The fibroblastic coconspirator in cancer progression

Egeblad, M., Littlepage, L. E., Werb, Z. (2005) The fibroblastic coconspirator in cancer progression. Cold Spring Harbor Symposia on Quantitative Biology, 70. pp. 383-388. ISSN 00917451 (ISSN)



A remarkable change has occurred in the thinking about epithelial-derived cancer in recent years: From almost entirely focusing on oncogenes and tumor suppressor genes has come the realization that the tumor microenvironment is a coconspirator in the carcinogenic process. Many types of stromal cells, including fibroblasts, adipocytes, macrophages, mast cells, and cells of the vascular system, are crucial contributors to epithelial carcinogenesis. Here, we focus on the fibroblast's role in cancer progression and the molecules involved in the communications between the fibroblasts and the cancer cells, including fibroblast secreted protein 1 (FSP-1 or S100A4), transforming growth factor β (TGF-β), the chemokine CXCL-12 (stromal derived factor 1 α, SDF-1β), type I collagen, and matrix metalloproteinase 13 (MMP-13). © 2005 Cold Spring Harbor Laboratory Press.

Item Type: Paper
Uncontrolled Keywords: calvasculin collagen type 1 collagenase 3 stromal cell derived factor 1 transforming growth factor beta adipocyte cancer cell cancer growth carcinogenesis cardiovascular system cell type conference paper epithelium cell fibroblast human macrophage mast cell microenvironment nonhuman oncogene priority journal stroma cell Animals Calcium-Binding Proteins Chemokines, CXC Collagen Type I Fibroblasts Humans Matrix Metalloproteinases Models, Biological Neoplasms
Subjects: diseases & disorders > cancer
diseases & disorders
CSHL Authors:
Communities: CSHL labs > Egeblad lab
Depositing User: Matt Covey
Date: 2005
Date Deposited: 14 Mar 2013 19:56
Last Modified: 14 Mar 2013 19:56
PMCID: PMC2580828
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