Following the genes: A framework for animal modeling of psychiatric disorders

Mitchell, K. J., Huang, Z. J., Moghaddam, B., Sawa, A. (November 2011) Following the genes: A framework for animal modeling of psychiatric disorders. BMC Biology, 9 (11). Article 76. ISSN 17417007

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DOI: 10.1186/1741-7007-9-76


The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models with direct etiological validity. Defining the underlying pathogenic mechanisms will require an experimental and theoretical framework to make the links from mutation to altered behavior in an animal or psychopathology in a human. Here, we discuss key elements of such a framework, including cell type-based phenotyping, developmental trajectories, linking circuit properties at micro and macro scales and definition of neurobiological phenotypes that are directly translatable to humans. © 2011 Mitchell et al; licensee BioMed Central Ltd.

Item Type: Paper
Additional Information: Article Number 76
Uncontrolled Keywords: Allelic heterogeneity Autism Cre Eeg Functional connectivity Interneurons Microcircuits Rare mutations Schizophrenia Synaptic
Subjects: diseases & disorders > nervous system diseases and disorders
organism description > model organism
organism description > animal > mammal > rodent > mouse
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date: 11 November 2011
Date Deposited: 10 Apr 2012 16:18
Last Modified: 10 May 2013 15:02
PMCID: PMC3214139

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