Nitric Oxide Coordinates Cell Proliferation and Cell Movements During Early Development of Xenopus

Peunova, N., Scheinker, V., Ravi, K., Enikolopov, G. N. (December 2007) Nitric Oxide Coordinates Cell Proliferation and Cell Movements During Early Development of Xenopus. Cell Cycle, 6 (24). pp. 3132-44.

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DOI: 10.4161/cc.6.24.5146


The establishment of a vertebrate body plan during embryogenesis is achieved through precise coordination of cell proliferation and morphogenetic cell movements. Here we show that nitric oxide (NO) suppresses cell division and facilitates cell movements during early development of Xenopus, such that inhibition of NO synthase (NOS) increases proliferation in the neuroectoderm and suppresses convergent extension in the axial mesoderm and neuroectoderm. NO controls cell division and cell movement through two separate signaling pathways. Both rely on RhoA-ROCK signaling but can be distinguished by the involvement of either guanylate cyclase or the planar cell polarity regulator Dishevelled. Through the cGMP-dependent pathway, NO suppresses cell division by negatively regulating RhoA and controlling the nuclear distribution of ROCK and p21WAF1. Through the cGMP-independent pathway, NO facilitates cell movement by regulating the intracellular distribution and level of Dishevelled and the activity of RhoA, thereby controlling the activity of ROCK and regulating actin cytoskeleton remodeling and cell polarization. Concurrent control by NO helps ensure that the crucial processes of cell proliferation and morphogenetic movements are coordinated during early development.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > embryogenesis
bioinformatics > genomics and proteomics > small molecules > nitric oxide
organism description > animal > Frog > xenopus
CSHL Authors:
Communities: CSHL labs > Enikopolov lab
Depositing User: CSHL Librarian
Date: 6 December 2007
Date Deposited: 07 Nov 2011 21:08
Last Modified: 28 Feb 2017 21:44
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