Essential function of nitric oxide synthase in Drosophila

Regulski, M., Stasiv, Y., Tully, T., Enikolopov, G. (October 2004) Essential function of nitric oxide synthase in Drosophila. Current Biology, 14 (20). R881-R882. ISSN 0960-9822

DOI: 10.1016/j.cub.2004.09.068


Nitric oxide (NO), produced by NO synthases (NOS), is a short-lived intra- and transcellular messenger that regulates many physiological functions in vertebrates and invertebrates (e.g., blood pressure, muscle contraction, innate immunity, cell division and differentiation, response to hypoxia, and memory formation [1]). Given its numerous functions, it might be expected that a lack of NOS activity would be lethal for the developing organism. However, such an indispensable role for NO in development has not yet been demonstrated. A genetic analysis of NO function in vertebrates is complicated by the presence of three NOS genes. Mice with a homozygous ablation of any single NOS gene are viable, animals with two NOS genes knocked out show drastically reduced viability and triple knockout animals have not yet been generated 2., 3., 4., 5. and 6..

Item Type: Paper
Uncontrolled Keywords: MICE LACKING mice lacking GENE gene DNOS
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > nitric oxide synthase
CSHL Authors:
Communities: CSHL labs > Enikopolov lab
Depositing User: CSHL Librarian
Date: October 2004
Date Deposited: 26 Jan 2012 21:12
Last Modified: 01 Mar 2017 16:52
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