At the heart of the chromosome: SMC proteins in action

Hirano, T. (May 2006) At the heart of the chromosome: SMC proteins in action. Nat Rev Mol Cell Biol, 7 (5). pp. 311-22. ISSN 1471-0072 (Print)

DOI: 10.1038/nrm1909


Structural maintenance of chromosomes (SMC) proteins are ubiquitous in organisms from bacteria to humans, and function as core components of the condensin and cohesin complexes in eukaryotes. SMC proteins adopt a V-shaped structure with two long arms, each of which has an ATP-binding head domain at the distal end. It is important to understand how these uniquely designed protein machines interact with DNA strands and how such interactions are modulated by the ATP-binding and -hydrolysis cycle. An emerging idea is that SMC proteins use a diverse array of intramolecular and intermolecular protein-protein interactions to actively fold, tether and manipulate DNA strands.

Item Type: Paper
Uncontrolled Keywords: Adenosine Triphosphatases metabolism Animals Cell Cycle Proteins metabolism Chromatids metabolism Chromosomal Proteins Non-Histone chemistry metabolism Chromosomes genetics metabolism DNA-Binding Proteins metabolism Humans Multiprotein Complexes metabolism Nuclear Proteins metabolism Nucleic Acid Heteroduplexes chemistry
Subjects: bioinformatics > genomics and proteomics > design > protein design
CSHL Authors:
Communities: CSHL labs > Hirano lab
Depositing User: CSHL Librarian
Date: May 2006
Date Deposited: 13 Dec 2011 19:01
Last Modified: 17 Apr 2018 14:24
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