Hirano, T. (April 2005) Condensins: organizing and segregating the genome. Curr Biol, 15 (7). R265-75. ISSN 0960-9822 (Print)
Abstract
Condensins are multi-subunit protein complexes that play a central role in mitotic chromosome assembly and segregation. The complexes contain 'structural maintenance of chromosomes' (SMC) ATPase subunits, and induce DNA supercoiling and looping in an ATP-hydrolysis-dependent manner in vitro. Vertebrate cells have two different condensin complexes, condensins I and II, each containing a unique set of regulatory subunits. Condensin II participates in an early stage of chromosome condensation within the prophase nucleus. Condensin I gains access to chromosomes only after the nuclear envelope breaks down, and collaborates with condensin II to assemble metaphase chromosomes with fully resolved sister chromatids. The complexes also play critical roles in meiotic chromosome segregation and in interphase processes such as gene repression and checkpoint responses. In bacterial cells, ancestral forms of condensins control chromosome dynamics. Dissecting the diverse functions of condensins is likely to be central to our understanding of genome organization, stability and evolution.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adenosine Triphosphatases metabolism physiology Cell Cycle Proteins metabolism physiology Chromosome Segregation physiology DNA-Binding Proteins genetics metabolism physiology Evolution, Molecular Gene Expression Regulation Genome Kinetochores physiology Models Biological Multiprotein Complexes Phylogeny |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > condensin complex |
| CSHL Authors: | |
| Communities: | CSHL labs > Hirano lab |
| Depositing User: | CSHL Librarian |
| Date: | 12 April 2005 |
| Date Deposited: | 12 Jan 2012 19:42 |
| Last Modified: | 07 May 2018 15:20 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22596 |
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