Genetic similarities between organogenesis and tumorigenesis of the lung

Powers, S., Mu, D. (January 2008) Genetic similarities between organogenesis and tumorigenesis of the lung. Cell Cycle, 7 (2). 200 - 204 .

DOI: 10.4161/cc.7.2.5284


In hematological malignancies, there are numerous examples of lymphocyte developmental genes playing a role in cancer formation. In this article, we discuss how processes of fetal organogenesis are also operant in lung tumorigenesis. We first review four pathways important in lung cancer (MYC, Hedgehog, Rb and Wnt) and describe the experimental evidence linking them to lung development. Then, we review genome-wide analysis approaches of both RNA (gene expression profiling) and DNA (copy number alterations) and how they have uncovered links between lung cancer and fetal lung development. Finally, the recent discovery of three closely linked developmental transcription factors, which are co-amplified as cooperating lung oncogenes, is discussed. We suggest that inhibition of the fetal developmental pathways selectively reactivated in cancer cells is a research area of interest for novel anti-cancer therapies in light of the presumed low toxicity of such therapies to the nearby normal adult cells.

Item Type: Paper
Uncontrolled Keywords: lung development lung cancer lineage-survival oncogene gene amplification TTF1 NKX2-8 PAX9
Subjects: diseases & disorders > cancer
diseases & disorders
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
diseases & disorders > cancer > cancer types > lung cancer
diseases & disorders > cancer > cancer types
CSHL Authors:
Communities: CSHL labs > Powers lab
Depositing User: Matt Covey
Date: 15 January 2008
Date Deposited: 26 Feb 2013 20:59
Last Modified: 26 Feb 2013 20:59
Related URLs:

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving