Additional materials of the author at
CSHL Institutional Repository

Wroten, Mathew, Yoon, Seungtai, Andrews, Peter, Yamrom, Boris, Ronemus, Michael, Buja, Andreas, Krieger, Abba M, Levy, Dan, Ye, Kenny, Wigler, Michael , Iossifov, Ivan (2023) Sharing parental genomes by siblings concordant or discordant for autism. Cell Genomics, 3(6) pp. 100319.

Lammertse, E, Li, S, Kendall, J, Kim, C, Morris, P, Ranade, N, Levy, D, Wigler, M , Brouzes, E (2023) Magnetically Functionalized Hydrogels for High-Throughput Genomic Applications. Advanced Materials Technologies,

Wang, Zihua, Moffitt, Andrea B, Andrews, Peter, Wigler, Michael , Levy, Dan (2022) Accurate measurement of microsatellite length by disrupting its tandem repeat structure. Nucleic Acids Research, pp. gkac723.

Li, Siran, Park, Sarah, Ye, Catherine, Danyko, Cassidy, Wroten, Matthew, Andrews, Peter, Wigler, Michael , Levy, Dan (2022) Targeted de novo phasing and long-range assembly by template mutagenesis. Nucleic Acids Research,

Yoon, Seungtai, Munoz, Adriana, Yamrom, Boris, Lee, Yoon-Ha, Andrews, Peter, Marks, Steven, Wang, Zihua, Reeves, Catherine, Winterkorn, Lara, Krieger, Abba M, Buja, Andreas, Pradhan, Kith, Ronemus, Michael, Baldwin, Kristin K, Levy, Dan, Wigler, Michael , Iossifov, Ivan (2021) Rates of contributory de novo mutation in high and low-risk autism families.. Communications Biology, 4(1) pp. 1026.

Chorbadjiev, L., Kendall, J., Alexander, J., Zhygulin, V., Song, J., Wigler, M. , Krasnitz, A. (2020) Integrated Computational Pipeline for Single-Cell Genomic Profiling. JCO Clinical Cancer Informatics, 4 pp. 464-471.

Baslan, T., Kendall, J., Volyanskyy, K., McNamara, K., Cox, H., D'Italia, S., Ambrosio, F., Riggs, M., Rodgers, L., Leotta, A., Song, J., Mao, Y., Wu, J., Shah, R., Gularte-Merida, R., Chadalavada, K., Nanjangud, G., Varadan, V., Gordon, A., Curtis, C., Krasnitz, A., Dimitrova, N., Harris, L., Wigler, M. , Hicks, J. (2020) Novel Insights Into Breast Cancer Copy Number Genetic Heterogeneity Revealed by Single-Cell Genome Sequencing. Elife, 9 pp. e51480.

Vasudevan, A., Baruah, P.S., Smith, J.C., Wang, Z., Sayles, N. M., Andrews, P., Kendall, J., Leu, J., Chunduri, N.K., Levy, D., Wigler, M., Storchova, Z. , Sheltzer, J. M. (2020) Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer. Developmental Cell, 52(4) pp. 413-428.

Moffitt, A. B., Spector, M. S., Andrews, P., Kendall, J., Alexander, J., Stepansky, A., Ma, B., Kolitz, J., Chiorazzi, N., Allen, S.L., Krasnitz, A., Wigler, M., Levy, D. , Wang, Z. (2020) Multiplex Accurate Sensitive Quantitation (MASQ) With Application to Minimal Residual Disease in Acute Myeloid Leukemia. Nucleic Acids Research, 48(7) pp. e40.

Li, S., Kendall, J., Park, S., Wang, Z., Alexander, J., Moffitt, A., Ranade, N., Danyko, C., Gegenhuber, B., Fischer, S., Robinson, B. D., Lepor, H., Tollkuhn, J., Gillis, J., Brouzes, E., Krasnitz, A., Levy, D. , Wigler, M. (2019) Copolymerization of single-cell nucleic acids into balls of acrylamide gel. Genome Res, 30(1) pp. 49-61.

Buja, A., Volfovsky, N., Krieger, A. M., Lord, C., Lash, A. E., Wigler, M. , Iossifov, I. (2018) Damaging de novo mutations diminish motor skills in children on the autism spectrum. Proc Natl Acad Sci U S A, 115(8) pp. E1859-E1866.

Kumar, V., Rosenbaum, J., Wang, Z., Forcier, T., Ronemus, M., Wigler, M. , Levy, D. (2018) Partial bisulfite conversion for unique template sequencing. Nucleic Acids Res, 46(2) pp. e10.

Alexander, J., Kendall, J., McIndoo, J., Rodgers, L., Aboukhalil, R., Levy, D., Stepansky, A., Sun, G., Chobadjiev, L., Riggs, M., Cox, H., Hakker, I., Nowak, D. G., Laze, J., Llukani, E., Srivastava, A., Gruschow, S., Yadav, S. S., Robinson, B. D., Atwal, G., Trotman, L. C., Lepor, H., Hicks, J. B., Wigler, M. , Krasnitz, A. (2018) Utility of single cell genomics in diagnostic evaluation of prostate cancer. Cancer Res, 78(2) pp. 348-358.

Ye, K., Iossifov, I., Levy, D., Yamrom, B., Buja, A., Krieger, A. M. , Wigler, M. (2017) Measuring shared variants in cohorts of discordant siblings with applications to autism. Proc Natl Acad Sci U S A, 114(27) pp. 7073-7076.

Krasnitz, Alexander, Kendall, Jude, Alexander, Joan, Levy, Dan , Wigler, Michael (2017) Early Detection of Cancer in Blood Using Single-Cell Analysis: A Proposal. Trends in Molecular Medicine, 23(7) pp. 594-603.

Kumar, Vijay, Rosenbaum, Julie, Wang, Zihua, Forcier, Talitha, Ronemus, Michael, Wigler, Michael , Levy, Dan (2017) Mutational sequencing for accurate count and long-range assembly. bioRxiv,

Munoz, Adriana, Yamrom, Boris, Lee, Yoon-ha, Andrews, Peter, Marks, Steven, Lin, Kuan-Ting, Wang, Zihua, Krainer, Adrian R., Darnell, Robert B., Wigler, Michael , Iossifov, Ivan (2017) De novo indels within introns contribute to ASD incidence. bioRxiv, pp. 137471.

Fang, H., Bergmann, E. A., Arora, K., Vacic, V., Zody, M. C., Iossifov, I., O'Rawe, J. A., Wu, Y., Jimenez Barron, L. T., Rosenbaum, J., Ronemus, M., Lee, Y. H., Wang, Z., Dikoglu, E., Jobanputra, V., Lyon, G. J., Wigler, M., Schatz, M. C. , Narzisi, G. (2016) Indel variant analysis of short-read sequencing data with Scalpel. Nat Protoc, 11(12) pp. 2529-2548.

Andrews, Peter A., Iossifov, Ivan, Kendall, Jude, Marks, Steven, Muthuswamy, Lakshmi, Wang, Zihua, Levy, Dan , Wigler, Michael (2016) MUMdex: MUM-based structural variation detection. bioRxiv, pp. 78261.

Wang, Z., Andrews, P., Kendall, J., Ma, B., Hakker, I., Rodgers, L., Ronemus, M., Wigler, M. , Levy, D. (2016) SMASH, a fragmentation and sequencing method for genomic copy number analysis. Genome Res, 26(6) pp. 844-51.

Baslan, T., Kendall, J., Rodgers, L., Cox, H., Riggs, M., Stepansky, A., Troge, J., Ravi, K., Esposito, D., Lakshmi, B., Wigler, M., Navin, N. , Hicks, J. (2016) Corrigendum: Genome-wide copy number analysis of single cells. Nat Protoc, 11(3) pp. 616.

Garvin, T., Aboukhalil, R., Kendall, J., Baslan, T., Atwal, G. S., Hicks, J., Wigler, M. , Schatz, M. C. (2015) Interactive analysis and assessment of single-cell copy-number variations. Nat Methods, 12 pp. 1058-1060.

Iossifov, I., Levy, D., Allen, J., Ye, K., Ronemus, M., Lee, Y. H., Yamrom, B. , Wigler, M. (2015) Low load for disruptive mutations in autism genes and their biased transmission. Proc Natl Acad Sci U S A,

Baslan, T., Kendall, J., Ward, B., Cox, H., Leotta, A., Rodgers, L., Riggs, M., D'Italia, S., Sun, G., Yong, M., Miskimen, K., Gilmore, H., Saborowski, M., Dimitrova, N., Krasnitz, A., Harris, L., Wigler, M. , Hicks, J. (2015) Optimizing sparse sequencing of single cells for highly multiplex copy number profiling. Genome Research, 25(5) pp. 714-724.

Rye, I. H., Lundin, P., Maner, S., Fjelldal, R., Naume, B., Wigler, M., Hicks, J., Borresen-Dale, A. L., Zetterberg, A. , Russnes, H. G. (2015) Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors. Genes, Chromosomes & Cancer, 54(4) pp. 235-48.

Mukhopadhyay, Swagatam, Wigler, Michael , Levy, Dan (2015) Simple genetic models for autism spectrum disorder. bioRxiv, pp. 17301.

Jayaprakash, A. D., Benson, E. K., Gone, S., Liang, R., Shim, J., Lambertini, L., Toloue, M. M., Wigler, M., Aaronson, S. A. , Sachidanandam, R. (2015) Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA. Nucleic Acids Research, 43(4) pp. 2177-2187.

Garvin, Tyler, Aboukhalil, Robert, Kendall, Jude, Baslan, Timour, Atwal, Gurinder S, Hicks, James, Wigler, Michael , Schatz, Michael (2015) Interactive analysis and quality assessment of single-cell copy-number variations. Nature Methods, 12 pp. 1058-1060.

Iossifov, I., O'Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., Stessman, H. A., Witherspoon, K. T., Vives, L., Patterson, K. E., Smith, J. D., Paeper, B., Nickerson, D. A., Dea, J., Dong, S., Gonzalez, L. E., Mandell, J. D., Mane, S. M., Murtha, M. T., Sullivan, C. A., Walker, M. F., Waqar, Z., Wei, L., Willsey, A. J., Yamrom, B., Lee, Y. H., Grabowska, E., Dalkic, E., Wang, Z., Marks, S., Andrews, P., Leotta, A., Kendall, J., Hakker, I., Rosenbaum, J., Ma, B., Rodgers, L., Troge, J., Narzisi, G., Yoon, S., Schatz, M. C., Ye, K., McCombie, W. R., Shendure, J., Eichler, E. E., State, M. W. , Wigler, M. (2014) The contribution of de novo coding mutations to autism spectrum disorder. Nature, 515(7526) pp. 216-221.

Levy, D. , Wigler, M. (2014) Facilitated sequence counting and assembly by template mutagenesis. Proceedings of the National Academy of Sciences of the United States of America, 111(43) pp. E4632-E4637.

Narzisi, G., O'Rawe, Jason, Iossifov, I., Fang, Han, Lee, Y. H., Wang, Zihua, Wu, Yiyang, Lyon, Gholson J., Wigler, M. H. , Schatz, M. C. (2014) Accurate de novo and transmitted indel detection in exome-capture data using microassembly. Nature Methods, 11(10) pp. 1033-1036.

Dago, A. E., Stepansky, A., Carlsson, A., Luttgen, M., Kendall, J., Baslan, T., Kolatkar, A., Wigler, M., Bethel, K., Gross, M. E., Hicks, J. , Kuhn, P. (2014) Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells. PLoS One, 9(8) pp. e101777.

Warburton, D., Ronemus, M., Kline, J., Jobanputra, V., Williams, I., Anyane-Yeboa, K., Chung, W., Yu, L., Wong, N., Awad, D., Yu, C. Y., Leotta, A., Kendall, J., Yamrom, B., Lee, Y. H., Wigler, M. , Levy, D. (2014) The contribution of de novo and rare inherited copy number changes to congenital heart disease in an unselected sample of children with conotruncal defects or hypoplastic left heart disease. Human Genetics, 133(1) pp. 11-27.

Ronemus, M., Iossifov, I., Levy, D. , Wigler, M. (2014) The role of de novo mutations in the genetics of autism spectrum disorders. Nature Reviews Genetics, 15(2) pp. 133-141.

Shi, J., Whyte, W. A., Zepeda-Mendoza, C. J., Milazzo, J. P., Shen, C., Roe, J. S., Minder, J. L., Mercan, F., Wang, E., Eckersley-Maslin, M. A., Campbell, A. E., Kawaoka, S., Shareef, S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, R. G., Wigler, M. A., Blobel, G. A., Zuber, J., Spector, D. L., Young, R. A. , Vakoc, C. R. (2013) Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes and Development, 27(24) pp. 264-273.

Wigler, M. H. (2013) Cold Spring Harbor Laboratory Annual Reports Excerpts: Wigler Laboratory 1979-2011. Cold Spring Harbor Laboratory.

Krasnitz, A., Sun, G., Andrews, P. , Wigler, M. (2013) Target inference from collections of genomic intervals. Proceedings of the National Academy of Sciences of the United States of America, 110(25) pp. E2271-E2278.

Donnenberg, A. D., Hicks, J. B., Wigler, M. , Donnenberg, V. S. (2013) The Cancer Stem Cell: Cell Type or Cell State?. Cytometry Part A, 83A(SI 1) pp. 5-7.

Wigler, M. (2012) Broad applications of single-cell nucleic acid analysis in biomedical research. Genome Med, 4(10) pp. 79.

Stadler, Z. K., Esposito, D., Shah, S., Vijai, J., Yamrom, B., Levy, D., Lee, Y. H., Kendall, J., Leotta, A., Ronemus, M., Hansen, N., Sarrel, K., Rau-Murthy, R., Schrader, K., Kauff, N., Klein, R., Lipkin, S., Murali, R., Robson, M., Sheinfeld, J., Feldman, D., Bosl, G., Norton, L., Wigler, M. , Offit, K. (2012) Rare De Novo Germline Copy-Number Variation in Testicular Cancer. The American Journal of Human Genetics, 91(2) pp. 379-383.

Kitzing, T., Xue, W., Roessler, S., Krasnitz, A., Schultz, N., Wang, X. W., Wigler, M. , Lowe, S. W. (2012) Cooperating Tumor Suppressor Genes on Chromosome 8p Predict Survival Outcome in Hepatocellular Carcinoma. European Journal of Cancer, 48 pp. S139-S139.

Baslan, T., Kendall, J. T., Rodgers, L., Cox, H., Riggs, M., Stepansky, A., Troge, J. E., Ravi, K., Esposito, D., Lakshmi, B., Wigler, M., Navin, N. E. , Hicks, J. B. (2012) Genome-wide copy number analysis of single cells. Nat Protoc, 7(6) pp. 1024-41.

Xue, W., Kitzing, T., Roessler, S., Zuber, J., Krasnitz, A., Schultz, N., Revill, K., Weissmueller, S., Rappaport, A. R., Simon, J., Zhang, J., Luo, W. J., Hicks, J., Zender, L., Wang, X. W., Powers, S., Wigler, M. , Lowe, S. W. (2012) A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proceedings of the National Academy of Sciences of the United States of America, 109(21) pp. 8212-8217.

Iossifov, I., Ronemus, M., Levy, D., Wang, Z. H., Hakker, I., Rosenbaum, J., Yamrom, B., Lee, Y. H., Narzisi, G., Leotta, A., Kendall, J., Grabowska, E., Ma, B. C., Marks, S., Rodgers, L., Stepansky, A., Troge, J., Andrews, P., Bekritsky, M., Pradhan, K., Ghiban, E., Kramer, M., Parla, J., Demeter, R., Fulton, L. L., Fulton, R. S., Magrini, V. J., Ye, K., Darnell, J. C., Darnell, R. B., Mardis, E. R., Wilson, R. K., Schatz, M. C., McCombie, W. R. , Wigler, M. (2012) De Novo Gene Disruptions in Children on the Autistic Spectrum. Neuron, 74(2) pp. 285-299.

Lee, Y. H., Ronemus, M., Kendall, J., Lakshmi, B., Leotta, A., Levy, D., Esposito, D., Grubor, V., Ye, K., Wigler, M. , Yamrom, B. (2012) Reducing system noise in copy number data using principal components of self-self hybridizations. Proceedings of the National Academy of Sciences of the United States of America, 109(3) pp. E103-E110.

Horev, G., Ellegood, J., Lerch, J. P., Son, Y. E., Muthuswamy, L., Vogel, H., Krieger, A. M., Buja, A., Henkelman, R. M., Wigler, M. H. , Mills, A. A. (2011) Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proceedings of the National Academy of Sciences of the United States of America, 108(41) pp. 17076-81.

Gilman, S. R, Iossifov, I., Levy, D., Ronemus, M., Wigler, M. H. , Vitkup, D. (2011) Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses. Neuron, 70(5) pp. 898-907.

Levy, D., Ronemus, M., Yamrom, B., Lee, Y. H., Leotta, A., Kendall, J. T., Marks, S., Lakshmi, B., Pai, D., Ye, Kenny, Buja, Andreas, Krieger, Abba, Yoon, S., Troge, J. E., Rodgers,  L., Iossifov, I. , Wigler, M. H. (2011) Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders. Neuron, 70(5) pp. 886-897.

Lee, Yoon-ha, Ronemus, Michael, Kendall, Jude, Lakshmi, B, Leotta, Anthony, Levy, Dan, Esposito, Diane, Grubor, Vladimir, Ye, Kenny, Wigler, Michael , Yamrom, Boris (2011) Removing System Noise from Comparative Genomic Hybridization Data by Self-Self Analysis.

Kamalakaran, S., Varadan, V., Giercksky Russnes, H. E., Levy, D., Kendall, J. T., Janevski, A., Riggs, M., Banerjee, N., Synnestvedt, M., Schlichting, E., Kåresen, R., Shama Prasada, K., Rotti, H., Rao, R., Rao, L., Eric Tang, M. H., Satyamoorthy, K., Lucito, R., Wigler, M. H., Dimitrova, N., Naume, B., Borresen-Dale, A. L. , Hicks, J. B. (2011) DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables. Molecular Oncology, 5(1) pp. 77-92.

Navin, N. E., Kendall, J. T., Troge, J. E., Andrews, P., Rodgers,  L., McIndoo, J., Cook, K., Stepansky,  A., Levy, D., Esposito, D., Muthuswamy, L., Krasnitz, A., McCombie, W. R., Hicks, J. B. , Wigler, M. H. (2011) Tumour evolution inferred by single-cell sequencing. Nature, 472(7341) pp. 90-94.

Russnes, H. G., Vollan, H. K. M., Lingjærde, O. C., Krasnitz, A., Lundin, P., Naume, B., Sørlie, T., Borgen, E., Rye, I. H., Langerød, A., Chin, S. F., Teschendorff, A. E., Stephens, P. J., Månér, S., Schlichting, E., Baumbusch, L. O., Kåresen, R., Stratton, M. P., Wigler, M. H., Caldas, C., Zetterberg, A., Hicks, J. B. , Børresen-Dale, A. L. (2010) Genomic architecture characterizes tumor progression paths and fate in breast cancer patients. Science Translational Medicine, 2(38)

Hicks, J. B., Navin, N. E., Kendall, J. T., Levy, D. , Wigler, M. H. (2010) Tracing Tumor Lineage and Progression through Genomic Copy Number Profiling at the Single Cell Level. Annals of Oncology, 21(S4) pp. iv49.

Navin, N. E., Krasnitz, A., Rodgers, L., Cook, K., Meth, J. L., Kendall, J. T., Riggs, M., Eberling, Y., Troge, J. E., Grubor, V., Levy, D., Lundin, P., Månér, S., Zetterberg, A., Hicks, J. B. , Wigler, M. H. (2010) Inferring tumor progression from genomic heterogeneity. Genome Research, 20(1) pp. 68-80.

Bric, A., Miething, C., Bialucha, C. U., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M. H., Hicks, J. B., McCombie, W. R., Hemann, M. T., Hannon, G. J., Powers, S. , Lowe, S. W. (2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell, 16(4) pp. 324-35.

Hodges, E., Smith, A. D., Kendall, J. T., Xuan, Z., Ravi, K., Rooks, M., Zhang, M. Q., Ye, K., Bhattacharjee, A., Brizuela, L., McCombie, W. R., Wigler, M. H., Hannon, G. J. , Hicks, J. B. (2009) High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Research, 19(9) pp. 1593-1605.

McArthur, H. L., Brogi, E., Patil, S., Wigler, M. H., Norton, L., Hicks, J. B. , Hudis, C. A. (2009) High resolution microarray copy number analysis (array CGH) suggests that determination of HER2 amplification by FISH (FISH plus ) is inaccurate in human breast cancer specimens that are HER2 2+by immunohistochemistry (IHC2+). European Journal of Cancer Supplements, 7(2) pp. 88-88.

Hicks, J. B., McArthur, H., Tan, L. K., Patil, S., Wigler, M. H., Hudis, C. , Norton, L. (2009) Topo2a and Her2 Co-Amplification Is Uncommon by High Resolution Representational Oligonucleotide Microarray Analysis (Roma) in Human Breast Cancer. Annals of Oncology, 20(S2) pp. ii22-23.

Russnes, H. G., Vollan, H. K. M., Sorlie, T., Krasnitz, A., Zetterberg, A., Naume, B., Borgen, E., Nesland, J. M., Wigler, M. H., Borresen-Dale, A. L. , Hicks, J. B. (2009) Molecular subclassification of breast carcinomas based on aCGH reveals two major groups of tumors with common genomic, transcriptomic and clinicopathological characteristics. APMIS, 117(3) pp. 238-239.

Grubor, V., Krasnitz, A., Troge, J. E., Meth, J. L., Lakshmi, B., Kendall, J. T., Yamrom, B., Alex, G., Pai, D., Navin, N. E., Hufnagel, L. A., Lee, Y. H., Cook, K., Allen, S. L., Rai, K. R., Damle, R. N., Calissano, C., Chiorazzi, N., Wigler, M. H. , Esposito, D. (2009) Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA). Blood, 113(6) pp. 1294-1303.

McArthur, H. L., Tan, L. K., Patil, S., Wigler, M. H., Hudis, C. A., Hicks, J. B. , Norton, L. (2009) High resolution representational oligonucleotide microarray analysis (ROMA) suggests that TOPO2 and HER2 co-amplification is uncommon in human breast cancer. Cancer Res, 69(2, Sup) pp. 163S-163S.

Gupta, L., Kumar, S., Singh, R., Shaik, R., Dimitrova, N., Gorthi, A., Lakshmi, B., Pai, D., Kamalakaran, S., Zhao, X. , Wigler, M. H. (2008) Classification method for microarray probe selection using sequence, thermodynamics and secondary structure parameters. 19th International Conference on Pattern Recognition,

Zender, L., Xue, W., Zuber, J., Semighini, C. P., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, J. M., Schirmacher, P., McCombie, W. R., Wigler, M. H., Hicks, J. B., Hannon, G. J., Powers, S. , Lowe, S. W. (2008) An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell, 135(5) pp. 852-864.

Grubor, V., Krasnitz, A., Troge, J. E., Meth, J. L., Lakshmi, B., Kendall, J. T., Yamrom, B., Alex, G., Pai, D., Navin, N. E., Hufnagel, L. A., Lee, Y. H., Cook, K., Allen, S. L., Rai, K. R., Damle, R., Calissano, C., Chiorazzi, N., Wigler, M. H. , Esposito, D. (2008) High-Resolution Array-Based Comparative Genome Hybridization (CGH) Identifies Novel and Recurrent Regions in CLL. Blood, 112(11) pp. 717-717.

Russnes, H. G., Sorlie, T., Krasnitz, A., Zetterberg, A., Naume, B., Borgen, E., Nesland, J. M., Wigler, M. H., Borresen-Dale, A. L. , Hicks, J. B. (2008) Molecular subclassification of breast carcinomas based on aCGH, gene expression, IHC and ploidy - relevance for clinical outcome. European Journal of Cancer Supplements, 6(9) pp. 9-9.

Xue, W., Krasnitz, A., Lucito, R., Sordella, R., Van Aelst, L., Cordon-Cardo, C., Singer, S., Kuehnel, F., Wigler, M. H., Powers, S., Zender, L. , Lowe, S. W. (2008) DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development, 22(11) pp. 1439-44.

Alarcon, M., Abrahams, B. S., Stone, J. L., Duvall, J. A., Perederiy, J. V., Bomar, J. M., Sebat, J., Wigler, M. H., Martin, C. L., Ledbetter, D. H., Nelson, S. F., Cantor, R. M. , Geschwind, D. H. (2008) Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene. Am J Hum Genet, 82(1) pp. 150-159.

Egan, C. M., Sridhar, S., Wigler, M. H. , Hall, I. M. (2007) Recurrent DNA copy number variation in the laboratory mouse. Nat Genet, 39(11) pp. 1384-9.

Lucito, R., Suresh, S., Walter, K., Pandey, A., Lakshmi, B., Krasnitz, A., Sebat, J., Wigler, M. H., Klein, A. P., Brune, K., Palmisano, E., Maitra, A., Goggins, M. , Hruban, R. H. (2007) Copy-Number Variants in Patients with a Strong Family History of Pancreatic Cancer. Cancer Biol Ther, 6(10) pp. 1592-9.

Zhao, X., Leotta, A., Kustanovich, V., Lajonchere, C., Geschwind, D. H., Law, K., Law, P., Qiu, S., Lord, C., Sebat, J., Ye, K. , Wigler, M. H. (2007) A unified genetic theory for sporadic and inherited autism. Proc Natl Acad Sci U S A, 104(31) pp. 12831-12836.

Sebat, J., Lakshmi, B., Malhotra, D., Troge, J. E., Lese-Martin, C., Walsh, T., Yamrom, B., Yoon, S., Krasnitz, A., Kendall, J. T., Leotta, A., Pai, D., Zhang, R., Lee, Y. H., Hicks, J. B., Spence, S. J., Lee, A. T., Puura, K., Lehtimaki, T., Ledbetter, D., Gregersen, P. K., Bregman, J., Sutcliffe, J. S., Jobanputra, V., Chung, W., Warburton, D., King, M. C., Skuse, D., Geschwind, D. H., Gilliam, T. C., Ye, K. , Wigler, M. H. (2007) Strong Association of De Novo Copy Number Mutations with Autism. Science, 316(5823) pp. 445-449.

Hicks, J. B., Krasnitz, A., Lakshmi, B., Navin, N. E., Riggs, M., Leibu, E., Esposito, D., Alexander, J., Troge, J. E., Grubor, V., Yoon, S., Wigler, M. H., Ye, K., Borresen-Dale, A. L., Naume, B., Schlicting, E., Norton, L., Hagerstrom, T., Skoog, L., Auer, G., Månér, S., Lundin, P. , Zetterberg, A. (2006) Novel patterns of genome rearrangement and their association with survival in breast cancer. Genome Research, 16(12) pp. 1465-79.

Pelham, R. J., Rodgers, L., Hall, I. M., Lucito, R., Nguyen, K. C. Q., Navin, N. E., Hicks, J. B., Mu, D., Powers, S., Wigler, M. H. , Botstein, D. (2006) Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proc Natl Acad Sci U S A, 103(52) pp. 19848-19853.

Sebat, J., Lakshmi, B., Troge, J., Martin, C., Spence, S., Ledbetter, D., Gilliam, T. C., Ye, K., Geschwind, D., Sutcliffe, J. , Wigler, M. H. (2006) High-resolution analysis of genome copy number variation in autism. International Journal of Developmental Neuroscience, 24(8) pp. 474.

Grubor, V. D., Troge, J. E., Meth, J. L., Lakshmi, B., Yamron, B., Hufnagel, L. A., Lee, Y. H., Kendall, J. T., Pai, D., Lee, A., Gregersen, P., Yancopoulos, S., Allen, S., Rai, K. R., Chiorazzi, N., Wigler, M. H. , Esposito, D. (2006) Genome Analysis of CLL by Representational Oligonucleotide Microarray Analysis (ROMA). ASH Annual Meeting Abstracts, 108(11) pp. 2085.

Navin, N. E., Grubor, V., Hicks, J. B., Leibu, E., Thomas, E., Troge, J., Riggs, M., Lundin, P., Månér, S., Sebat, J., Zetterberg, A. , Wigler, M. H. (2006) PROBER: oligonucleotide FISH probe design software. Bioinformatics, 22(19) pp. 2437-8.

Lakshmi, B., Hall, I. M., Egan, C., Alexander, J., Leotta, A., Healy, J., Zender, L., Spector, M. S., Xue, W., Lowe, S. W., Wigler, M. H. , Lucito, R. (2006) Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. Proc Natl Acad Sci U S A, 103(30) pp. 11234-9.

Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S. T., Luk, J. M., Wigler, M. H., Hannon, G. J., Mu, D., Lucito, R., Powers, S. , Lowe, S. W. (2006) Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell, 125(7) pp. 1253-67.

West, J., Healy, J., Wigler, M. H., Casey, W. , Mishra, B. (2006) Validation of S. Pombe sequence assembly by microarray hybridization. J Comput Biol, 13(1) pp. 1-20.

Sachs, N. A., Holmes, S. E., Cowell, J. K., Conroy, J., Nowak, N. J., McQuaid, D., Rossi, M. R., Gaile, D. P., Christian, S. L., Wigler, M. H., Sebat, J., Ross, C. A., DeLisi, L. E. , Margolis, R. L. (2005) Assessment of schizophrenia genomes for DNA copy number alterations. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 138B(1) pp. 90-91.

Jobanputra, V., Sebat, J., Troge, J., Chung, W., Anyane-Yeboa, K., Wigler, M. H. , Warburton, D. (2005) Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements. Genetics in Medicine, 7(2) pp. 111-118.

Hicks, J. B., Muthuswamy, L., Krasnitz, A., Navin, N. E., Riggs, M., Grubor, V., Esposito, D., Alexander, J., Troge, J. E., Wigler, M. H., Maner, S., Lundin, P. , Zetterberg, A. (2005) High-resolution ROMA CGH and FISH analysis of aneuploid and diploid breast tumors. Cold Spring Harb Symp Quant Biol, 70 pp. 51-63.

Daruwala, R. S., Rudra, A., Ostrer, H., Lucito, R., Wigler, M. H. , Mishra, B. (2004) A versatile statistical analysis algorithm to detect genome copy number variation. Proceedings of the National Academy of Sciences of the United States of America, 101(46) pp. 16292-16297.

Olshen, A. B., Venkatraman, E. S., Lucito, R. , Wigler, M. H. (2004) Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics, 5(4) pp. 557-572.

Sebat, J., Lakshmi, B., Troge, J. E., Alexander, J., Young, J., Lundin, P., Maner, S., Massa, H., Walker, M., Chi, M., Navin, N. E., Lucito, R., Healy, J., Hicks, J. B., Ye, K., Reiner, A., Gilliam, T. C., Trask, B., Patterson, N., Zetterberg, A. , Wigler, M. H. (2004) Large-scale copy number polymorphism in the human genome. Science, 305(5683) pp. 525-8.

Thomas, E. E., Srebro, N., Sebat, J., Navin, N., Healy, J., Mishra, B. , Wigler, M. H. (2004) Distribution of short paired duplications in mammalian genomes. Proc Natl Acad Sci U S A, 101(28) pp. 10349-54.

Healy, J., Thomas, E. E., Schwartz, J. T. , Wigler, M. H. (2003) Annotating large genomes with exact word matches. Genome Research, 13(10) pp. 2306-2315.

Lucito, R., Healy, J., Alexander, J., Reiner, A., Esposito, D., Chi, M. Y., Rodgers, L., Brady, A., Sebat, J., Troge, J. E., West, J. A., Rostan, S., Nguyen, K. C. Q., Powers, S., Ye, K. Q., Olshen, A., Venkatraman, E., Norton, L. , Wigler, M. H. (2003) Representational oligonucleotide microarray analysis: A high-resolution method to detect genome copy number variation. Genome Research, 13(10) pp. 2291-2305.

Mu, D., Chen, L. Y., Zhang, X. P., See, L. H., Koch, C. M., Yen, C., Tong, J. J., Spiegel, L., Nguyen, K. C. Q., Servoss, A., Peng, Y., Pei, L., Marks, J. R., Lowe, S. W., Hoey, T., Jan, L. Y., McCombie, W. R., Wigler, M. H. , Powers, S. (2003) Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell, 3(3) pp. 297-302.

Hamaguchi, M., Meth, J. L., von Klitzing, C., Wei, W., Esposito, D., Rodgers, L., Walsh, T., Welcsh, P., King, M. C. , Wigler, M. H. (2002) DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 99(21) pp. 13647-13652.

Wigler, M. H. , Mishra, B. (2002) Genetics. Wild by nature. Science, 296(5572) pp. 1407-1408.

Scheffzek, K., Grunewald, P., Wohlgemuth, S., Kabsch, W., Tu, H., Wigler, M. H., Wittinghofer, A. , Herrmann, C. (2001) The Ras-Byr2RBD complex: Structural basis for Ras effector recognition in yeast. Structure, 9(11) pp. 1043-1050.

Stolarov, J., Chang, K., Reiner, A., Rodgers, L., Hannon, G. J., Wigler, M. H. , Mittal, V. (2001) Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America, 98(23) pp. 13043-13048.

Wen, S. H., Stolarov, J., Myers, M. P., Su, J. D., Wigler, M. H., Tonks, N. K. , Durden, D. L. (2001) PTEN controls tumor-induced angiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 98(8) pp. 4622-4627.

Lucito, R., West, J., Reiner, A., Alexander, J., Esposito, D., Mishra, B., Powers, S., Norton, L. , Wigler, M. H. (2000) Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations. Genome Research, 10(11) pp. 1726-1736.

Dong, D. L., Liu, R., Sherlock, R., Wigler, M. H. , Nestler, H. P. (1999) Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyl terminus. Chem Biol, 6(3) pp. 133-41.

Tu, H. , Wigler, M. H. (1999) Genetic evidence for Pak1 autoinhibition and its release by Cdc42. Mol Cell Biol, 19(1) pp. 602-11.

Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, J., Stolarov, J. P., Hemmings, B. A., Wigler, M. H., Downes, C. P. , Tonks, N. K. (1998) The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A, 95(23) pp. 13513-8.

Webb, C. P., Van Aelst, L., Wigler, M. H. , Woude, G. F. (1998) Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc Natl Acad Sci U S A, 95(15) pp. 8773-8.

Lucito, R., Nakimura, M., West, J. A., Han, Y., Chin, K., Jensen, K. R., McCombie, R. W., Gray, J. W. , Wigler, M. H. (1998) Genetic analysis using genomic representations. Proceedings of the National Academy of Sciences of the United States of America, 95(8) pp. 4487-92.

Hamaguchi, M., O'Connor, E. A., Chen, T., Parnell, L., McCombie, R. W. , Wigler, M. H. (1998) Rapid isolation of cDNA by hybridization. Proceedings of the National Academy of Sciences of the United States of America, 95(7) pp. 3764-9.

Tu, H., Barr, M., Dong, D. L. , Wigler, M. H. (1997) Multiple regulatory domains on the Byr2 protein kinase. Mol Cell Biol, 17(10) pp. 5876-87.

Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R. , Tonks, N. K. (1997) P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A, 94(17) pp. 9052-7.

Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H. , Parsons, R. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 275(5308) pp. 1943-7.

Barr, M. M., Tu, H., Van Aelst, L. , Wigler, M. H. (1996) Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe. Mol Cell Biol, 16(10) pp. 5597-603.

White, M. A., Vale, T., Camonis, J. H., Schaefer, E. , Wigler, M. H. (1996) A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. J Biol Chem, 271(28) pp. 16439-42.

Thiagalingam, S., Lisitsyn, N. A., Hamaguchi, M., Wigler, M. H., Willson, J. K., Markowitz, S. D., Leach, F. S., Kinzler, K. W. , Vogelstein, B. (1996) Evaluation of the FHIT gene in colorectal cancers. Cancer Res, 56(13) pp. 2936-9.

Khosravi-Far, R., White, M. A., Westwick, J. K., Solski, P. A., Chrzanowska-Wodnicka, M., Van Aelst, L., Wigler, M. H. , Der, C. J. (1996) Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol, 16(7) pp. 3923-33.

Joneson, T., White, M. A., Wigler, M. H. , Bar-Sagi, D. (1996) Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science, 271(5250) pp. 810-812.

Xu, H. P., Yanak, B. L., Wigler, M. H. , Gorin, M. B. (1996) New polymorphic markers in the vicinity of the pearl locus on mouse chromosome 13. Mamm Genome, 7(1) pp. 16-9.

Marcus, S., Polverino, A., Chang, E., Robbins, D., Cobb, M. H. , Wigler, M. H. (1995) Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A, 92(13) pp. 6180-4.

Jung, V., Chen, L., Hofmann, S. L., Wigler, M. H. , Powers, S. (1995) Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins. Mol Cell Biol, 15(3) pp. 1333-42.

White, M. A., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M. , Wigler, M. H. (1995) Multiple Ras functions can contribute to mammalian cell transformation. Cell, 80(4) pp. 533-41.

Lisitsyn, N. A., Lisitsina, N. M., Dalbagni, G., Barker, P., Sanchez, C. A., Gnarra, J., Linehan, W. M., Reid, B. J. , Wigler, M. H. (1995) Comparative genomic analysis of tumors: detection of DNA losses and amplification. Proc Natl Acad Sci U S A, 92(1) pp. 151-5.

Lisitsyn, N. , Wigler, M. H. (1995) Representational difference analysis in detection of genetic lesions in cancer. Methods Enzymol, 254 pp. 291-304.

Chang, E. C., Barr, M., Wang, Y., Jung, V., Xu, H. P. , Wigler, M. H. (1994) Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell, 79(1) pp. 131-41.

Marcus, S., Polverino, A., Barr, M. , Wigler, M. H. (1994) Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. Proc Natl Acad Sci U S A, 91(16) pp. 7762-6.

Jung, V., Wei, W., Ballester, R., Camonis, J., Mi, S., Van Aelst, L., Wigler, M. H. , Broek, D. (1994) Two types of RAS mutants that dominantly interfere with activators of RAS. Mol Cell Biol, 14(6) pp. 3707-18.

Marcus, S., Polverino, A., Robbins, D., Cobb, M. , Wigler, M. H. (1994) Conservation of Ste20-Related Protein-Kinases in Eukaryotes. Faseb Journal, 8(7) pp. A1431-A1431.

Lisitsyn, N. A., Segre, J. A., Kusumi, K., Lisitsyn, N. M., Nadeau, J. H., Frankel, W. N., Wigler, M. H. , Lander, E. S. (1994) Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis. Nat Genet, 6(1) pp. 57-63.

Xu, H. P., White, M., Marcus, S. , Wigler, M. H. (1994) Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe. Mol Cell Biol, 14(1) pp. 50-8.

Lisitsyn, N. A., Leach, F. S., Vogelstein, B. , Wigler, M. H. (1994) Detection of genetic loss in tumors by representational difference analysis. Cold Spring Harbor Symposia on Quantitative Biology, 59 pp. 585-7.

Van Aelst, L., White, M. , Wigler, M. H. (1994) Ras partners. Cold Spring Harbor Symposia on Quantitative Biology, 59 pp. 181-186.

Ohlmeyer, M. H. J., Swanson, R. N., Dillard, L. W., Reader, J. C., Asouline, G., Kobayashi, R., Wigler, M. H. , Still, W. C. (1993) Complex synthetic chemical libraries indexed with molecular tags. Proceedings of the National Academy of Sciences of the United States of America, 90(23) pp. 10922-10926.

Bolger, G., Michaeli, T., Martins, T., St John, T., Steiner, B., Rodgers, L., Riggs, M., Wigler, M. H. , Ferguson, K. (1993) A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol Cell Biol, 13(10) pp. 6558-71.

Van Aelst, L., Barr, M., Marcus, S., Polverino, A. , Wigler, M. H. (1993) Complex formation between RAS and RAF and other protein kinases. Proc Natl Acad Sci U S A, 90(13) pp. 6213-7.

Michaeli, T., Bloom, T. J., Martins, T., Loughney, K., Ferguson, K., Riggs, M., Rodgers, L., Beavo, J. A. , Wigler, M. H. (1993) Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase- deficient Saccharomyces cerevisiae. Journal of Biological Chemistry, 268(17) pp. 12925-12932.

Chardin, P., Camonis, J. H., Gale, N. W., van Aelst, L., Schlessinger, J., Wigler, M. H. , Bar-Sagi, D. (1993) Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science, 260(5112) pp. 1338-1343.

Wigler, M. H., Xu, H. P., Vanaelst, L., Jung, V., Marcus, S., Polverino, T., Oneill, K., Chang, E., Camonis, J., Nicolette, C., White, M. , Ballester, R. (1993) Evolution of Ras Signal Transduction Pathways. Faseb Journal, 7(7) pp. A1124-A1124.

Gutmann, D. H., Boguski, M., Marchuk, D., Wigler, M. H., Collins, F. S. , Ballester, R. (1993) Analysis of the neurofibromatosis type-1 (NF1) GAP-related domain by site-directed mutagenesis. Oncogene, 8(3) pp. 761-769.

Lisitsyn, N., Lisitsyn, N. , Wigler, M. H. (1993) Cloning the differences between two complex genomes. Science, 259(5097) pp. 946-51.

Andersen, L. B., Ballester, R., Marchuk, D. A., Chang, E., Gutmann, D. H., Saulino, A. M., Camonis, J., Wigler, M. H. , Collins, F. S. (1993) A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. Molecular and Cellular Biology, 13(1) pp. 487-495.

Neiman, A. M., Stevenson, B. J., Xu, H. P., Sprague, G. F., Herskowitz, I., Wigler, M. H. , Marcus, S. (1993) Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Molecular Biology of the Cell, 4(1) pp. 107-120.

Marcus, S., Wigler, M. H., Xu, H. P., Ballester, R., Kawamukai, M. , Polverino, A. (1993) RAS function and protein kinase cascades. Ciba Found Symp, 176 pp. 53-61; discussion 61.

Shibuya, E. K., Polverino, A. J., Chang, E., Wigler, M. H. , Ruderman, J. V. (1992) Oncogenic Ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America, 89(20) pp. 9831-9835.

Xu, H. P., Rajavashisth, T., Grewal, N., Jung, V., Riggs, M., Rodgers, L. , Wigler, M. H. (1992) A gene encoding a protein with seven zinc finger domains acts on the sexual differentiation pathways of Schizosaccharomyces pombe. Mol Biol Cell, 3(7) pp. 721-34.

Gerst, J. E., Rodgers, L., Riggs, M. , Wigler, M. (1992) SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes. Proc Natl Acad Sci U S A, 89(10) pp. 4338-42.

Kawamukai, M., Gerst, J., Field, J., Riggs, M., Rodgers, L., Wigler, M. H. , Young, D. (1992) Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe. Molecular Biology of the Cell, 3(2) pp. 167-180.

Andersen, L., Ballester, R., Marchuk, D., Saulino, A., Wigler, M. H. , Collins, F. (1991) Alternative Splicing in the Proposed Catalytic Domain of the Type-1 Neurofibromatosis Gene. American Journal of Human Genetics, 49(4) pp. 21-21.

Vojtek, A., Haarer, B., Field, J., Gerst, J., Pollard, T. D., Brown, S. , Wigler, M. H. (1991) Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae. Cell, 66(3) pp. 497-505.

Daar, I., Nebreda, A. R., Yew, N., Sass, P., Paules, R., Santos, E., Wigler, M. H. , Vandewoude, G. F. (1991) The Ras Oncoprotein and M-Phase Activity. Science, 253(5015) pp. 74-76.

Wang, Y., Xu, H. P., Riggs, M., Rodgers, L. , Wigler, M. H. (1991) byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype. Molecular & Cellular Biology, 11(7) pp. 3554-63.

Young, D., O'Neill, K., Broek, D. , Wigler, M. H. (1991) The adenylyl cyclase-encoding gene from Saccharomyces kluyveri. Gene, 102(1) pp. 129-32.

Colicelli, J., Nicolette, C., Birchmeier, C., Rodgers, L., Riggs, M. , Wigler, M. H. (1991) Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 88(7) pp. 2913-7.

Gerst, J. E., Ferguson, K., Vojtek, A., Wigler, M. H. , Field, J. (1991) CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex. Molecular & Cellular Biology, 11(3) pp. 1248-57.

Kawamukai, M., Ferguson, K., Wigler, M. H. , Young, D. (1991) Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe. Cell Regulation, 2(2) pp. 155-64.

Vojtek, A., Field, J., Gerst, J. , Wigler, M. H. (1991) The Ras Signalling Pathway in Yeast. Journal of Cellular Biochemistry - Supplement.(15 PART B), pp. 84.

Wang, Y., Boguski, M., Riggs, M., Rodgers, L. , Wigler, M. (1991) sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. Cell Regulation, 2(6) pp. 453-465.

Wigler, M. H., Ballester, R., Chang, E., Colicelli, J., Field, J., Gerst, J., Kawamukai, M., Michaeli, T. , Nicolette, C. (1991) The Ways of Ras. Proceedings American Association for Cancer Research Annual Meeting, pp. 435.

Ballester, R., Marchuk, D., Boguski, M., Saulino, A., Letcher, R., Wigler, M. H. , Collins, F. (1990) The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins . Cell, 63(4) pp. 851-9.

Xu, H. P., Wang, Y., Riggs, M., Rodgers, L. , Wigler, M. H. (1990) Biological activity of the mammalian RAP genes in yeast. Cell Regulation, 1(10) pp. 763-769.

Wigler, M. H. (1990) Oncoproteins. Gaps in Understanding Ras. Nature, 346(6286) pp. 696-697.

Colicelli, J., Field, J., Ballester, R., Chester, N., Young, D. , Wigler, M. H. (1990) Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase. Molecular & Cellular Biology, 10(6) pp. 2539-43.

Field, J., Vojtek, A., Ballester, R., Bolger, G., Colicelli, J., Ferguson, K., Gerst, J., Kataoka, T., Michaeli, T., Powers, S., Riggs, M., Rodgers, L., Wieland, I., Wheland, B. , Wigler, M. H. (1990) Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein. Cell, 61(2) pp. 319-327.

Wieland, I., Bolger, G., Asouline, G. , Wigler, M. H. (1990) A method for difference cloning: gene amplification following subtractive hybridization. Proc Natl Acad Sci U S A, 87(7) pp. 2720-4.

Field, J., Xu, H. P., Michaeli, T., Ballester, R., Sass, P., Wigler, M. H. , Colicelli, J. (1990) Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae. Science, 247(4941) pp. 464-7.

Ballester, R. , Wigler, M. H. (1990) Isolation and Characterization of Genes That Regulate Ras Function in the Yeast Saccharomyces-Cerevisiae. Yeast, 6(SPEC. ) pp. S212.

Birchmeier, C., O'Neill, K., Riggs, M. , Wigler, M. H. (1990) Characterization of Ros1 cDNA from a Human Glioblastoma Cell Line. Proceedings of the National Academy of Sciences of the United States of America, 87(12) pp. 4799-4803.

Gerst, J. E., Field, J., Ferguson, K. , Wigler, M. H. (1990) Molecular and Phenotypic Analysis of Cap a Regulatory Element Involved in Mediating Both Ras Action and Amino Acid Balance. Yeast, 6(SPEC. ) pp. S174.

Xu, H. P., Riggs, M., Rodgers, L. , Wigler, M. H. (1990) A gene from Schizosaccharomyces-Pombe with homology to Escherichia-Coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells. Nucleic Acids Research, 18(17) pp. 5304.

Ballester, R., Michaeli, T., Ferguson, K., Xu, H. P., McCormick, F. , Wigler, M. H. (1989) Genetic analysis of mammalian GAP expressed in yeast. Cell, 59(4) pp. 681-6.

Michaeli, T., Field, J., Ballester, R., O'Neill, K. , Wigler, M. H. (1989) Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae. Embo J, 8(10) pp. 3039-44.

Young, D., Riggs, M., Field, J., Vojtek, A., Broek, D. , Wigler, M. H. (1989) The adenylyl cyclase gene from Schizosaccharomyces pombe. Proc Natl Acad Sci U S A, 86(20) pp. 7989-93.

Colicelli, J., Birchmeier, C., Michaeli, T., O'Neill, K., Riggs, M. , Wigler, M. H. (1989) Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Proc Natl Acad Sci U S A, 86(10) pp. 3599-603.

Powers, S., O'Neill, K. , Wigler, M. H. (1989) Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae. Molecular & Cellular Biology, 9(2) pp. 390-5.

Sharma, S., Birchmeier, C., Nikawa, J., O'Neill, K., Rodgers, L. , Wigler, M. H. (1989) Characterization of the ros1-gene products expressed in human glioblastoma cell lines. Oncogene Res, 5(2) pp. 91-100.

Young, D., O'Neill, K., Jessell, T. , Wigler, M. H. (1988) Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain. Proc Natl Acad Sci U S A, 85(14) pp. 5339-42.

Cameron, S., Levin, L., Zoller, M. , Wigler, M. H. (1988) cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell, 53(4) pp. 555-66.

Field, J., Nikawa, J., Broek, D., MacDonald, B., Rodgers, L., Wilson, I. A., Lerner, R. A. , Wigler, M. H. (1988) Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Molecular & Cellular Biology, 8(5) pp. 2159-65.

Toda, T., Cameron, S., Sass, P. , Wigler, M. H. (1988) SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes Dev, 2(5) pp. 517-27.

Levin, L. R., Kuret, J., Johnson, K. E., Powers, S., Cameron, S., Michaeli, T., Wigler, M. H. , Zoller, M. J. (1988) A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation. Science, 240(4848) pp. 68-70.

Wigler, M. H., Cameron, S., Powers, S., Field, J., Toda, T., Broek, D., Nikawa, J., Michaelis, T. , Colicelli, J. (1988) Integration of Ras and Adenylate Cyclase Pathways in Yeast. Journal of Cell Biology, 107(6 PART) pp. 4A.

Wigler, M. H., Field, J., Powers, S., Broek, D., Toda, T., Cameron, S., Nikawa, J., Michaeli, T., Colicelli, J. , Ferguson, K. (1988) Studies of RAS function in the yeast Saccharomyces cerevisiae. Cold Spring Harbor Symposia on Quantitative Biology, 53(2) pp. 649-55.

Birchmeier, C., Sharma, S. , Wigler, M. H. (1987) Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proc Natl Acad Sci U S A, 84(24) pp. 9270-4.

Nikawa, J., Cameron, S., Toda, T., Ferguson, K. M. , Wigler, M. H. (1987) Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes & Development, 1(9) pp. 931-937.

Nikawa, J., Sass, P. , Wigler, M. H. (1987) Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. Molecular & Cellular Biology, 7(10) pp. 3629-36.

Rabin, M., Birnbaum, D., Young, D., Birchmeier, C., Wigler, M. H. , Ruddle, F. H. (1987) Human ROS1 and MAS1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements. Oncogene Res, 1(2) pp. 169-78.

Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J. D., McMullen, B., Hurwitz, M., Krebs, E. G. , Wigler, M. H. (1987) Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Molecular & Cellular Biology, 7(4) pp. 1371-1377.

Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S. , Wigler, M. H. (1987) The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway . Cell, 48(5) pp. 789-800.

Field, J., Broek, D., Kataoka, T. , Wigler, M. H. (1987) Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae. Molecular & Cellular Biology, 7(6) pp. 2128-2133.

Johnson, K. E., Cameron, S., Toda, T., Wigler, M. H. , Zoller, M. J. (1987) Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae. . Journal of Biological Chemistry, 262(18) pp. 8636-8642.

Michaelis, S., Anna, S. S., Powers, S., Wigler, M. H. , Herskowitz, I. (1987) Yeast Mating Pheromone a-Factor and Its Relationship to Ras Proteins. Journal of Cellular Biochemistry, pp. 261-261.

Toda, T., Cameron, S., Sass, P., Zoller, M. , Wigler, M. H. (1987) Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase . Cell, 50(2) pp. 277-288.

Herlands, L., Kishimoto, T., Birchmeier, C., Wigler, M. H. , Koide, S. S. (1986) Induction of Oocyte Maturation by Injection of Oncogenic H-Ras Protein in the Starfish. Zoological Science, 3(6) pp. 1036-1036.

Birchmeier, C., Young, D. , Wigler, M. H. (1986) Characterization of two new human oncogenes. Cold Spring Harbor Symposia on Quantitative Biology, 51(2) pp. 993-1000.

Birchmeier, C., Birnbaum, D., Waitches, G., Fasano, O. , Wigler, M. H. (1986) Characterization of an activated human ros gene. Molecular & Cellular Biology, 6(9) pp. 3109-3116.

Powers, S., Michaelis, S., Broek, D., Ann-A, S. S., Field, J., Herskowitz, I. , Wigler, M. H. (1986) RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell, 47(3) pp. 413-422.

Sass, P., Field, J., Nikawa, J., Toda, T. , Wigler, M. H. (1986) Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae . Proceedings of the National Academy of Sciences of the United States of America, 83(24) pp. 9303-9307.

Young, D., Waitches, G., Birchmeier, C., Fasano, O. , Wigler, M. H. (1986) Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains . Cell, 45(5) pp. 711-720.

Birchmeier, C., Broek, D. , Wigler, M. H. (1985) RAS proteins can induce meiosis in Xenopus oocytes . Cell, 43(3 PART) pp. 615-622.

Kataoka, T., Broek, D. , Wigler, M. H. (1985) DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase. Cell, 43(2) pp. 493-505.

Birchmeier, C., Broek, D., Toda, T., Powers, S., Kataoka, T. , Wigler, M. H. (1985) Conservation and divergence of RAS protein function during evolution. Cold Spring Harbor Symposia on Quantitative Biology, 50 pp. 721-725.

Broach, J., Toda, T., Kataoka, T., Powers, S., Broek, D. , Wigler, M. H. (1985) Ras Proteins Function Exclusively to Modulate Adenylate-Cyclase Activity in the Yeast Saccharomyces. DNA-a Journal of Molecular & Cellular Biology, 4(1) pp. 64-64.

Broek, D., Samily, N., Fasano, O., Fujiyama, A., Tamanoi, F., Northup, J. , Wigler, M. H. (1985) Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins . Cell, 41(3) pp. 763-770.

Feramisco, J., Sullivan, N., Kamata, T., Barsagi, D., Welch, W., Gross, M., Sweet, R., Rosenberg, M., Sathe, G., Fasano, O., Goldfarb, M., Wigler, M. H., Nitecki, D., Clark, R., Arnheim, N. , McCormick, F. (1985) Microinjection of Ras Oncogene Proteins and Inhibitory Antibodies Specific for the Ras Oncogene Proteins into Living Normal and Transformed-Cells. Federation Proceedings, 44(5) pp. 1768-1768.

Gross, M., Sweet, R. W., Sathe, G., Yokoyama, S., Fasano, O., Goldfarb, M., Wigler, M. H. , Rosenberg, M. (1985) Purification and characterization of human H-RAS proteins expressed in Escherichia coli. Molecular and Cellular Biology, 5(5) pp. 1015-1024.

Kataoka, T., Powers, S., Cameron, S., Fasano, O., Goldfarb, M., Broach, J. , Wigler, M. H. (1985) Functional homology of mammalian and yeast RAS genes. Cell, 40(1) pp. 19-26.

Powers, S., Kataoka, T., Toda, T., Fasano, O. , Wigler, M. H. (1985) Control of Yeast Adenyl-Cyclase by Ras Proteins. Federation Proceedings, 44(3) pp. R8-R8.

Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K. , Wigler, M. H. (1985) In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell, 40(1) pp. 27-36.

Fasano, O., Birnbaum, D., Edlund, L., Fogh, J. , Wigler, M. H. (1984) New human transforming genes detected by a tumorigenicity assay. Molecular & Cellular Biology, 4(9) pp. 1695-1705.

Kataoka, T., Powers, S., McGill, C., Fasano, O., Strathern, J., Broach, J. , Wigler, M. H. (1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell, 37(2) pp. 437-445.

Powers, S., Kataoka, T., Fasano, O., Goldfarb, M., Strathern, J., Broach, J. , Wigler, M. H. (1984) Genes in Saccharomyces cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell, 36(3) pp. 607-612.

Fasano, O., Aldrich, T., Tamanoi, F., Taparowsky, E., Furth, M. , Wigler, M. H. (1984) Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proceedings of the National Academy of Sciences of the United States of America, 81(13) pp. 4008-4012.

Meyers, D. A., Antonarakis, S. E., Fearon, E. R., Mallonee, R. L., Waber, P. G., Phillips, J. A., Kazazian, H. H., Levine, M., Kronenberg, H. M., Wigler, M. H. , Ullrich, A. (1984) Use of DNA Polymorphisms to Establish the Linkage Map of the Pth, Beta-Globin, C-Ha-Ras-1, and Insulin Loci on 11p. Cytogenetics and Cell Genetics, 37(1-4) pp. 540-541.

Tamanoi, F., Walsh, M., Kataoka, T. , Wigler, M. H. (1984) A product of yeast RAS-2 gene is a guanine nucleotide binding protein. Proceedings of the National Academy of Sciences of the United States of America, 81(22) pp. 6924-6928.

Wigler, M. H., Fasano, O., Taparowsky, E., Birnbaum, D., Goldfarb, M. , Fogh, J. (1984) Human Transforming Genes. DNA-a Journal of Molecular & Cellular Biology, 3(1) pp. 65-65.

Barker, D., McCoy, M., Weinberg, R., Goldfarb, M., Wigler, M. H., Burt, R., Gardner, E. , White, R. (1983) A test of the role of two oncogenes in inherited predisposition to colon cancer. Mol Biol Med, 1(2) pp. 199-206.

Shimizu, K., Birnbaum, D., Ruley, M. A., Fasano, O., Suard, Y., Edlund, L., Taparowsky, E., Goldfarb, M. , Wigler, M. H. (1983) Structure of the Ki-Ras Gene of the Human-Lung Carcinoma Cell-Line Calu-1. Nature, 304(5926) pp. 497-500.

Shimizu, K., Goldfarb, M., Suard, Y., Perucho, M., Li, Y., Kamata, T., Feramisco, J., Stavnezer, E., Fogh, J. , Wigler, M. H. (1983) Three human transforming genes are related to the viral ras oncogenes. Proceedings of the National Academy of Sciences of the United States of America, 80(8) pp. 2112-2116.

Shimizu, K., Goldfarb, M., Perucho, M. , Wigler, M. H. (1983) Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A, 80(2) pp. 383-387.

Fasano, O., Taparowsky, E., Fiddes, J., Wigler, M. H. , Goldfarb, M. (1983) Sequence and Structure of the Coding Regions of the Human H-Ras-1 Gene from T-24 Bladder Carcinoma Cells. Journal of Molecular & Applied Genetics, 2(2) pp. 173-180.

Kwoh, T. J., Zipser, D. , Wigler, M. H. (1983) Mutational analysis of the cloned chicken thymidine kinase gene. J Mol Appl Genet, 2(2) pp. 191-200.

Ryan, J., Barker, P. E., Shimizu, K., Wigler, M. H. , Ruddle, F. H. (1983) Chromosomal Assignment of a Family of Human Oncogenes. Proc Natl Acad Sci U S A, 80(14) pp. 4460-4463.

Shimizu, K., Taparowsky, E., Fasano, O., Suard, Y., Birnbaum, D., Ruley, M. A., Goldfarb, M. , Wigler, M. H. (1983) Structures of 3 Ras Genes Activated in Human-Tumor Cell-Lines. Journal of Cell Biology, 97(5) pp. A69-A69.

Taparowsky, E., Shimizu, K., Goldfarb, M. , Wigler, M. H. (1983) Structure and Activation of the Human N-Ras Gene. Cell, 34(2) pp. 581-586.

Wigler, M. H., Shimizu, K., Goldfarb, M., Taparowsky, E., Suard, Y. , Fasano, O. (1983) Human Transforming Genes. DNA-a Journal of Molecular & Cellular Biology, 2(1) pp. 64-64.

Goldfarb, M., Shimizu, K., Perucho, M. , Wigler, M. H. (1982) Isolation and Preliminary Characterization of a Human Transforming Gene from T24 Bladder-Carcinoma Cells. Nature, 296(5856) pp. 404-409.

Taparowsky, E., Suard, Y., Fasano, O., Shimizu, K., Goldfarb, M. , Wigler, M. H. (1982) Activation of the T24 Bladder-Carcinoma Transforming Gene Is Linked to a Single Amino-Acid Change. Nature, 300(5894) pp. 762-765.

Perucho, M., Goldfarb, M., Shimizu, K., Lama, C., Fogh, J. , Wigler, M. H. (1981) Human-tumor-derived cell lines contain common and different transforming genes. Cell, 27(3 Pt 2) pp. 467-76.

Perucho, M., Goldfarb, M., Shimizu, K., Lama, C., Fogh, J. , Wigler, M. H. (1981) Human-tumor-derived cell lines contain common and different transforming genes. Cell, 27(3 Pt 2) pp. 467-76.

Perucho, M. , Wigler, M. H. (1981) Linkage and expression of foreign DNA in cultured animal cells. Cold Spring Harb Symp Quant Biol, 45(2) pp. 829-838.

Perucho, M. , Wigler, M. (1981) Linkage and expression of foreign DNA in cultured animal cells. Cold Spring Harb Symp Quant Biol, 45 Pt pp. 829-38.

Wigler, M. H. (1981) The inheritance of methylation patterns in vertebrates. Cell, 24(2) pp. 285-286.

Wigler, M. H., Levy, D. , Perucho, M. (1981) The somatic replication of DNA methylation. Cell, 24(1) pp. 33-40.

Hanahan, D., Lane, D., Lipsich, L., Wigler, M. H. , Botchan, M. (1980) Characteristics of an Sv40-Plasmid Recombinant and Its Movement into and out of the Genome of a Murine Cell. Cell, 21(1) pp. 127-139.

Wigler, M. H., Perucho, M., Kurtz, D., Dana, S., Pellicer, A., Axel, R. , Silverstein, S. (1980) Transformation of mammalian cells with an amplifiable dominant acting gene. Proceedings of the National Academy of Sciences of the United States of America, 77(6) pp. 3567-3570.

Perucho, M., Hanahan, D., Lipsich, L. , Wigler, M. H. (1980) Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature, 285(5762) pp. 207-210.

Klessig, D. F., Wigler, M. H. , Grodzicker, T. (1980) Construction of Co Transformation of Human Cell Lines Which Express Segments of the Adenovirus Genome. Journal of Supramolecular Structure, 9(SUPPL.) pp. 256.

Perucho, M., Hanahan, D. , Wigler, M. H. (1980) Genetic and Physical Linkage of Exogenous Sequences in Transformed-Cells. Cell, 22(1) pp. 309-317.

Wigler, M. H., Perucho, M., Lipsich, L., Lane, D., Klessig, D., Grodzicker, T., Botchan, M. , Hanahan, D. (1980) DNA Mediated Gene Transfer: Theory and Application. Journal of Supramolecular Structure, 9(SUPPL.) pp. 229.

Wold, B., Wigler, M. H., Lacy, E., Maniatis, T., Silverstein, S. , Axel, R. (1979) Introduction and expression of a rabbit Beta-globin gene in mouse fibroblasts. Proceedings of the National Academy of Sciences of the United States of America, 76(11) pp. 5684-5688.

Wigler, M. H., Pellicer, A., Silverstein, S., Axel, R., Urlaub, G. , Chasin, L. (1979) DNA-Mediated Transfer of the Adenine Phosphoribosyltransferase Locus into Mammalian Cells. Proc Natl Acad Sci U S A, 76(3) pp. 1373-1376.

Wigler, M. H., Sweet, R., Sim, G. K., Wold, B., Pellicer, A., Lacy, E., Maniatis, T., Silverstein, S. , Axel, R. (1979) Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell, 16(4) pp. 777-785.

Wigler, M. H., Pellicer, A., Silverstein, S. , Axel, R. (1978) Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell, 14(3) pp. 725-731.

Wigler, M. H., DeFeo, D. , Weinstein, I. B. (1978) Induction of Plasminogen Activator in Cultured Cells by Macrocyclic Plant Diterpene Esters and Other Agents Related to Tumor Promotion. Cancer Res, 38(5) pp. 1434-1437.

Pellicer, A., Wigler, M. H., Axel, R. , Silverstein, S. (1978) The transfer and stable integration of HSV thymidine kinase gene into mouse cells. Cell, 14(1) pp. 133-141.

Weinstein, I. B. , Wigler, M. H. (1977) Cell culture studies provide new information on tumour promoters . Nature, 270(5639) pp. 659-550.

Wigler, M. H., Silverstein, S., Lee, L. S., Pellicer, A., Cheng, Y. C. , Axel, R. (1977) Transfer of Purified Herpes-Virus Thymidine Kinase Gene to Cultured Mouse Cells. Cell, 11(1) pp. 223-232.

Wigler, M. H. , Axel, R. (1976) Nucleosomes in metaphase chromosomes. Nucleic Acids Res, 3(6) pp. 1463-1461.

Wigler, M. H. , Axel, R. (1976) Nucleosomes in metaphase chromosomes. Nucleic Acids Res, 3(6) pp. 1463-1461.

Wigler, M. H. , Weinstein, I. B. (1976) Tumor Promotor Induces Plasminogen Activator. Nature, 259(5540) pp. 232-233.

Wigler, M. H. , Weinstein, I. B. (1976) Tumor Promotor Induces Plasminogen Activator. Nature, 259(5540) pp. 232-233.

Wigler, M. H. , Weinstein, I. B. (1975) Preparative Method for Obtaining Enucleated Mammalian-Cells. Biochemical and Biophysical Research Communications, 63(3) pp. 669-674.