetics Transcription Factor TFIID Transcription Factors, TFII/ genetics Transcription, Genetic/ physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Herr lab
CSHL labs > Tansey lab
Depositing User: Kathleen Darby
Date: 21 March 1997
Date Deposited: 08 May 2014 14:47
Last Modified: 08 May 2014 14:47
Related URLs:
URI: https://repository.cshl.edu/id/eprint/29983

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