Evolution of duplicated growth hormone genes in autotetraploid salmonid fishes

McKay, S. J., Trautner, J., Smith, M. J., Koop, B. F., Devlin, R. H. (August 2004) Evolution of duplicated growth hormone genes in autotetraploid salmonid fishes. Genome, 47 (4). pp. 714-23. ISSN 0831-2796 (Print)

URL: http://www.scopus.com/record/display.url?eid=2-s2....
DOI: 10.1139/g04-018


A defining character of the piscine family Salmonidae is autotetraploidy resulting from a genome-doubling event some 25-100 million years ago. Initially, duplicated genes may have undergone concerted evolution and tetrasomic inheritance. Homeologous chromosomes eventually diverged and the resulting reduction in recombination and gene conversion between paralogous genes allowed the re-establishment of disomic inheritance. Among extant salmonine fishes (e.g. salmon, trout, char) the growth hormone (GH) gene is generally represented by two functional paralogs, GH1 and GH2. Sequence analyses of salmonid GH genes from species of subfamilies Coregoninae (whitefish, ciscos) and Salmoninae were used to examine the evolutionary history of the duplicated GH genes. Two divergent GH gene paralogs were also identified in Coregoninae, but they were not assignable to the GH1 and GH2 categories. The average sequence divergence between the coregonine GH genes was more than twofold lower than the corresponding divergence between the salmonine GH1 and GH2. Phylogenetic analysis of the coregonine GH paralogs did not resolve their relationship to the salmonine paralogs. These findings suggest that disomic inheritance of two GH genes was established by different mechanisms in these two subfamilies.

Item Type: Paper
Uncontrolled Keywords: Animals Base Sequence DNA genetics Evolution Molecular Fish Proteins genetics Gene Duplication Growth Hormone genetics Introns Microsatellite Repeats Molecular Sequence Data Phylogeny Polymorphism Genetic Polyploidy Salmonidae classification genetics Sequence Homology, Nucleic Acid Species Specificity
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
CSHL Authors:
Depositing User: CSHL Librarian
Date: August 2004
Date Deposited: 31 Jan 2012 15:18
Last Modified: 31 Jan 2012 15:18
URI: https://repository.cshl.edu/id/eprint/22437

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