Prefabrication provides synapses on demand

Haas, K. (October 2000) Prefabrication provides synapses on demand. Trends in Neurosciences, 23 (10). p. 449. ISSN 0166-2236

DOI: 10.1016/S0166-2236(00)01678-7


The process of synaptogenesis between neurons is by no means uneventful. Axonal growth cones and dendritic filopodia rapidly extend and retract as they desperately attempt to find appropriate partners to form connections required for cell survival. During development in mammalian cortex, synaptogenesis proceeds at an amazing pace with the majority of connections formed during a brief 5-day window in the second postnatal week. The advent of powerful imaging techniques has allowed direct visualization of synaptogenesis in vivo and in vitro. Little is known, however, about how synaptogenesis is initiated, the molecular events involved and the time course of these processes.

Item Type: Paper
Uncontrolled Keywords: Animals Axonal Transport Cerebral Cortex/ cytology Dendrites/physiology/ultrastructure Growth Cones/physiology/ultrastructure Membrane Fusion Microscopy, Video Nerve Tissue Proteins/metabolism Presynaptic Terminals/physiology/ultrastructure Pseudopodia/physiology Receptors, Glutamate/metabolism Synapses/ physiology/ultrastructure
Subjects: organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic plasticity
organs, tissues, organelles, cell types and functions > tissues types and functions > synaptogenesis
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: Matt Covey
Date: October 2000
Date Deposited: 30 Jan 2014 15:47
Last Modified: 30 Jan 2014 15:47
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