Synaptogenesis: a balancing act between excitation and inhibition

Cline, H. T. (March 2005) Synaptogenesis: a balancing act between excitation and inhibition. Curr Biol, 15 (6). R203-5. ISSN 0960-9822 (Print)

DOI: 10.1016/j.cub.2005.03.010


Recent studies have implicated a number of membrane-associated proteins, including the signaling pair neuroligin and beta-neurexin, in synapse formation, suggesting that they govern the ratio of inhibitory and excitatory synapses on CNS neurons. These findings, together with data indicating that the genes encoding neuroligin and PSD95 are altered in autism patients, suggest that a molecular understanding of complex neurological diseases is within reach.

Item Type: Paper
Uncontrolled Keywords: Autistic Disorder genetics Central Nervous System physiology Gene Expression Regulation physiology Humans Intracellular Signaling Peptides and Proteins Membrane Proteins/genetics metabolism Models Biological Mutation genetics Nerve Tissue Proteins genetics metabolism Neurons metabolism Signal Transduction Synapses metabolism physiology
Subjects: diseases & disorders > mental disorders > personality disorders > autism
organs, tissues, organelles, cell types and functions > tissues types and functions > membranes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: CSHL Librarian
Date: 29 March 2005
Date Deposited: 13 Jan 2012 20:02
Last Modified: 03 May 2018 14:32
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