Genome-wide transcription and the implications for genomic organization

Kapranov, P., Willingham, A. T., Gingeras, T. R. (2007) Genome-wide transcription and the implications for genomic organization. Nature Reviews Genetics, 8 (6). pp. 413-423. ISSN 14710056 (ISSN)

DOI: 10.1038/nrg2083


Recent evidence of genome-wide transcription in several species indicates that the amount of transcription that occurs cannot be entirely accounted for by current sets of genome-wide annotations. Evidence indicates that most of both strands of the human genome might be transcribed, implying extensive overlap of transcriptional units and regulatory elements. These observations suggest that genomic architecture is not colinear, but is instead interleaved and modular, and that the same genomic sequences are multifunctional: that is, used for multiple independently regulated transcripts and as regulatory regions. What are the implications and consequences of such an interleaved genomic architecture in terms of increased information content, transcriptional complexity, evolution and disease states? © 2007 Nature Publishing Group.

Item Type: Paper
Uncontrolled Keywords: RNA biotechnology exon gene expression gene mapping gene sequence genetic transcription genetic variability genome analysis human human genetics molecular evolution nonhuman priority journal promoter region regulatory sequence review RNA transcription structural genomics transcription initiation Animals Evolution, Molecular Genes, Regulator Genetic Techniques Genome Genome Human Humans Models Genetic Promoter Regions (Genetics) RNA Antisense Signal Transduction Transcription Genetic
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
CSHL Authors:
Communities: CSHL labs > Gingeras lab
Depositing User: CSHL Librarian
Date: 2007
Date Deposited: 08 Mar 2012 16:18
Last Modified: 12 Jul 2013 20:01
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