Twisting DNA: single molecule studies

Charvin, G., Allemand, J. F., Strick, T. R., Bensimon, D., Croquette, V. (September 2004) Twisting DNA: single molecule studies. Contemporary Physics, 45 (5). pp. 383-403. ISSN 0010-7514



Over the past 10 years a number of new techniques have emerged that allow the manipulation of single DNA molecules and other biopolymers (RNA, proteins, etc.). These experiments have permitted the measurement of the DNA stretching and twisting elasticity and have consequently revealed the essential role played by the DNA mechanical properties in its interactions with proteins. We shall first describe the different methods used to stretch and twist single DNA molecules. We will then focus on its behaviour under torsion, especially by discussing the different methods used to estimate its torsional modulus.

Item Type: Paper
Uncontrolled Keywords: SUPERCOILED DNA supercoiled DNA TORSIONAL RIGIDITY Torsional Rigidity STRUCTURAL TRANSITIONS structural transitions ENTROPIC entropic ELASTICITY elasticity FORCE SPECTROSCOPY force spectroscopy FLUCTUATIONS fluctuations CHAIN chain DEPENDENCE dependence EXTENSION extension TWEEZERS tweezers
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > sDNA
CSHL Authors:
Depositing User: CSHL Librarian
Date: September 2004
Date Deposited: 14 Feb 2012 19:55
Last Modified: 14 Feb 2012 19:55

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