Combinatorial libraries: studies in molecular recognition

Nestler, H. P., Liu, R. (October 1998) Combinatorial libraries: studies in molecular recognition. Combinatorial Chemistry and High Throughput Screening, 1 (3). pp. 113-26. ISSN 1386-2073 (Print)



In recent years, combinatorial libraries have become a major tool for drug discovery and drug development. Along the way, one potential use of combinatorial chemistry libraries almost been neglected: the basic study of intermolecular interactions. Especially "one-bead-one-structure" libraries can be a powerful means for the discovery of ligands to synthetic receptors and vice versa. Encoded combinatorial libraries have been used to disclose ligands for well designed macrocyclic host molecules and to elucidate their specificities for peptide sequences. These studies led via receptors with more flexibility to simple host molecules without elaborate design that are accessible to combinatorial synthesis. These findings open a realm of possibilities and applications. An intriguing one is the development of chemical sensors for analytes that are otherwise hard or only unspecifically detected. Furthermore, such libraries and the techniques that were developed to handle them have been used to find new catalysts and enzyme mimics. In this review we put the emphasis on studies involving "one-bead-one-structure" libraries. We will review the techniques to generate them, to encode and analyze them, and to assay them. We will describe their past usage and the intriguing results of these studies and point out interesting new applications of such libraries for the study of non-covalent intermolecular interactions.

Item Type: Paper
Uncontrolled Keywords: Chemistry/ methods Drug Design Drug Evaluation, Preclinical Forecasting Ligands Metals/ metabolism Molecular Biology/methods Peptide Library Proteins/ chemistry/ metabolism Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > small molecules > cofactors > ligands
CSHL Authors:
Communities: CSHL labs > Nestler lab
Depositing User: Kathleen Darby
Date: October 1998
Date Deposited: 01 May 2014 14:22
Last Modified: 01 May 2014 14:22
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