Poster: HORIBALFRE: Higher order residue interactions based ALgorithm for fold REcognition

Sundaramurthy, P., Sreenivasan, R., Shameer, K., Gakkhar, S., Sowdhamini, R. (February 2011) Poster: HORIBALFRE: Higher order residue interactions based ALgorithm for fold REcognition. 1st International Conference onComputational Advances in Bio and Medical Sciences (ICCABS). p. 262.

DOI: 10.1109/ICCABS.2011.5729916


In an attempt to enhance the potential based fold - recognition methods of remote homologs, we propose a new approach "Higher Order Residue Interaction Based ALgorithm for Fold REcognition (HORIBALFRE)", where we incorporated the potential contributions not just from one-body and two-body terms, but from three body (triplet interactions) and four-body (quadruple interaction) interactions, to implement a new fold recognition method. Core of HORIBALFRE includes the potentials generated from a structure library derived from CAMPASS database of structure based sequence alignment. Currently, the algorithm is applied to the Fischer's dataset. Our preliminary result indicates that inclusion of higher order residue interaction (quadruple) potentials increases the prediction performance. © 2011 IEEE.

Item Type: Paper
Additional Information: Meeting Abstract
Subjects: bioinformatics
bioinformatics > computational biology
Publication Type > Meeting Abstract
CSHL Authors:
Communities: CSHL labs > McCombie lab
Depositing User: Matt Covey
Date: February 2011
Date Deposited: 05 Feb 2013 16:44
Last Modified: 28 Feb 2018 16:39

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