How the ubiquitin-proteasome system controls transcription

Muratani, Masafumi, Tansey, William P. (March 2003) How the ubiquitin-proteasome system controls transcription. Nature Reviews Molecular Cell Biology, 4 (3). pp. 192-201. ISSN 1471-0072

Abstract

Gene transcription and ubiquitin-mediated proteolysis are two processes that have seemingly nothing in common: transcription is the first step in the life of any protein and proteolysis the last. Despite the disparate nature of these processes, a growing body of evidence indicates that ubiquitin and the proteasome are intimately involved in gene control. Here, we discuss the deep mechanistic connections between transcription and the ubiquitin-proteasome system, and highlight how the intersection of these processes tightly controls expression of the genetic information.

Item Type:	Paper
Uncontrolled Keywords:	RNA-POLYMERASE-II TATA-BINDING PROTEIN SACCHAROMYCES-CEREVISIAE 26S PROTEASOME HISTONE H2B MEDIATED DEGRADATION ACTIVATION DOMAIN LARGE SUBUNIT DNA-DAMAGE DEPENDENT DEGRADATION
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > DNA polymerase bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > proteolysis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > ubiquitin ligase
CSHL Authors:	Muratani, Masafumi Tansey, William P.
Communities:	CSHL labs > Tansey lab School of Biological Sciences > Publications
Depositing User:	Matt Covey
Date:	March 2003
Date Deposited:	01 Jul 2013 16:45
Last Modified:	19 Sep 2014 14:43
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27894

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