The identification and tracking of Candida albicans isolates from oral lesions in HIV-seropositive individuals

Miyasaki, S. H., Hicks, J. B., Greenspan, D., Polacheck, I., MacPhail, L. A., White, T. C., Agabian, N., Greenspan, J. S. (1992) The identification and tracking of Candida albicans isolates from oral lesions in HIV-seropositive individuals. Journal of Acquired Immune Deficiency Syndromes, 5 (10). pp. 1039-1046. ISSN 08949255 (ISSN)



Restriction fragment polymorphism analysis was used to investigate the identity and genotypic relatedness of Candida albicans strains isolated from human immunodeficiency virus (HIV)-infected patients with or without oral candidiasis and from some of their sexual partners. Use of the species- specific DNA probe Ca3 revealed that most subjects carried a single distinct C. albicans strain throughout the course of the study, during both symptomatic and asymptomatic periods. Sexual partners were more likely to carry the same or similar C. albicans isolates than unrelated subjects, raising the possibility of transmission via intimate contact. One patient appeared to acquire his partner's isolate, which then became predominant in both partners in subsequent isolations. These findings indicate that recurrent oral candidiasis is usually caused by a single persistent strain unique to each patient, but that in some cases transmission via intimate contact may occur between sexual partners.

Item Type: Paper
Uncontrolled Keywords: adult article candida albicans clinical article female human human immunodeficiency virus infection human tissue male mouth lesion restriction fragment length polymorphism thrush AIDS-Related Opportunistic Infections Blotting, Southern Candidiasis DNA, Fungal Genome, Fungal HIV Seropositivity Homosexuality Ketoconazole Mouth Nystatin Polymorphism (Genetics) Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.
Subjects: diseases & disorders
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Hicks lab
Depositing User: Matt Covey
Date: 1992
Date Deposited: 09 Aug 2013 20:55
Last Modified: 12 Aug 2013 14:55
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