SynBrowse: a synteny browser for comparative sequence analysis

Pan, X. K., Stein, L. D., Brendel, V. (September 2005) SynBrowse: a synteny browser for comparative sequence analysis. Bioinformatics, 21 (17). pp. 3461-3468. ISSN 1367-4803



Motivation: The recent efforts of various sequence projects to sequence deeply into various phylogenies provide great resources for comparative sequence analysis. A generic and portable tool is essential for scientists to visualize and analyze sequence comparisons. Results: We have developed SynBrowse, a synteny browser for visualizing and analyzing genome alignments both within and between species. It is intended to help scientists study macrosynteny, microsynteny and homologous genes between sequences. It can also aid with the identification of uncharacterized genes, putative regulatory elements and novel structural features of a species. SynBrowse is a GBrowse (the Generic Genome Browser) family software tool that runs on top of the open source BioPerl modules. It consists of two components: a web-based front end and a set of relational database back ends. Each database stores pre-computed alignments from a focus sequence to reference sequences in addition to the genome annotations of the focus sequence. The user interface lets end users select a key comparative alignment type and search for syntenic blocks between two sequences and zoom in to view the relationships among the corresponding genome annotations in detail. SynBrowse is portable with simple installation, flexible configuration, convenient data input and easy integration with other components of a model organism system.

Item Type: Paper
Additional Information: ISI Document Delivery No.: 958UA Times Cited: 3 Cited Reference Count: 30
Uncontrolled Keywords: Genome Sequence EVOLUTION GENE Database Alignments DNA macrosynteny
Subjects: bioinformatics > genomics and proteomics > databases > database construction
bioinformatics > genomics and proteomics > databases > database optimization
bioinformatics > genomics and proteomics > databases > database search and retrieval
bioinformatics > genomics and proteomics > annotation > phylogenetic tree annotation
bioinformatics > genomics and proteomics > databases > databases
CSHL Authors:
Communities: CSHL labs > Stein lab
Depositing User: CSHL Librarian
Date: September 2005
Date Deposited: 09 Jan 2012 14:23
Last Modified: 09 Jan 2012 14:23

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