Coevolution of cancer and stromal cellular responses

Littlepage, L. E., Egeblad, M., Werb, Z. (2005) Coevolution of cancer and stromal cellular responses. Cancer Cell, 7 (6). pp. 499-500. ISSN 15356108 (ISSN)

DOI: 10.1016/j.ccr.2005.05.019


It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1α (CXCL12). SDF-1α stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells. Copyright © 2005 Elsevier Inc.

Item Type: Paper
Uncontrolled Keywords: stromal cell derived factor 1alpha transforming growth factor beta adipocyte breast carcinoma cancer inhibition carcinogenesis carcinoma cell cell hyperplasia cell proliferation cell stimulation cell type cellular immunity cytokine release endothelium cell epithelium cell fibroblast gene expression gene mutation human macrophage mast cell molecular evolution nonhuman priority journal short survey stem cell stroma cell Animals Calcium-Binding Proteins Cell Movement Chemokines, CXC Endothelial Cells Fibroblasts Humans Leukocytes Matrix Metalloproteinase 9 Mesenchymal Stem Cells Models, Biological Neoplasms Neovascularization, Pathologic Stromal Cells
Subjects: diseases & disorders > cancer
diseases & disorders
CSHL Authors:
Communities: CSHL labs > Egeblad lab
Depositing User: Matt Covey
Date: 2005
Date Deposited: 14 Mar 2013 19:58
Last Modified: 14 Mar 2013 19:58
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