Computer programs for the assembly of DNA sequences

Gingeras, T. R., Milazzo, J. P., Sciaky, D., Roberts, R. J. (September 1979) Computer programs for the assembly of DNA sequences. Nucleic Acids Research, 7 (2). pp. 529-45. ISSN 0305-1048 (Print)0305-1048

DOI: 10.1093/nar/7.2.529


A collection of user-interactive computer programs is described which aid in the assembly of DNA sequences. This is achieved by searching for the positions of overlapping common nucleotide sequences within the blocks of sequence obtained as primary data. Such overlapping segments are then melded into one continuous string of nucleotides. Strategies for determining the accuracy of the sequence being analyzed and reducing the error rate resulting from the manual manipulation of sequence data are discussed. Sequences mapping from 97.3 to 100% of the Ad2 virus genome were used to demonstrate the performance of these programs.

Item Type: Paper
Uncontrolled Keywords: Adenoviridae/analysis *Base Sequence Computers *Dna DNA, Viral Genes, Viral Methods
Subjects: bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
organism description > virus > adenovirus
bioinformatics > genomics and proteomics > computers > computer software
CSHL Authors:
Communities: CSHL labs > Gingeras lab
CSHL labs > Roberts lab
Depositing User: Matt Covey
Date: 25 September 1979
Date Deposited: 21 Mar 2014 19:22
Last Modified: 21 Mar 2014 19:22
PMCID: PMC328034
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