Bayesian shadows of molecular mechanisms cast in the light of evolution

Neuwald, A. F. (July 2006) Bayesian shadows of molecular mechanisms cast in the light of evolution. Trends Biochem Sci, 31 (7). pp. 374-82. ISSN 0968-0004 (Print)

DOI: 10.1016/j.tibs.2006.05.002


A great many carefully designed experiments will be required to fully understand biological mechanisms in atomic detail. A complementary approach is to use powerful statistical procedures to rapidly test numerous scientific hypotheses using vast numbers of protein sequences--the cell's own blueprints for specifying biological mechanisms. Bayesian inference of the evolutionary constraints imposed on functionally divergent proteins can reveal key components of the molecular machinery and thereby suggest likely mechanisms to test experimentally. This approach is demonstrated by considering how DNA polymerase clamp-loader AAA+ ATPases couple DNA recognition to ATP hydrolysis and clamp loading.

Item Type: Paper
Uncontrolled Keywords: Adenosine Triphosphatases metabolism Adenosine Triphosphate metabolism Amino Acid Sequence Bayes Theorem DNA Polymerase III physiology Evolution Molecular Models Molecular Molecular Sequence Data Replication Protein C physiology Sequence Alignment
Subjects: bioinformatics > genomics and proteomics > annotation > sequence annotation
bioinformatics > genomics and proteomics > analysis and processing > Sequence Data Processing
bioinformatics > genomics and proteomics > Mapping and Rendering > Sequence Rendering
bioinformatics > computational biology
CSHL Authors:
Communities: CSHL labs > Neuwald lab
Depositing User: CSHL Librarian
Date: July 2006
Date Deposited: 09 Dec 2011 17:27
Last Modified: 27 Apr 2018 14:27
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