Additional materials of the author at
CSHL Institutional Repository

Henry, Samantha, Lewis, Steven Macauley, Cyrill, Samantha Leeanne, Callaway, Mackenzie Kate, Chatterjee, Deeptiman, Hanasoge Somasundara, Amritha Varshini, Jones, Gina, He, Xue-Yan, Caligiuri, Giuseppina, Ciccone, Michael Francis, Diaz, Isabella Andrea, Biswas, Amelia Aumalika, Hernandez, Evelyn, Ha, Taehoon, Wilkinson, John Erby, Egeblad, Mikala, Tuveson, David Arthur , Dos Santos, Camila Oresco (2024) Host response during unresolved urinary tract infection alters female mammary tissue homeostasis through collagen deposition and TIMP1. Nature Communications, 15(1) pp. 3282.

Boelaars, Kelly, Rodriguez, Ernesto, Huinen, Zowi R, Liu, Chang, Wang, Di, Springer, Babet O, Olesek, Katarzyna, Goossens-Kruijssen, Laura, van Ee, Thomas, Lindijer, Dimitri, Tak, Willemijn, de Haas, Aram, Wehry, Laetitia, Nugteren-Boogaard, Joline P, Mikula, Aleksandra, de Winde, Charlotte M, Mebius, Reina E, Tuveson, David A, Giovannetti, Elisa, Bijlsma, Maarten F, Wuhrer, Manfred, van Vliet, Sandra J , van Kooyk, Yvette (2024) Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions. Communications Biology, 7(1) pp. 430.

Homer, Joshua A, Koelln, Rebecca A, Barrow, Andrew S, Gialelis, Timothy L, Boiarska, Zlata, Steinohrt, Nikita S, Lee, Erinna F, Yang, Wen-Hsuan, Johnson, Robert M, Chung, Taemoon, Habowski, Amber N, Vishwakarma, Dharmendra S, Bhunia, Debmalya, Avanzi, Charlotte, Moorhouse, Adam D, Jackson, Mary, Tuveson, David A, Lyons, Scott K, Lukey, Michael J, Fairlie, W Douglas, Haider, Shozeb M, Steinmetz, Michel O, Prota, Andrea E , Moses, John E (2024) Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chemical Science, 15(11) pp. 3879-3892.

Ubhi, Tajinder, Zaslaver, Olga, Quaile, Andrew T, Plenker, Dennis, Cao, Pinjiang, Pham, Nhu-An, Békési, Angéla, Jang, Gun-Ho, O'Kane, Grainne M, Notta, Faiyaz, Moffat, Jason, Wilson, Julie M, Gallinger, Steven, Vértessy, Beáta G, Tuveson, David A, Röst, Hannes L , Brown, Grant W (2024) Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells. Nature Cancer,

Klingbeil, Olaf, Skopelitis, Damianos, Tonelli, Claudia, Alpsoy, Aktan, Minicozzi, Francesca, Aggarwal, Disha, Russo, Suzanne, Ha, Taehoon, Demerdash, Osama E, Spector, David L, Tuveson, David A, Cifani, Paolo , Vakoc, Christopher R (2024) MARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer. bioRxiv,

Henry, Samantha, Lewis, Steven Macauley, Cyrill, Samantha Leeanne, Callaway, Mackenzie Kate, Chatterjee, Deeptiman, Hanasoge Somasundara, Amritha Varshini, Jones, Gina, He, Xue-Yan, Caligiuri, Giuseppina, Ciccone, Michael Francis, Diaz, Isabella Andrea, Biswas, Amelia, Hernandez, Evelyn, Ha, Taehoon, Wilkinson, John Erby, Egeblad, Mikala, Tuveson, David Arthur , Oresco dos Santos, Camila (2024) Host response during unresolved urinary tract infection alters mammary tissue homeostasis through collagen deposition and TIMP1. bioRxiv,

Amor, Corina, Fernández-Maestre, Inés, Chowdhury, Saria, Ho, Yu-Jui, Nadella, Sandeep, Graham, Courtenay, Carrasco, Sebastian E, Nnuji-John, Emmanuella, Feucht, Judith, Hinterleitner, Clemens, Barthet, Valentin JA, Boyer, Jacob A, Mezzadra, Riccardo, Wereski, Matthew G, Tuveson, David A, Levine, Ross L, Jones, Lee W, Sadelain, Michel , Lowe, Scott W (2024) Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Nature Aging,

Tonelli, Claudia, Yordanov, Georgi N, Hao, Yuan, Deschênes, Astrid, Hinds, Juliene, Belleau, Pascal, Klingbeil, Olaf, Brosnan, Erin, Doshi, Abhishek, Park, Youngkyu, Hruban, Ralph H, Vakoc, Christopher R, Dobin, Alexander, Preall, Jonathan , Tuveson, David A (2024) A mucus production programme promotes classical pancreatic ductal adenocarcinoma. Gut,

Xu, Jihao, Roe, Jae-Seok, Lee, EunJung, Tonelli, Claudia, Ji, Keely Y, Younis, Omar W, Somervile, Tim DD, Yao, Melissa, Milazzo, Joseph P, Tiriac, Herve, Kolarzyk, Anna M, Lee, Esak, Grem, Jean L, Lazenby, Audrey J, Grunkemeyer, James A, Hollingsworth, Michael A, Grandgenett, Paul M, Borowsky, Alexander D, Park, Youngkyu, Vakoc, Christopher R, Tuveson, David A , Hwang, Chang-Il (2023) Engrailed-1 Promotes Pancreatic Cancer Metastasis. Advanced Science, pp. e2308537.

Amor, Corina, Fernández-Maestre, Inés, Chowdhury, Saria, Ho, Yu-Jui, Nadella, Sandeep, Graham, Courtenay, Carrasco, Sebastian E, Nnuji-John, Emmanuella, Feucht, Judith, Hinterleitner, Clemens, Barthet, Valentin JA, Boyer, Jacob A, Mezzadra, Riccardo, Wereski, Matthew G, Tuveson, David A, Levine, Ross L, Jones, Lee W, Sadelain, Michel , Lowe, Scott W (2023) Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Research Square,

Yao, Min, Preall, Jonathan, Yeh, Johannes, Pappin, Darryl J, Cifani, Paolo, Zhao, Yixin, Shen, Sophia, Moresco, Philip, He, Brian, Patel, Hardik, Habowski, Amber N, King, Daniel A, Raphael, Kara L, Rishi, Arvind, Sejpal, Divyesh V, Weiss, Matthew, Tuveson, David , Fearon, Douglas T (2023) Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies to self-antigens. JCI Insight, pp. e172449.

Arteaga, Carlos L, Cleveland, John L, Foti, Margaret, Mesa, Ruben A, Weiner, Louis M, Willman, Cheryl L , Tuveson, David A (2023) AACR Cancer Centers Alliance: Fostering Collaboration and Innovation to Advance Lifesaving Scientific Discoveries for Patients. Molecular Cancer Research, pp. OF1-OF3.

Sroka, Martyna W, Skopelitis, Damianos, Vermunt, Marit W, Preall, Jonathan B, El Demerdash, Osama, de Almeida, Larissa MN, Chang, Kenneth, Utama, Raditya, Gryder, Berkley, Caligiuri, Giuseppina, Ren, Diqiu, Nalbant, Benan, Milazzo, Joseph P, Tuveson, David A, Dobin, Alexander, Hiebert, Scott W, Stengel, Kristy R, Mantovani, Roberto, Khan, Javed, Kohli, Rahul M, Shi, Junwei, Blobel, Gerd A , Vakoc, Christopher R (2023) Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3-FOXO1 in rhabdomyosarcoma. Proceedings of the National Academy of Sciences of USA, 120(36) pp. e2303859120.

Nocini, Riccardo, Tondulli, Luca, D'Ambrosio, Consuelo, Luchini, Claudio, Biankin, Andrew V, Casolino, Raffaella, Scarpa, Aldo, ICGC-ARGO, , Milella, Michele , Lawlor, Rita T (2023) ICGC ARGO precision medicine: genomic profiling-informed prediction of immunotherapy response in two patients with metastatic head and neck squamous cell carcinoma.. The Lancet Oncology, 24(8) pp. 851-853.

Wan, Ledong, Lin, Kuan-Ting, Rahman, Mohammad Alinoor, Ishigami, Yuma, Wang, Zhikai, Jensen, Mads A, Wilkinson, John E, Park, Youngkyu, Tuveson, David A , Krainer, Adrian R (2023) Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer. Cancer Discovery, 13(7) pp. 1678-1695.

Yoo, Hye-Been, Moon, Jin Woo, Kim, Hwa-Ryeon, Lee, Hee Seung, Miyabayashi, Koji, Park, Chan Hee, Ge, Sabrina, Zhang, Amy, Tae, Yoo Keung, Sub, Yujin, Park, Hyun-Woo, Gee, Heon Yung, Notta, Faiyaz, Tuveson, David A, Bang, Seungmin, Kim, Mi-Young , Roe, Jae-Seok (2023) A TEAD2-Driven Endothelial-Like Program Shapes Basal-Like Differentiation and Metastasis of Pancreatic Cancer. Gastroenterology, 165(1) pp. 133-148.e17.

Gialelis, Timothy L, Wang, Zifei, Homer, Joshua A, Yang, Wen-Hsuan, Chung, Taemoon, Hu, Qingting, Smedley, Christopher J, Pawar, Nitin J, Upadhyay, Nitinkumar S, Tuveson, David A, Lyons, Scott K, Lukey, Michael J , Moses, John E (2023) Inhibition of mitochondrial metabolism by (-)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells. MedChemComm, 14(4) pp. 710-714.

Hur, Stella K, Somerville, Tim DD, Wu, Xiaoli S, Maia-Silva, Diogo, Demerdash, Osama E, Tuveson, David A, Notta, Faiyaz , Vakoc, Christopher R (2023) p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinoma. bioRxiv,

Chung, Taemoon, Garcia, Libia, Swamynathan, Manojit M, Froeling, Fieke EM, Trotman, Lloyd C, Tuveson, David A , Lyons, Scott K (2023) Internally Controlled and Dynamic Optical Measures of Functional Tumor Biology. Analytical Chemistry, 95(13) pp. 5661-5670.

Caligiuri, Giuseppina , Tuveson, David A (2023) Activated fibroblasts in cancer: Perspectives and challenges. Cancer Cell, 41(3) pp. 434-449.

Thompson, Dane A, Tsaava, Tea, Rishi, Arvind, Nadella, Sandeep, Mishra, Lopa, Tuveson, David A, Pavlov, Valentin A, Brines, Michael, Tracey, Kevin J , Chavan, Sangeeta S (2023) Optogenetic stimulation of the brainstem dorsal motor nucleus ameliorates acute pancreatitis. Frontiers in Immunology, 14 pp. 1166212.

Belleau, Pascal, Deschênes, Astrid, Chambwe, Nyasha, Tuveson, David A , Krasnitz, Alexander (2022) Genetic ancestry inference from cancer-derived molecular data across genomic and transcriptomic platforms. Cancer Research, pp. CAN-22.

Shaashua, Lee, Ben-Shmuel, Aviad, Pevsner-Fischer, Meirav, Friedman, Gil, Levi-Galibov, Oshrat, Nandakumar, Subhiksha, Barki, Debra, Nevo, Reinat, Brown, Lauren E, Zhang, Wenhan, Stein, Yaniv, Lior, Chen, Kim, Han Sang, Bojmar, Linda, Jarnagin, William R, Lecomte, Nicolas, Mayer, Shimrit, Stok, Roni, Bishara, Hend, Hamodi, Rawand, Levy-Lahad, Ephrat, Golan, Talia, Porco, John A, Iacobuzio-Donahue, Christine A, Schultz, Nikolaus, Tuveson, David A, Lyden, David, Kelsen, David , Scherz-Shouval, Ruth (2022) BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nature Communications, 13(1) pp. 6513.

Bose, Shree, Barroso, Margarida, Chheda, Milan G, Clevers, Hans, Elez, Elena, Kaochar, Salma, Kopetz, Scott E, Li, Xiao-Nan, Meric-Bernstam, Funda, Meyer, Clifford A, Mou, Haiwei, Naegle, Kristen M, Pera, Martin F, Perova, Zinaida, Politi, Katerina A, Raphael, Benjamin J, Robson, Paul, Sears, Rosalie C, Tabernero, Josep, Tuveson, David A, Welm, Alana L, Welm, Bryan E, Willey, Christopher D, Salnikow, Konstantin, Chuang, Jeffrey H , Shen, Xiling (2022) A path to translation: How 3D patient tumor avatars enable next generation precision oncology. Cancer Cell,

Demyan, Lyudmyla, Habowski, Amber N, Plenker, Dennis, King, Daniel A, Standring, Oliver J, Tsang, Caitlin, St Surin, Luce, Rishi, Arvind, Crawford, James M, Boyd, Jeff, Pasha, Shamsher A, Patel, Hardik, Galluzzo, Zachary, Metz, Christine, Gregersen, Peter K, Fox, Sharon, Valente, Cristina, Abadali, Sonya, Matadial-Ragoo, Steffi, DePeralta, Danielle K, Deutsch, Gary B, Herman, Joseph M, Talamini, Mark A, Tuveson, David A , Weiss, Matthew J (2022) Pancreatic Cancer Patient-derived Organoids Can Predict Response to Neoadjuvant Chemotherapy. Annals of Surgery, 276(3) pp. 450-462.

Chung, Taemoon, Garcia, Libia, Swamynathan, Manojit M, Froeling, Fieke EM, Trotman, Lloyd C, Tuveson, David A , Lyons, Scott K (2022) Internally-controlled and dynamic optical measures of functional tumor biology. biorxiv,

Seppälä, Toni T, Zimmerman, Jacquelyn W, Suri, Reecha, Zlomke, Haley, Ivey, Gabriel D, Szabolcs, Annamaria, Shubert, Christopher R, Cameron, John L, Burns, William R, Lafaro, Kelly J, He, Jin, Wolfgang, Christopher L, Zou, Ying S, Zheng, Lei, Tuveson, David A, Eshlemann, James R, Ryan, David P, Kimmelman, Alec C, Hong, Theodore S, Ting, David T, Jaffee, Elizabeth M , Burkhart, Richard A (2022) Precision medicine in pancreatic cancer: Patient derived organoid pharmacotyping is a predictive biomarker of clinical treatment response. Clinical Cancer Research,

Kotani, Daisuke, Nakamura, Yoshiaki, Fujisawa, Takao, Bando, Hideaki, Sakamoto, Naoya, Johns, Amber L, Park, Keunchil, ICGC-ARGO, , Casolino, Raffaella, Yoshino, Takayuki , Biankin, Andrew V (2022) ICGC-ARGO precision medicine: targeted therapy according to longitudinal assessment of tumour heterogeneity in colorectal cancer.. The Lancet Oncology, 23(4) pp. 463-464.

Fernandez-Vega, Virneliz, Hou, Shurong, Plenker, Dennis, Tiriac, Hervé, Baillargeon, Pierre, Shumate, Justin, Scampavia, Louis, Seldin, Jan, Souza, Glauco R, Tuveson, David A , Spicer, Timothy P (2022) Lead Identification using 3D Models of Pancreatic Cancer: Development of 3D Tumor Models for High-throughput Screening.. Slas Discovery,

Bhatia, Sonam, Kramer, Melissa, Russo, Suzanne, Naik, Payal, Arun, Gayatri, Brophy, Kyle, Andrews, Peter, Fan, Cheng, Perou, Charles M, Preall, Jonathan, Ha, Taehoon, Plenker, Dennis, Tuveson, David A, Rishi, Arvind, Wilkinson, John E, McCombie, W Richard, Kostroff, Karen , Spector, David L (2022) Patient-derived triple-negative breast cancer organoids provide robust model systems that recapitulate tumor-intrinsic characteristics. Cancer Research,

Brennan, Christina M, Nadella, Sandeep, Zhao, Xiang, Dima, Richard J, Jordan-Martin, Nicole, Demestichas, Breanna R, Kleeman, Sam O, Ferrer, Miriam, von Gablenz, Eva Carlotta, Mourikis, Nicholas, Rubin, Michael E, Adnani, Harsha, Lee, Hassal, Ha, Taehoon, Prum, Soma, Schleicher, Cheryl B, Fox, Sharon S, Ryan, Michael G, Pili, Christina, Goldberg, Gary, Crawford, James M, Goodwin, Sara, Zhang, Xiaoyue, Preall, Jonathan B, Costa, Ana SH, Conigliaro, Joseph, Masci, Joseph R, Yang, Jie, Tuveson, David A, Tracey, Kevin J , Janowitz, Tobias (2022) Oral famotidine versus placebo in non-hospitalised patients with COVID-19: a randomised, double-blind, data-intense, phase 2 clinical trial. Gut,

Belleau, Pascal, Deschênes, Astrid, Tuveson, David , Krasnitz, Alexander (2022) Accurate and robust inference of genetic ancestry from cancer-derived molecular data across genomic platforms. BioRxiv,

De Sanctis, Francesco, Lamolinara, Alessia, Boschi, Federico, Musiu, Chiara, Caligola, Simone, Trovato, Rosalinda, Fiore, Alessandra, Frusteri, Cristina, Anselmi, Cristina, Poffe, Ornella, Cestari, Tiziana, Canè, Stefania, Sartoris, Silvia, Giugno, Rosalba, Del Rosario, Giulia, Zappacosta, Barbara, Del Pizzo, Francesco, Fassan, Matteo, Dugnani, Erica, Piemonti, Lorenzo, Bottani, Emanuela, Decimo, Ilaria, Paiella, Salvatore, Salvia, Roberto, Lawlor, Rita Teresa, Corbo, Vincenzo, Park, Youngkyu, Tuveson, David A, Bassi, Claudio, Scarpa, Aldo, Iezzi, Manuela, Ugel, Stefano , Bronte, Vincenzo (2022) Interrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer. Journal for ImmunoTherapy of Cancer, 10(1) pp. e003549-e003549.

Maiorino, Laura, Shevik, Margaret, Adrover, José M, Han, Xiao, Georgas, Elias, Wilkinson, John Erby, Seidner, Harrison, Foerschner, Leonie, Tuveson, David A, Qin, Yi-Xian , Egeblad, Mikala (2022) Longitudinal Intravital Imaging Through Clear Silicone Windows. Journal of Visualized Experiments, (179)

Milella, M, Luchini, C, Lawlor, RT, Johns, AL, Casolino, R, Yoshino, T, Biankin, AV, Stein, LD, Park, K, Korbel, JO, Zeps, N, Rubin, MA, Marra, MA, Elemento, O, Gallinger, S, Tuveson, D, Trumper, L, Koch, R, Scarpa, A, Brennan, P, Pilarsky, C, Nikolaev, S, Yoon, SS, Lee, ES, Shibata, T, Wu, X, Wu, J, Zhan, Q, Poon, W, Al-Kuraya, KS, Eeles, R, Fitzgerald, R, Caldas, C, Abraham, J , Chang, DK (2022) ICGC-ARGO precision medicine: familial matters in pancreatic cancer. The Lancet Oncology, 23(1) pp. 25-26.

Tonelli, Claudia, Deschênes, Astrid, Yao, Melissa, Park, Youngkyu , Tuveson, David (2022) Loss of p53 tumor suppression function drives invasion and genomic instability in models of murine pancreatic cancer. BioRxiv,

Hu, Tuo, Shukla, Surendra K, Vernucci, Enza, He, Chunbo, Wang, Dezhen, King, Ryan J, Jha, Kanupriya, Siddhanta, Kasturi, Mullen, Nicholas J, Attri, Kuldeep S, Murthy, Divya, Chaika, Nina V, Thakur, Ravi, Mulder, Scott E, Pacheco, Camila G, Fu, Xiao, High, Robin R, Yu, Fang, Lazenby, Audrey, Steegborn, Clemens, Lan, Ping, Mehla, Kamiya, Rotili, Dante, Chaudhary, Sarika, Valente, Sergio, Tafani, Marco, Mai, Antonello, Auwerx, Johan, Verdin, Eric, Tuveson, David , Singh, Pankaj K (2021) Metabolic Rewiring by Loss of Sirt5 Promotes Kras-induced Pancreatic Cancer Progression.. Gastroenterology,

Nielsen, Sebastian R, Strøbech, Jan E, Horton, Edward R, Jackstadt, Rene, Laitala, Anu, Bravo, Marina C, Maltese, Giorgia, Jensen, Adina RD, Reuten, Raphael, Rafaeva, Maria, Karim, Saadia A, Hwang, Chang-Il, Arnes, Luis, Tuveson, David A, Sansom, Owen J, Morton, Jennifer P , Erler, Janine T (2021) Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade. Nature Communications, 12(1) pp. 3414.

Cheng, Derek K, Oni, Tobiloba E, Thalappillil, Jennifer S, Park, Youngkyu, Ting, Hsiu-Chi, Alagesan, Brinda, Prasad, Nadia V, Addison, Kenneth, Rivera, Keith D, Pappin, Darryl J, Van Aelst, Linda , Tuveson, David A (2021) Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer.. Proceedings of the National Academy of Sciences of USA, 118(21) pp. e2016904118-e2016904118.

Steele, Nina G, Biffi, Giulia, Kemp, Samantha B, Zhang, Yaqing, Drouillard, Donovan, Syu, LiJyun, Hao, Yuan, Oni, Tobiloba E, Brosnan, Erin, Elyada, Ela, Doshi, Abhishek, Hansma, Christa, Espinoza, Carlos, Abbas, Ahmed, The, Stephanie, Irizarry-Negron, Valerie, Halbrook, Christopher J, Franks, Nicole E, Hoffman, Megan T, Brown, Kristee, Carpenter, Eileen S, Nwosu, Zeribe C, Johnson, Craig, Lima, Fatima, Anderson, Michelle A, Park, Youngkyu, Crawford, Howard C, Lyssiotis, Costas A, Frankel, Timothy L, Rao, Arvind, Bednar, Filip, Dlugosz, Andrzej A, Preall, Jonathan B, Tuveson, David A, Allen, Benjamin L , Pasca di Magliano, Marina (2021) Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer. Clinical Cancer Research, 27(7) pp. 2023-2037.

Tuveson, David A (2021) Fighting the Sixth Decade of the Cancer War with Better Cancer Models.. Cancer Discovery, 11(4) pp. 801-804.

Biffi, Giulia , Tuveson, David A (2021) Diversity and Biology of Cancer-Associated Fibroblasts.. Physiological Reviews, 101(1) pp. 147-176.

Gao, ChongFeng, Wisniewski, Luke, Liu, Ying, Staal, Ben, Beddows, Ian, Plenker, Dennis, Aldakkak, Mohammed, Hall, Johnathan, Barnett, Daniel, Gouda, Mirna Kheir, Allen, Peter, Drake, Richard, Zureikat, Amer, Huang, Ying, Evans, Douglas, Singhi, Aatur, Brand, Randall E, Tuveson, David A, Tsai, Susan , Haab, Brian B (2021) Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA. Clinical Cancer Research, 27(1) pp. 226-236.

Dreyer, Stephan B, Upstill-Goddard, Rosie, Paulus-Hock, Viola, Paris, Clara, Lampraki, Eirini-Maria, Dray, Eloise, Serrels, Bryan, Caligiuri, Giuseppina, Rebus, Selma, Plenker, Dennis, Galluzzo, Zachary, Brunton, Holly, Cunningham, Richard, Tesson, Mathias, Nourse, Craig, Bailey, Ulla-Maja, Jones, Marc, Moran-Jones, Kim, Wright, Derek W, Duthie, Fraser, Oien, Karin, Evers, Lisa, McKay, Colin J, McGregor, Grant A, Gulati, Aditi, Brough, Rachel, Bajrami, Ilirjana, Pettitt, Stephan, Dziubinski, Michele L, Candido, Juliana, Balkwill, Frances, Barry, Simon T, Grützmann, Robert, Rahib, Lola, Glasgow Precision Oncology Laboratory,, , Australian Pancreatic Cancer Genome Initiative, , Johns, Amber, Pajic, Marina, Froeling, Fieke EM, Beer, Phillip, Musgrove, Elizabeth A, Petersen, Gloria M, Ashworth, Alan, Frame, Margaret C, Crawford, Howard C, Simeone, Diane M, Lord, Chris, Mukhopadhyay, Debabrata, Pilarsky, Christian, Tuveson, David A, Cooke, Susanna L, Jamieson, Nigel B, Morton, Jennifer P, Sansom, Owen J, Bailey, Peter J, Biankin, Andrew V , Chang, David K (2021) Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer.. Gastroenterology, 160(1) pp. 362-377.e13.

Wan, Ledong, Lin, Kuan-Ting, Rahman, Mohammad Alinoor, Wang, Zhikai, Jensen, Mads, Park, Youngkyu, Tuveson, David , Krainer, Adrian (2021) Loss of KRAS G12D feedback regulation involving splicing factor SRSF1 accelerates pancreatic cancer. bioRxiv,

Zon, Leonard, Gomes, Ana P, Cance, William G, Ribas, Antoni, Tuveson, David, Postel-Vinay, Sophie, Massard, Christophe , Barlési, Fabrice (2020) Impact of COVID-19 Pandemic on Cancer Research.. Cancer Cell, 38(5) pp. 591-593.

Wong, Jasmine C, Perez-Mancera, Pedro A, Huang, Tannie Q, Kim, Jangkyung, Grego-Bessa, Joaquim, Del Pilar Alzamora, Maria, Kogan, Scott C, Sharir, Amnon, Keefe, Susan H, Morales, Carolina E, Schanze, Denny, Castel, Pau, Hirose, Kentaro, Huang, Guo N, Zenker, Martin, Sheppard, Dean, Klein, Ophir D, Tuveson, David A, Braun, Benjamin S , Shannon, Kevin (2020) KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.. JCI Insight, 5(21)

Casanova, Jean-Laurent, Holtzman, David M, Kaech, Susan M, Lanier, Lewis L, Nathan, Carl F, Rudensky, Alexander Y, Tuveson, David , Wolchok, Jedd D (2020) Immigration in science.. Journal of Experimental Medicine, 217(11)

Bradley, Sherille D, Talukder, Amjad H, Lai, Ivy, Davis, Rebecca, Alvarez, Hector, Tiriac, Herve, Zhang, Minying, Chiu, Yulun, Melendez, Brenda, Jackson, Kyle R, Katailiha, Arjun, Sonnemann, Heather M, Li, Fenge, Kang, Yaan, Qiao, Na, Pan, Bih-Fang, Lorenzi, Philip L, Hurd, Mark, Mittendorf, Elizabeth A, Peterson, Christine B, Javle, Milind, Bristow, Christopher, Kim, Michael, Tuveson, David A, Hawke, David, Kopetz, Scott, Wolff, Robert A, Hwu, Patrick, Maitra, Anirban, Roszik, Jason, Yee, Cassian , Lizée, Gregory (2020) Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers.. Nature Communications, 11(1) pp. 5332.

Vickman, Renee E, Faget, Douglas V, Beachy, Philip, Beebe, David, Bhowmick, Neil A, Cukierman, Edna, Deng, Wu-Min, Granneman, James G, Hildesheim, Jeffrey, Kalluri, Raghu, Lau, Ken S, Lengyel, Ernst, Lundeberg, Joakim, Moscat, Jorge, Nelson, Peter S, Pietras, Kristian, Politi, Katerina, Puré, Ellen, Scherz-Shouval, Ruth, Sherman, Mara H, Tuveson, David, Weeraratna, Ashani T, White, Richard M, Wong, Melissa H, Woodhouse, Elisa C, Zheng, Ying, Hayward, Simon W , Stewart, Sheila A (2020) Deconstructing tumor heterogeneity: the stromal perspective.. Oncotarget, 11(40) pp. 3621-3632.

Miyabayashi, Koji, Baker, Lindsey A, Deschênes, Astrid, Traub, Benno, Caligiuri, Giuseppina, Plenker, Dennis, Alagesan, Brinda, Belleau, Pascal, Li, Siran, Kendall, Jude, Jang, Gun Ho, Kawaguchi, Risa Karakida, Somerville, Tim DD, Tiriac, Hervé, Hwang, Chang-Il, Burkhart, Richard A, Roberts, Nicholas J, Wood, Laura D, Hruban, Ralph H, Gillis, Jesse, Krasnitz, Alexander, Vakoc, Christopher R, Wigler, Michael, Notta, Faiyaz, Gallinger, Steven, Park, Youngkyu , Tuveson, David A (2020) Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes.. Cancer Discovery, 10(10) pp. 1566-1589. American Association for Cancer Research (AACR).

Cheng, D. K., Oni, T. E., Park, Y., Thalappillil, J. S, Ting, H.-C., Alagesan, B., Prasad, N. V., Rivera, K. D., Pappin, D. J., Van Aelst, L. , Tuveson, D. A. (2020) Oncogenic KRAS engages an RSK1/NF1 complex in pancreatic cancer. BioRxiv,

Oni, Tobiloba E, Bautista, Carmelita, Merrill, Joseph R, Goos, Jeroen ACM, Rivera, Keith D, Miyabayashi, Koji, Biffi, Giulia, Garcia, Libia, Plenker, Dennis, Patel, Hardik, Elyada, Ela, Samaritano, Maria, Yu, Kenneth H, Pappin, Darryl J, Goggins, Michael G, Hruban, Ralph H, Lewis, Jason S, Lyons, Scott K, Yeh, Johannes T , Tuveson, David A (2020) Detection of incipient pancreatic cancer with novel tumor-specific antibodies in mouse models. BioRxiv,

Josselsohn, R. H. , Tuveson, D. A. (2020) Pancreatic cancer SLUGged. J Exp Med, 217(9)

Seppälä, Toni T, Zimmerman, Jacquelyn W, Sereni, Elisabetta, Plenker, Dennis, Suri, Reecha, Rozich, Noah, Blair, Alex, Thomas, Dwayne L, Teinor, Jonathan, Javed, Ammar, Patel, Hardik, Cameron, John L, Burns, William R, He, Jin, Tuveson, David A, Jaffee, Elizabeth M, Eshleman, James, Szabolcs, Annamaria, Ryan, David P, Ting, David T, Wolfgang, Christopher L , Burkhart, Richard A (2020) Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer.. Annals of Surgery, 272(3) pp. 427-435.

Lau, A. N., Li, Z., Danai, L. V., Westermark, A. M., Darnell, A. M., Ferreira, R., Gocheva, V., Sivanand, S., Lien, E. C., Sapp, K. M., Mayers, J. R., Biffi, G., Chin, C. R., Davidson, S. M., Tuveson, D. A., Jacks, T., Matheson, N. J., Yilmaz, O. , Vander Heiden, M. G. (2020) Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma. Elife, 9

Oni, T. E., Biffi, G., Baker, L. A., Hao, Y., Tonelli, C., Somerville, T. D. D., Deschênes, A., Belleau, P., Hwang, C. I., Sánchez-Rivera, F. J., Cox, H., Brosnan, E., Doshi, A., Lumia, R. P., Khaledi, K., Park, Y., Trotman, L. C., Lowe, S. W., Krasnitz, A., Vakoc, C. R. , Tuveson, D. A. (2020) SOAT1 promotes mevalonate pathway dependency in pancreatic cancer. J Exp Med, 217(9)

Dasgupta, A., Shukla, S.K., Vernucci, E., King, R.J., Abrego, J., Mulder, S.E., Mullen, N.J., Graves, G., Buettner, K., Thakur, R., Murthy, D., Attri, K.S., Wang, D., Chaika, N.V., Pacheco, C.G., Rai, I., Engle, D. D., Grandgenett, P. M., Punsoni, M., Reames, B.N., Teoh-Fitzgerald, M., Oberley-Deegan, R., Yu, F., Klute, K.A., Hollingsworth, M.A., Zimmerman, M.C., Mehla, K., Sadoshima, J., Tuveson, D. A. , Singh, P.K. (2020) SIRT1-NOX4 Signaling Axis Regulates Cancer Cachexia. J Exp Med, 217(7) pp. e20190745.

Janowitz, T., Gablenz, E., Pattinson, D., Wang, T.C., Conigliaro, J., Tracey, K. , Tuveson, D. (2020) Famotidine Use and Quantitative Symptom Tracking for COVID-19 in Non-Hospitalised Patients: A Case Series. Gut, 69(9) pp. 1592-1597.

AACR Board of Directors, (2020) AACR Calls on Congress to Take Immediate Action against COVID-19 and Protect Patients with Cancer during the Pandemic.. Cancer Discovery, 10(6) pp. 771-774.

Freedberg, D.E., Conigliaro, J., Wang, T.C., Tracey, K.J., Callahan, M.V., Abrams, J.A., On behalf of the Famotidine Research Group, Famotidine Research Group, Sobieszczyk, M.E., Markowitz, D.D., Gupta, A., O'Donnell, M.R., Li, J., Tuveson, D.A., Jin, Z., Turner, W.C. , Landry, D.W. (2020) Famotidine Use Is Associated With Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study. Gastroenterology,

Janowitz, T. , Tuveson, D. A. (2020) The Era of COVID-19 and the Rise of Science Collectivism in Cancer Research. Cancer Discov, 10(7) pp. 913-915.

Cheng, D. K. , Tuveson, D. A. (2020) Identifying protein interactors of oncogenic Kras in pancreatic cancer cells via proximity labelling.. Molecular Cancer Research, 18(5) pp. 64-64.

Chio, I. I. C., Oertlin, C., Robert, F., Chan, K., Liberm, D. K., Santana, A., Park, Y., Larsson, O., Pelletier, J. , Tuveson, D. A. (2020) Targeting redox dependencies in pancreatic cancer. Molecular Cancer Research, 18(5) pp. 22-22.

Tuveson, D. A. (2020) Pancreatic cancer models and medicine.. Molecular Cancer Research, 18(5) pp. 26-26.

Wong, J. C., Perez-Mancera, P. A., Kim, J., Jen, K. Y., Kogan, S. C., Firestone, A. J., Collisson, Eric A, Tuveson, D. A. , Shannon, K. (2020) A second site Kras(G12D) mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis.. Molecular Cancer Research, 18(5) pp. 43-43.

Corrie, P.G., Qian, W., Basu, B., Valle, J.W., Falk, S., Lwuji, C., Wasan, H., Palmer, D., Scott-Brown, M., Wadsley, J., Arif, S., Bridgewater, J., Propper, D., Gillmore, R., Gopinathan, A., Skells, R., Bundi, P., Brais, R., Dalchau, K., Bax, L., Chhabra, A., Machin, A., Dayim, A., McAdam, K., Cummins, S., Wall, L., Ellis, R., Anthoney, A., Evans, J., Ma, Y.T., Isherwood, C., Neesse, A., Tuveson, D. , Jodrell, D. I. (2020) Scheduling Nab-Paclitaxel Combined With Gemcitabine as First-Line Treatment for Metastatic Pancreatic Adenocarcinoma. Br J Cancer,

Somerville, T. D. D., Biffi, G., DaBler-Plenker, J., Hur, S.K., He, X.-Y., Vance, K.E., Miyabayashi, K., Xu, Y., Maia-Silva, D., Klingbeil, O., Demerdash, O. E., Preall, J. B., Hollingsworth, M. A., Egeblad, M., Tuveson, D. A. , Vakoc, C. R. (2020) Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. Elife, 9 pp. e53381.

Monje, M., Borniger, J., D'Silva, N.J., Deneen, B., Dirks, P.B., Fattahi, F., Frenette, P.S., Garzia, L., Gutmann, D.H., Hanahan, D., Hervey-Jumper, S.L., Hondermarck, H., Hurov, J.B., Kepecs, A., Knox, S.M., Lloyd, A.C., Magnon, C., Saloman, J.L., Segal, R.A., Sloan, E.K., Sun, X., Taylor, M.D., Tracey, K.J., Trotman, L. C., Tuveson, D. A., Wang, T.C., White, R.A. , Winkler, F. (2020) Roadmap for the Emerging Field of Cancer Neuroscience. Cell, 181(2) pp. 219-222.

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., Hynes, R. O., Jain, R. K., Janowitz, T., Jorgensen, C., Kimmelman, A. C., Kolonin, M. G., Maki, R. G., Powers, R. S., Pure, E., Ramirez, D. C., Scherz-Shouval, R., Sherman, M. H., Stewart, S., Tlsty, T. D., Tuveson, D. A., Watt, F. M., Weaver, V., Weeraratna, A. T. , Werb, Z. (2020) A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer, 20(3) pp. 174-186.

LaComb, J. F., Plenker, D., Tiriac, H., Bucobo, J. C., D'Souza, L.S., Khokhar, A.S., Patel, H., Channer, B., Joseph, D., Wu, M., Tuveson, D. A., Li, E. , Buscaglia, J. M. (2020) Single-Pass vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation of Pancreatic Adenocarcinoma Organoids. Clin Gastroenterol Hepatol,

Moral, J.A., Leung, J., Rojas, L.A., Ruan, J., Zhao, J., Sethna, Z., Ramnarain, A., Gasmi, B., Gururajan, M., Redmond, D., Askan, G., Bhanot, U., Elyada, E., Park, Y., Tuveson, D. A., Gonen, M., Leach, S.D., Wolchok, J.D., DeMatteo, R. P., Merghoub, T. , Balachandran, V. P. (2020) ILC2s Amplify PD-1 Blockade by Activating Tissue-Specific Cancer Immunity. Nature, 579(7797) pp. 130-135.

Tian, C., Ohlund, D., Rickelt, S., Lidstrom, T., Huang, Y., Hao, L., Zhao, R. T., Franklin, O., Bhatia, S. N., Tuveson, D. A. , Hynes, R. O. (2020) Cancer-cell-derived matrisome proteins promote metastasis in pancreatic ductal adenocarcinoma. Cancer Res, 80(7) pp. 1461-1474.

Perez, K, Cleary, J. M., Karasic, T. B., Raghaven, S., Rahma, O. E., Nowak, J. A., Borazanci, E. H., Downes, Michael, Drebin, Jeffrey A, Tuveson, D. A., Ting, D. T., Moffitt, R. A., Yeh, J. J., Aguirre, A. J., Evans, R., Von Hoff, D. D., Odwyer, P. J. , Wolpin, B. M. (2020) Vitamin D receptor agonist paricalcitol plus gemcitabine and nab-paclitaxel in patients with metastatic pancreatic cancer. Journal of Clinical Oncology, 38(4)

Noble, Karen, Owens, Joanna, Andre, Fabrice, Bakhoum, Samuel F, Loi, Sherene, Reinhardt, Hans Christian, Tuveson, David , Swanton, Charles (2020) Securing the future of the clinician-scientist. Nature Cancer, 1(2) pp. 139-141.

Chan-Seng-Yue, M., Kim, J. C., Wilson, G. W., Ng, K., Figueroa, E. F., O'Kane, G. M., Connor, A. A., Denroche, R. E., Grant, R. C., McLeod, J., Wilson, J. M., Jang, G. H., Zhang, A., Liang, S. B., Borgida, A., Chadwick, D., Kalimuthu, S., Lungu, I., Bartlett, J. M. S., Krzyzanowski, P. M., Sandhu, V., Tiriac, H., Froeling, F. E. M., Karasinska, J. M., Topham, J. T., Renouf, D. J., Schaeffer, D. F., Jones, S. J. M., Marra, M. A., Laskin, J., Chetty, R., Stein, L. D., Zogopoulos, G., Haibe-Kains, B., Campbell, P. J., Tuveson, D. A., Knox, J. J., Fischer, S. E., Gallinger, S. , Notta, F. (2020) Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution. Nat Genet,

Cheung, E. C., DeNicola, G. M., Nixon, C., Blyth, K., Labuschagne, C. F., Tuveson, D. A. , Vousden, K. H. (2020) Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer. Cancer Cell,

Bott, A. J., Shen, J., Tonelli, C., Zhan, L., Sivaram, N., Jiang, Y. P., Yu, X., Bhatt, V., Chiles, E., Zhong, H., Maimouni, S., Dai, W., Velasquez, S., Pan, J. A., Muthalagu, N., Morton, J., Anthony, T. G., Feng, H., Lamers, W. H., Murphy, D. J., Guo, J. Y., Jin, J., Crawford, H. C., Zhang, L., White, E., Lin, R. Z., Su, X., Tuveson, D. A. , Zong, W. X. (2019) Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell Rep, 29(5) pp. 1287-1298.e6.

Froeling, F. E. M., Mosur Swamynathan, M., Deschenes, A., Chio, I. I. C., Brosnan, E., Yao, M. A., Alagesan, P., Lucito, M. S., Li, J., Chang, A. Y., Trotman, L. C., Belleau, P., Park, Y., Rogoff, H. A., Watson, J. D. , Tuveson, D. A. (2019) Bioactivation of napabucasin triggers reactive oxygen species-mediated cancer cell death. Clin Cancer Res, 25(23) pp. 7162-7174.

Ponz-Sarvise, M., Corbo, V., Tiriac, H., Engle, D. D., Frese, K. K., Oni, T. E., Hwang, C. I., Ohlund, D., Chio, I. I. C., Baker, L. A., Filippini, D., Wright, K., Bapiro, T. E., Huang, P. S., Smith, P. D., Yu, K. H., Jodrell, D. I., Park, Y. , Tuveson, D. A. (2019) Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer. Clin Cancer Res, 25(22) pp. 6742-6755.

Tian, C., Clauser, K. R., Ohlund, D., Rickelt, S., Huang, Y., Gupta, M., Mani, D. R., Carr, S. A., Tuveson, D. A. , Hynes, R. O. (2019) Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells. Proc Natl Acad Sci U S A, 116(39) pp. 19609-19618.

Mirabelli, C. K., Nusse, R., Tuveson, D. A. , Williams, B. O. (2019) Perspectives on the role of Wnt biology in cancer. Sci Signal, 12(589)

Sugarman, R., Patel, R., Sharma, S., Plenker, D., Tuveson, D. , Saif, M. W. (2019) Pharmacokinetics and pharmacodynamics of new drugs for pancreatic cancer. Expert Opin Drug Metab Toxicol, 15(7) pp. 541-552.

Humpton, T. J., Alagesan, B., DeNicola, G. M., Lu, D., Yordanov, G. N., Leonhardt, C. S., Yao, M. A., Alagesan, P., Zaatari, M. N., Park, Y., Skepper, J. N., Macleod, K. F., Perez-Mancera, P. A., Murphy, M. P., Evan, G. I., Vousden, K. H. , Tuveson, D. A. (2019) Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer. Cancer Discov, 99(9) pp. 1268-1298.

Froeling, F. E., Robine, N., Hubert, B., Zody, M., Oschwald, D., Varmus, H. E., Sawyers, C. L., Tuveson, D. A. , Consortium, Nygc P. (2019) Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York. Cancer Research, 79(13S) pp. Meeting Abstract: 5128 .

Dent, P., Booth, L., Roberts, J. L., Liu, J., Poklepovic, A., Lalani, A. S., Tuveson, D., Martinez, J. , Hancock, J. F. (2019) Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells. Oncogene,

Engle, D. D., Tiriac, H., Rivera, K. D., Pommier, A., Whalen, S., Oni, T. E., Alagesan, B., Lee, E. J., Yao, M. A., Lucito, M. S., Spielman, B., Da Silva, B., Schoepfer, C., Wright, K., Creighton, B., Afinowicz, L., Yu, K. H., Grutzmann, R., Aust, D., Gimotty, P. A., Pollard, K. S., Hruban, R. H., Goggins, M. G., Pilarsky, C., Park, Y., Pappin, D. J., Hollingsworth, M. A. , Tuveson, D. A. (2019) The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice. Science, 364(6446) pp. 1156-1162.

Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., Sivajothi, S., Armstrong, T. D., Engle, D. D., Yu, K. H., Hao, Y., Wolfgang, C. L., Park, Y., Preall, J., Jaffee, E. M., Califano, A., Robson, P. , Tuveson, D. A. (2019) Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. Cancer Discov, 9(8) pp. 1102-1123.

Tuveson, D. , Clevers, H. (2019) Cancer modeling meets human organoid technology. Science, 364(6444) pp. 952-955.

Driehuis, E., Kolders, S., Spelier, S., Lohmussaar, K., Willems, S. M., Devriese, L. A., de Bree, R., de Ruiter, E. J., Korving, J., Begthel, H., Van Es, J. H., Geurts, V., He, G. W., van Jaarsveld, R. H., Oka, R., Muraro, M. J., Vivie, J., Zandvliet, Mmjm, Hendrickx, A. P. A., Iakobachvili, N., Sridevi, P., Kranenburg, O., van Boxtel, R., Kops, Gjpl, Tuveson, D. A., Peters, P. J., van Oudenaarden, A. , Clevers, H. (2019) Oral mucosal organoids as a potential platform for personalized cancer therapy. Cancer Discov, 9(7) pp. 852-871.

Biffi, G. , Tuveson, D. A. (2019) A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth. Cancer Discov, 9(5) pp. 578-580.

Tiriac, H., Plenker, D., Baker, L. A. , Tuveson, D. A. (2019) Organoid models for translational pancreatic cancer research. Curr Opin Genet Dev, 54 pp. 7-11.

Baker, L. A., Tiriac, H. , Tuveson, D. A. (2019) Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens. Methods Mol Biol, 1882 pp. 97-115.

Baker, L. A. , Tuveson, D. A. (2019) Generation and Culture of Tumor and Metastatic Organoids from Murine Models of Pancreatic Ductal Adenocarcinoma. Methods Mol Biol, 1882 pp. 117-133.

Somerville, Tim DD, Biffi, Giulia, Daßler-Plenker, Juliane, Miyabayashi, Koji, Xu, Yali, Maia-Silva, Diogo, Klingbeil, Olaf, Demerdash, Osama, Egeblad, Mikala, Tuveson, David , Vakoc, Christopher (2019) Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. eLife,

Biffi, G. , Tuveson, D. A. (2018) Deciphering cancer fibroblasts. J Exp Med,

Somerville, T. D. D., Xu, Y., Miyabayashi, K., Tiriac, H., Cleary, C. R., Maia-Silva, D., Milazzo, J. P., Tuveson, D. A. , Vakoc, C. R. (2018) TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Cell Rep, 25(7) pp. 1741-1755.e7.

Biffi, G., Oni, T. E., Spielman, B., Hao, Y., Elyada, E., Park, Y., Preall, J. , Tuveson, D. A. (2018) IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma. Cancer Discov, 9(2) pp. 282-301.

Neesse, A., Bauer, C. A., Ohlund, D., Lauth, M., Buchholz, M., Michl, P., Tuveson, D. A. , Gress, T. M. (2018) Stromal biology and therapy in pancreatic cancer: ready for clinical translation?. Gut, 68(1) pp. 159-171.

Hou, Shurong, Tiriac, Hervé, Sridharan, Banu Priya, Scampavia, Louis, Madoux, Franck, Seldin, Jan, Souza, Glauco R, Watson, Donald, Tuveson, David , Spicer, Timothy P (2018) Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening.. Slas Discovery, 23(6) pp. 574-584.

Munoz-Sagastibelza, M., Tiriac, H., Vignesh, S., Sanchez, J. P., Somma, J., Li, E., Bucobo, J. C., Tzimas, D. J., Wu, M., Martello-Rooney, L., Tuveson, D. , Buscaglia, J. (2018) Living biobank of endoscopic ultrasound guided fine needle biopsy-derived PDAC organoids: A study of two contrasting populations. Cancer Epidemiology Biomarkers & Prevention, 27(7 Supp) pp. 95-95.

Aguirre, A. J., Nowak, J. A., Camarda, N. D., Moffitt, R. A., Ghazani, A. A., Hazar-Rethinam, M., Raghavan, S., Kim, J., Brais, L. K., Ragon, D., Welch, M. W., Reilly, E., McCabe, D., Marini, L., Anderka, K., Helvie, K., Oliver, N., Babic, A., Da Silva, A., Nadres, B., Van Seventer, E. E., Shahzade, H. A., St Pierre, J. P., Burke, K. P., Clancy, T. E., Cleary, J. M., Doyle, L. A., Jajoo, K., McCleary, N. J., Meyerhardt, J. A., Murphy, J. E., Ng, K., Patel, A. K., Perez, K., Rosenthal, M. H., Rubinson, D. A., Ryou, M., Shapiro, G. I., Sicinska, E., Silverman, S. G., Nagy, R. J., Lanman, R. B., Knoerzer, D., Welsch, D. J., Yurgelun, M. B., Fuchs, C. S., Garraway, L. A., Getz, G., Hornick, J. L., Johnson, B. E., Kulke, M. H., Mayer, R. J., Miller, J. W., Shyn, P. B., Tuveson, D. A., Wagle, N., Yeh, J. J., Hahn, W. C., Corcoran, R. B., Carter, S. L. , Wolpin, B. M. (2018) Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine. Cancer Discov, 8(9) pp. 1096-1111.

Tiriac, H., Bucobo, J. C., Tzimas, D., Grewel, S., Lacomb, J. F., Rowehl, L. M., Nagula, S., Wu, M., Kim, J., Sasson, A., Vignesh, S., Martello, L., Munoz-Sagastibelza, M., Somma, J., Tuveson, D. A., Li, E. , Buscaglia, J. M. (2018) Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment. Gastrointest Endosc, 87(6) pp. 1474-1480.

Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschenes, A., Somerville, T., Froeling, F. E. M., Burkhart, R. A., Denroche, R. E., Jang, G. H., Miyabayashi, K., Young, C. M., Patel, H., Ma, M., LaComb, J. F., Palmaira, R. L. D., Javed, A. A., Huynh, J. A., Johnson, M., Arora, K., Robine, N., Shah, M., Sanghvi, R., Goetz, A. B., Lowder, C. Y., Martello, L., Driehuis, E., Lecomte, N., Askan, G., Iacobuzio-Donahue, C. A., Clevers, H., Wood, L. D., Hruban, R. H., Thompson, E. D., Aguirre, A. J., Wolpin, B. M., Sasson, A., Kim, J., Wu, M., Bucobo, J. C., Allen, P. J., Sejpal, D. V., Nealon, W., Sullivan, J. D., Winter, J. M., Gimotty, P. A., Grem, J. L., DiMaio, D. J., Buscaglia, J. M., Grandgenett, P. M., Brody, J. R., Hollingsworth, M. A., O'Kane, G. M., Notta, F., Kim, E. J., Crawford, J. M., Devoe, C. E., Ocean, A., Wolfgang, C. L., Yu, K. H., Li, E., Vakoc, C. R., Hubert, B., Fischer, S. E., Wilson, J. M., Moffitt, R. A., Knox, J. J., Krasnitz, A., Gallinger, S. , Tuveson, D. A. (2018) Organoid profiling identifies common responders to chemotherapy in pancreatic cancer. Cancer Discovery, 8(9) pp. 1112-1129.

Quaranta, V., Rainer, C., Nielsen, S. R., Raymant, M. L., Ahmed, M. S., Engle, D. D., Taylor, A., Murray, T., Campbell, F., Palmer, D. H., Tuveson, D. A. , Mielgo, A. (2018) Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer. Cancer Res, 78(15) pp. 4253-4269.

Engle, D., Tiriac, H., Pommier, A., Schoepfer, C., Da Silva, B., Yao, M., Park, Y., Hollingsworth, M. A. , Tuveson, D. (2018) Exploring the role of glycosylation in pancreatic diseass. Cancer Research, 78(10 Sup) pp. 44-44.

Froeling, F. , Tuveson, D. (2018) Pancreatic cancer foiled by a switch of tumour subtype. Nature, 557(7706) pp. 500-501.

Tiriac, H., Burkhart, R. A., Belleau, P., Young, M. C., Ma, M., Engle, D. D., Li, E., Yu, K. H. , Tuveson, D. A. (2018) Pharmacotyping patients using pancreatic cancer organoids. Cancer Research, 78(10, Su)

Tuveson, D., Engle, D., Hwang, C., Vakoc, C. , Roe, J. S. (2018) GEMMs and GEOs to characterize pancreatic cancer initiation and progression. Cancer Research,

Cook, N., Basu, B., Smith, D. M., Gopinathan, A., Evans, J., Steward, W. P., Palmer, D., Propper, D., Venugopal, B., Hategan, M., Anthoney, D. A., Hampson, L. V., Nebozhyn, M., Tuveson, D., Farmer-Hall, H., Turner, H., McLeod, R., Halford, S. , Jodrell, D. (2018) A phase I trial of the gamma-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma. Br J Cancer, 118(6) pp. 793-801.

Wolff, R. A., Wang-Gillam, A., Alvarez, H., Tiriac, H., Engle, D., Hou, S., Groff, A. F., Lucas, A. S., Bernard, V., Allenson, K., Castillo, J., Kim, D., Mulu, F., Huang, J., Stephens, B., Wistuba, I. I., Katz, M., Varadhachary, G., Park, Y., Hicks, J., Chinnaiyan, A., Scampavia, L., Spicer, T., Gerhardinger, C., Maitra, A., Tuveson, D., Rinn, J., Lizee, G., Yee, C. , Levine, A. J. (2018) Dynamic changes during the treatment of pancreatic cancer. Oncotarget, 9(19) pp. 14764-14790.

Cheng, D. , Tuveson, D. (2018) Kras in Organoids. Cold Spring Harb Perspect Med, 8(10)

Aberle, M. R., Burkhart, R. A., Tiriac, H., Olde Damink, S. W. M., Dejong, C. H. C., Tuveson, D. A. , van Dam, R. M. (2018) Patient-derived organoid models help define personalized management of gastrointestinal cancer. Br J Surg, 105(2) pp. e48-e60.

Vakoc, C. R. , Tuveson, D. A. (2017) Soils and Seeds That Initiate Pancreatic Cancer Metastasis. Cancer Discov, 7(10) pp. 1067-1068.

Tonelli, C., Chio, I. I. C. , Tuveson, D. A. (2017) Transcriptional regulation by Nrf2. Antioxid Redox Signal,

Corrie, P., Qian, W., Gopinathan, A., Williams, M., Brais, R., Valle, J. W., Basu, B., Falk, S., Iwuji, C., Wasan, H., Palmer, D., Scott-Brown, M., Wadsley, J., Arif, S., Bax, L., Bundi, P., Skells, R., Neesse, A., Tuveson, D. , Jodrell, D. (2017) Strong tumour cytidine deaminase (CDA) staining predicts for improved survival associated with sequential nab-Paclitaxel (nabP) and gemcitabine (GEM) chemotherapy as first line treatment of patients (pts) with metastatic pancreatic adenocarcinoma (mPDAC). Annals of Oncology, 28(Supple) pp. 73P.

Roe, J. S., Hwang, C. I., Somerville, T. D. D., Milazzo, J. P., Lee, E. J., Da Silva, B., Maiorino, L., Tiriac, H., Young, C. M., Miyabayashi, K., Filippini, D., Creighton, B., Burkhart, R. A., Buscaglia, J. M., Kim, E. J., Grem, J. L., Lazenby, A. J., Grunkemeyer, J. A., Hollingsworth, M. A., Grandgenett, P. M., Egeblad, M., Park, Y., Tuveson, D. A. , Vakoc, C. R. (2017) Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell, 170(5) pp. 875-888.

Feigin, M. E., Garvin, T., Bailey, P., Waddell, N., Chang, D. K., Kelley, D. R., Shuai, S., Gallinger, S., McPherson, J. D., Grimmond, S. M., Khurana, E., Stein, L. D., Biankin, A. V., Schatz, M. C. , Tuveson, D. A. (2017) Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma. Nat Genet, 49(6) pp. 825-833.

Buscaglia, Jonathan M., Bucobo, Juan Carlos, Tiriac, Herve, Tzimas, Demetrios, Grewal, Suman, LaComb, Joseph, Rowehl, Leahana, Nagula, Satish, Wu, Maoxin, Kim, Joseph, Sasson, Aaron, Li, Ellen, Young, Candice M. , Tuveson, David A. (2017) 111 Successful Creation of Pancreatic Cancer Organoids By Means of Eus-Guided Fine-Needle Biopsy (EUS-FNB) for Personalized Cancer Treatment. Gastrointestinal Endoscopy, 85(5, Sup) pp. AB50-AB51.

Chio, Iok In Christine , Tuveson, David A. (2017) ROS in Cancer: The Burning Question. Trends in Molecular Medicine, 23(5) pp. 411-429.

Sacristán, Catarina , Tuveson, David A (2017) Quid pro Quo: A Tumor is Not Alone.. Trends in Molecular Medicine, 23(5) pp. 375-376.

Sinha, S., Fu, Y. Y., Grimont, A., Ketcham, M., Lafaro, K. J., Saglimbeni, J. A., Askan, G., Bailey, J. M., Melchor, J. P., Zhong, Y., Joo, M. G., Grbovic-Huezo, O., Yang, I. H., Basturk, O., Baker, L., Park, Y., Kurtz, R. C., Tuveson, D. A., Leach, S. D. , Pasricha, P. (2017) PanIN neuroendocrine cells promote tumorigenesis via neuronal crosstalk. Cancer Res, 77(8) pp. 1868-1879.

Tuveson, D. (2017) Waging war against pancreatic cancer: an interview with David Tuveson. Dis Model Mech, 10(4) pp. 353-357.

Feigin, M. E. , Tuveson, D. A. (2017) Organoid models to interrogate GPCR regulation of pancreatic tumorigenesis. Faseb Journal, 31(Supple) pp. Meeting Abstract: lb524 .

Ohlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., Chio, II, Hwang, C. I., Tiriac, H., Baker, L. A., Engle, D. D., Feig, C., Kultti, A., Egeblad, M., Fearon, D. T., Crawford, J. M., Clevers, H., Park, Y. , Tuveson, D. A. (2017) Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med, 214(3) pp. 579-596.

Chio, I. I. C., Jafarnejad, S. M., Ponz-Sarvise, M., Park, Y., Rivera, K., Palm, W., Ohlund, D., Hammell, M., Crawford, H., Schmidt, E., Thompson, C., Pappin, D., Sonenberg, N. , Tuveson, D. (2017) NRF2 promotes tumor maintenance by modulating mRNA translation in pancreatic cancer. Cancer Research, 77(Supple)

Vakoc, C. R. , Tuveson, D. A. (2017) Untangling the genetics from the epigenetics in pancreatic cancer metastasis. Nat Genet, 49(3) pp. 323-324.

Senturk, S., Shirole, N. H., Nowak, D. G., Corbo, V., Pal, D., Vaughan, A., Tuveson, D. A., Trotman, L. C., Kinney, J. B. , Sordella, R. (2017) Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization. Nat Commun, 8 pp. 14370.

Biffi, G. , Tuveson, D. A. (2017) Cancer: Double trouble for tumours. Nature, 542(7639) pp. 34-35.

Chio, II , Tuveson, D. A. (2017) ROS in translation: Chink in the armor. Cell Cycle, 16(4) pp. 297-298.

Ireland, L., Santos, A., Ahmed, M. S., Rainer, C., Nielsen, S. R., Quaranta, V., Weyer-Czernilofsky, U., Engle, D. D., Perez-Mancera, P., Coupland, S. E., Taktak, A. F., Bogenrieder, T., Tuveson, D. A., Campbell, F., Schmid, M. C. , Mielgo, A. (2016) Chemoresistance in pancreatic cancer is driven by stroma-derived insulin-like growth factors. Cancer Res, 76(23) pp. 6851-6863.

Tuveson, D. A. (2016) Detecting and killing pancreatic cancer. Human Gene Therapy, 27(11) pp. A12-A12.

Chio, Iok In Christine, Jafarnejad, Seyed Mehdi, Ponz-Sarvise, Mariano, Park, Youngkyu, Rivera, Keith, Palm, Wilhelm, Wilson, John, Sangar, Vineet, Hao, Yuan, Öhlund, Daniel, Wright, Kevin, Filippini, Dea, Lee, Eun Jung, Da Silva, Brandon, Schoepfer, Christina, Wilkinson, John Erby, Buscaglia, Jonathan M, DeNicola, Gina M, Tiriac, Herve, Hammell, Molly, Crawford, Howard C, Schmidt, Edward E, Thompson, Craig B, Pappin, Darryl J, Sonenberg, Nahum , Tuveson, David A (2016) NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell, 166(4) pp. 963-976.

Biffi, G., Ohlund, D. , Tuveson, D. (2016) Building up the tension between the epithelial and stromal compartment in pancreatic ductal adenocarcinoma. Cell Death Differ, 23(8) pp. 1265-1266.

Ohman, K. A., Hashim, Y. M., Vangveravong, S., Nywening, T. M., Cullinan, D. R., Goedegebuure, S. P., Liu, J., Van Tine, B. A., Tiriac, H., Tuveson, D. A., DeNardo, D. G., Spitzer, D., Mach, R. H. , Hawkins, W. G. (2016) Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic. Oncotarget, 7(23) pp. 33529-33541.

Öhlund, Daniel, Handly-Santana, Abram, Elyada, Ela, Biffi, Giulia , Tuveson, David A. (2016) Pancreatic stellate cell heterogeneity in cancer. Pancreatology, 16(3, Sup) pp. S15.

Kleeff, J., Korc, M., Apte, M., La Vecchia, C., Johnson, C. D., Biankin, A. V., Neale, R. E., Tempero, M., Tuveson, D. A., Hruban, R. H. , Neoptolemos, J. P. (2016) Pancreatic cancer. Nat Rev Dis Primers, 2 pp. 16022.

Nielsen, S. R., Quaranta, V., Linford, A., Emeagi, P., Rainer, C., Santos, A., Ireland, L., Sakai, T., Sakai, K., Kim, Y. S., Engle, D., Campbell, F., Palmer, D., Ko, J. H., Tuveson, D. A., Hirsch, E., Mielgo, A. , Schmid, M. C. (2016) Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nat Cell Biol, 18(5) pp. 549-60.

Baker, Lindsey A., Tiriac, Hervé, Clevers, Hans , Tuveson, David A. (2016) Modeling Pancreatic Cancer with Organoids. Trends in Cancer, 2(4) pp. 176-190.

Jenkinson, C., Elliott, V., Evans, A., Oldfield, L., Jenkins, R. E., O'Brien, D. P., Apostolidou, S., Gentry-Maharaj, A., Fourkala, E. O., Jacobs, I., Menon, U., Cox, T. F., Campbell, F., Pereira, S. P., Tuveson, D. A., Park, P. K., Greenhalf, W., Sutton, R. Professor, Timms, J. F., Neoptolemos, J. , Costello, E. (2016) Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus. Clin Cancer Res, 22(7) pp. 1734-43.

Serrao, E. M., Kettunen, M. I., Rodrigues, T. B., Dzien, P., Wright, A. J., Gopinathan, A., Gallagher, F. A., Lewis, D. Y., Frese, K. K., Almeida, J., Howat, W. J., Tuveson, D. A. , Brindle, K. M. (2016) MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model. Gut, 65(3) pp. 465-75.

Espana-Agusti, J., Zou, X. G., Wong, K., Fu, B. Y., Yang, F. T., Tuveson, D. A., Adams, D. J. , Matakidou, A. (2016) Generation and Characterisation of a Pax8-CreER(T2) Transgenic Line and a Slc22a6-CreER(T2) Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells. Plos One, 11(2)

Boj, S. F., Hwang, C. I., Baker, L. A., Engle, D. D., Tuveson, D. A. , Clevers, H. (2016) Model organoids provide new research opportunities for ductal pancreatic cancer. Mol Cell Oncol, 3(1) pp. e1014757.

Hwang, C. I., Boj, S. F., Clevers, H. , Tuveson, D. A. (2016) Pre-clinical Models of Pancreatic Ductal Adenocarcinoma. J Pathol, 238(2) pp. 197-204.

Feigin, M. E. , Tuveson, D. A. (2016) Challenges and Opportunities in Modeling Pancreatic Cancer. Cold Spring Harb Symp Quant Biol, 81 pp. 231-235.

Rosati, A., Basile, A., D'Auria, R., d'Avenia, M., De Marco, M., Falco, A., Festa, M., Guerriero, L., Iorio, V., Parente, R., Pascale, M., Marzullo, L., Franco, R., Arra, C., Barbieri, A., Rea, D., Menichini, G., Hahne, M., Bijlsma, M., Barcaroli, D., Sala, G., di Mola, F. F., di Sebastiano, P., Todoric, J., Antonucci, L., Corvest, V., Jawhari, A., Firpo, M. A., Tuveson, D. A., Capunzo, M., Karin, M., De Laurenzi, V. , Turco, M. C. (2015) BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nat Commun, 6 pp. 8695.

Jenkinson, C., Elliott, V. L., Evans, A., Oldfield, L., Timms, J. F., Gentry-Maharaj, A., Menon, U., Cox, T., Campbell, F., Sutton, R., Pereira, S. P., Tuveson, D. A., Greenhalf, W., Neoptolemos, J. P. , Costello, E. (2015) Decreased Serum Thrombospondin-1 Levels in Pancreatic Ductal Adenocarcinoma Patients: An Early Indicator of Cancer or Diabetes Development?. Pancreas, 44(8) pp. 1383-1383.

Zambirinis, C. P., Levie, E., Nguy, S., Avanzi, A., Barilla, R., Xu, Y., Seifert, L., Daley, D., Greco, S. H., Deutsch, M., Jonnadula, S., Torres-Hernandez, A., Tippens, D., Pushalkar, S., Eisenthal, A., Saxena, D., Ahn, J., Hajdu, C., Engle, D. D., Tuveson, D. , Miller, G. (2015) TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. J Exp Med,

Neesse, A., Algul, H., Tuveson, D. A. , Gress, T. M. (2015) Stromal biology and therapy in pancreatic cancer: a changing paradigm. Gut, 64(9) pp. 1476-1484.

Rosati, A., Basile, A., D'Auria, R., d'Avenia, M., De Marco, M., Falco, A., Festa, M., Guerriero, L., Iorio, V., Pascale, M., Franco, R., Arra, C., Barbieri, A., Rea, D., Menichini, G., Hahne, M., Bijlsma, M., Barcaroli, D., Tuveson, D. A., Todoric, J., Karin, M., De Laurenzi, V. , Turco, M. C. (2015) PDAC cells release BAG3 that activates a paracrine loop with stromal macrophages. Cancer Research, 75(Supple) pp. Abstract 2393.

Ponz-Sarvise, Mariano, Tuveson, David A. , Yu, Kenneth H. (2015) Mouse Models of Pancreatic Ductal Adenocarcinoma. Hematology/Oncology Clinics of North America, 29(4) pp. 609-617.

Tian, C. X., Ohlund, D., Clauser, K., Carr, S. A., Tuveson, D. A. , Hynes, R. O. (2015) Profiling of extracellular matrix proteins in pancreatic ductal adenocarcinoma progression and metastasis. Cancer Research, 75(Supple)

Palm, W., Park, Y., Wright, K., Pavlova, N. N., Tuveson, D. A. , Thompson, C. B. (2015) The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1. Cell, 162(2) pp. 259-270.

Carapua, E. F., Gemenetzidis, E., Feig, C., Tuveson, D. , Kocher, H. (2015) Developing drug combinations to co-target pancreatic cancer and its supporting stroma. Cancer Research, 75(Supple) pp. B72.

Roy, I., McAllister, D., Gorse, E., Dixon, K., Cheng, G., Getschman, A., Engle, D., Tsai, S., Tuveson, D., Evans, D., Volkman, B., Kalyanaraman, B. , Dwinell, M. (2015) Chemokine biased agonists regulate pancreatic cancer migration and metastasis through bioenergetic signaling. Cancer Research, 75(Supple) pp. B55.

Tian, C. X., Olund, D., Tuveson, D. , Hynes, R. O. (2015) Understanding the roles of extracellular matrix proteins in pancreatic ductal adenocarcinoma progression and metastasis. Cancer Research, 75(Supple) pp. A45.

Espana-Agusti, J., Tuveson, D. A., Adams, D. J. , Matakidou, A. (2015) A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep, 5 pp. 11061.

Tuveson, D. , Rai, K. R. (2015) Augmenting NF-kappaB in poor-risk CLL: A general paradigm for other cancers?. J Exp Med, 212(6) pp. 830-1.

Jenkinson, Claire, Elliott, Victoria, Evans, Anthony, Oldfield, Lucy, O'Brien, Darragh, Apostolidou, Sophia, Gentry-Maharaj, Aleksandra, Fourkala, Evangelia- O., Jacobs, Ian, Menon, Usha, Cox, Trevor, Campbell, Fiona, Tuveson, David, Greenhalf, William, Sutton, Robert, Pereira, Stephen, Timms, John, Neoptolemos, John , Costello, Eithne (2015) Decreased serum thrombospondin-1 levels in pancreatic ductal adenocarcinoma patients: an early indicator of disease or diabetes mellitus development?. Pancreatology, 15(3, Sup) pp. S28.

Saiyin, H., Ardito-Abraham, C. M., Wu, Y., Wei, Y., Fang, Y., Han, X., Li, J., Zhou, P., Yi, Q., Maitra, A., Liu, J. O., Tuveson, D. A., Lou, W. , Yu, L. (2015) Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma. J Pathol, 236(2) pp. 142-154.

Tournier, Cathy, Davies, Clare C., Harvey, Emma, McMahon, Raymond F. T., Finegan, Katherine G., Connor, Frances, Davis, Roger J. , Tuveson, David A. (2015) Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. Pancreatology, 15(3, Sup) pp. S36.

Perna, D., Karreth, F. A., Rust, A. G., Perez-Mancera, P. A., Rashid, M., Iorio, F., Alifrangis, C., Arends, M. J., Bosenberg, M. W., Bollag, G., Tuveson, D. A. , Adams, D. J. (2015) BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. Proceedings of the National Academy of Sciences of the United States of America, 112(6) pp. E536-E545.

Boj, Sylvia F, Hwang, Chang-Il, Baker, Lindsey A, Chio, Iok In Christine, Engle, Dannielle D, Corbo, Vincenzo, Jager, Myrthe, Ponz-Sarvise, Mariano, Tiriac, Hervé, Spector, Mona S, Gracanin, Ana, Oni, Tobiloba, Yu, Kenneth H, van Boxtel, Ruben, Huch, Meritxell, Rivera, Keith D, Wilson, John P, Feigin, Michael E, Öhlund, Daniel, Handly-Santana, Abram, Ardito-Abraham, Christine M, Ludwig, Michael, Elyada, Ela, Alagesan, Brinda, Biffi, Giulia, Yordanov, Georgi N, Delcuze, Bethany, Creighton, Brianna, Wright, Kevin, Park, Youngkyu, Morsink, Folkert H M., Molenaar, I.  Quintus, Borel Rinkes, Inne H, Cuppen, Edwin, Hao, Yuan, Jin, Ying, Nijman, Isaac J, Iacobuzio-Donahue, Christine, Leach, Steven D, Pappin, Darryl J, Hammell, Molly, Klimstra, David S, Basturk, Olca, Hruban, Ralph H, Offerhaus, George Johan, Vries, Robert G J., Clevers, Hans , Tuveson, David A (2015) Organoid Models of Human and Mouse Ductal Pancreatic Cancer. Cell, 160(1-2) pp. 324-338.

Schlomann, U., Koller, G., Conrad, C., Ferdous, T., Golfi, P., Garcia, A. M., Hofling, S., Parsons, M., Costa, P., Soper, R., Bossard, M., Hagemann, T., Roshani, R., Sewald, N., Ketchem, R. R., Moss, M. L., Rasmussen, F. H., Miller, M. A., Lauffenburger, D. A., Tuveson, D. A., Nimsky, C. , Bartsch, J. W. (2015) ADAM8 as a drug target in pancreatic cancer. Nature Communications, 6 pp. 6175.

Naguib, A., Bencze, G., Engle, D. D., Chio, II, Herzka, T., Watrud, K., Bencze, S., Tuveson, D. A., Pappin, D. J. , Trotman, L. C. (2014) P53 Mutations Change Phosphatidylinositol Acyl Chain Composition. Cell Reports, 10(1) pp. 8-19.

Tuveson, D. (2014) Progress in pancreatic cancer modeling. Molecular Cancer Research, 12(Supple)

Chio, II, Yordanov, G. , Tuveson, D. (2014) MAX-ing out MYC: a novel small molecule inhibitor against MYC-dependent tumors. Journal of the National Cancer Institute, 106(12)

Ponz-Sarvise, M., Corbo, V., Ohlund, D., Oni, T., Handly-Santana, A., Engle, D., Tiriac, H., Chio, C., Feigin, M., Baker, L., Ardito-Abraham, C., Park, Y., Hwang, C., Elyada, E., Yu, K., Clevers, H. , Tuveson, D. A. (2014) Pancreatic ductal organoids as a new platform for drug discovery. European Journal of Cancer, 50 pp. 63-63.

Tuveson, D. A. (2014) Modeling pancreatic cancer biology and medicine. Molecular Cancer Research, 12(Supple)

Kultti, A., Zhao, C. M., Zimmerman, S., Osgood, R. J., Chen, Y. L., Symons, R., Jiang, P., Thompson, C. B., Tuveson, D. A., Frost, G. I., Shepard, H. M. , Huang, Z. D. (2014) Extracellular hyaluronan accumulation by hyaluronan synthase 3 promotes pancreatic cancer growth and modulates tumor microenvironment via epithelial-mesenchymal transition. Cancer Research, 74(19)

Espana-Agusti, J., Tuveson, D. A., Adams, D. J. , Matakidou, A. (2014) A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of mouse tubular epithelial cells. BJU International, 114(Supple) pp. 11-11.

Corbo, V., Ponz-Sarvise, M. , Tuveson, D. A. (2014) The RAS and YAP1 dance, who is leading?. EMBO journal, 33(21) pp. 3437-2438.

Sherman, Mara H, Yu, Ruth T, Engle, Dannielle D, Ding, Ning, Atkins, Annette R, Tiriac, Herve, Collisson, Eric A, Connor, Frances, Van Dyke, Terry, Kozlov, Serguei, Martin, Philip, Tseng, Tiffany W, Dawson, David W, Donahue, Timothy R, Masamune, Atsushi, Shimosegawa, Tooru, Apte, Minoti V, Wilson, Jeremy S, Ng, Beverly, Lau, Sue Lynn, Gunton, Jenny E, Wahl, Geoffrey M, Hunter, Tony, Drebin, Jeffrey A, O’Dwyer, Peter J, Liddle, Christopher, Tuveson, David A, Downes, Michael , Evans, Ronald M (2014) Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy. Cell, 159(1) pp. 80-93.

Ohlund, D., Elyada, E. , Tuveson, D. (2014) Fibroblast heterogeneity in the cancer wound. Journal of Experimental Medicine, 211(8) pp. 1503-23.

Kultti, A., Zhao, C. M., Singha, N. C., Zimmerman, S., Osgood, R. J., Symons, R., Jiang, P., Li, X. M., Thompson, C. B., Infante, J. R., Jacobetz, M. A., Tuveson, D. A., Frost, G. I., Shepard, H. M. , Huang, Z. D. (2014) Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment. Biomed Research International, pp. 15.

Chandel, N. S. , Tuveson, D. A. (2014) The Promise and Perils of Antioxidants for Cancer Patients. New England Journal of Medicine, 371(2) pp. 177-178.

Baumgart, S., Chen, N. M., Siveke, J. T., Konig, A., Zhang, J. S., Singh, S. K., Wolf, E., Bartkuhn, M., Esposito, I., Hessmann, E., Reinecke, J., Nikorowitsch, J., Brunner, M., Singh, G., Fernandez-Zapico, M. E., Smyrk, T., Bamlet, W. R., Eilers, M., Neesse, A., Gress, T. M., Billadeau, D. D., Tuveson, D., Urrutia, R. , Ellenrieder, V. (2014) Inflammation-Induced NFATc1-STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by Kras(G12D). Cancer Discovery, 4(6) pp. 688-701.

Bapiro, T. E., Frese, K. K., Courtin, A., Bramhall, J. L., Madhu, B., Cook, N., Neesse, A., Griffiths, J. R., Tuveson, D. A., Jodrell, D. I. , Richards, F. M. (2014) Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo. British Journal of Cancer, 111(2) pp. 318-325.

Davies, C. C., Harvey, E., McMahon, R. F. T., Finegan, K. G., Connor, F., Davis, R. J., Tuveson, D. A. , Tournier, C. (2014) Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. Cancer Research, 74(12) pp. 3344-3356.

Neesse, A., Michl, P., Tuveson, D. A. , Ellenrieder, V. (2014) nab-Paclitaxel: Novel Clinical and Experimental Evidence in Pancreatic Cancer. Zeitschrift fur Gastroenterologie, 52(4) pp. 360-366.

Feig, C., Jones, J. O., Kraman, M., Wells, R. J. B., Deonarine, A., Chan, D. S., Connell, C. M., Roberts, E. W., Zhao, Q., Caballero, O. L., Teichmann, S. A., Janowitz, T., Jodrell, D. I., Tuveson, D. A. , Fearon, D. T. (2013) Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(50) pp. 20212-20217.

Neesse, A., Frese, K. K., Chan, D. S., Bapiro, T. E., Howat, W. J., Richards, F. M., Ellenrieder, V., Jodrell, D. I. , Tuveson, D. A. (2013) SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice. Gut, 63(6) pp. 974-983.

Neesse, A., Frese, K. K., Bapiro, T. E., Nakagawa, T., Sternlicht, M. D., Seeley, T. W., Pilarsky, C., Jodrell, D. I., Spong, S. M. , Tuveson, D. A. (2013) CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(30) pp. 12325-30.

Roberts, E. W., Deonarine, A., Jones, J. O., Denton, A. E., Feig, C., Lyons, S. K., Espeli, M., Kraman, M., McKenna, B., Wells, R. J. B., Zhao, Q., Caballero, O. L., Larder, R., Coll, A. P., O'Rahilly, S., Brindle, K. M., Teichmann, S. A., Tuveson, D. A. , Fearon, D. T. (2013) Depletion of stromal cells expressing fibroblast activation protein-alpha from skeletal muscle and bone marrow results in cachexia and anemia. Journal of Experimental Medicine, 210(6) pp. 1137-1151.

Chin, L., De Sauvage, F., Egeblad, M., Olive, K. P., Tuveson, D. , Weiss, W. (2013) Recapitulating human cancer in a mouse. Nature Biotechnology, 31(5) pp. 392-395.

Mahajan, Ujwal Mukund, Teller, Steffen, Sendler, Matthias, Schwaiger, Theresa, Glöckl, Gunner, Aurich, Konstanze, Partecke, Lars Ivo, Hadlich, Steffen, Weiss, Frank Ulrich, Kühn, Jens P., Tuveson, David, Lerch, Markus M. , Mayerle, Julia (2013) In vivo imaging and targeted siRNA delivery using superparamagnetic nanoparticles in pancreatic ductal adenocarcinoma. Pancreatology, 13(3, Sup) pp. S19.

Jacobetz, M. A., Chan, D. S., Neesse, A., Bapiro, T. E., Cook, N., Frese, K. K., Feig, C., Nakagawa, T., Caldwell, M. E., Zecchini, H. I., Lolkema, M. P., Jiang, P., Kultti, A., Thompson, C. B., Maneval, D. C., Jodrell, D. I., Frost, G. I., Shepard, H. M., Skepper, J. N. , Tuveson, D. A. (2013) Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut, 62(1) pp. 112-20.

Neesse, A., Krug, S., Gress, T. M., Tuveson, D. A. , Michl, P. (2013) Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma. Onco Targets Ther, 7 pp. 33-43.

Feig, C., Gopinathan, A., Neesse, A., Chan, D. S., Cook, N. , Tuveson, D. A. (2012) The pancreas cancer microenvironment. Clin Cancer Res, 18(16) pp. 4266-76.

Perez-Mancera, P. A., Rust, A. G., van der Weyden, L., Kristiansen, G., Li, A., Sarver, A. L., Silverstein, K. A., Grutzmann, R., Aust, D., Rummele, P., Knosel, T., Herd, C., Stemple, D. L., Kettleborough, R., Brosnan, J. A., Li, A., Morgan, R., Knight, S., Yu, J., Stegeman, S., Collier, L. S., ten Hoeve, J. J., de Ridder, J., Klein, A. P., Goggins, M., Hruban, R. H., Chang, D. K., Biankin, A. V., Grimmond, S. M., Wessels, L. F., Wood, S. A., Iacobuzio-Donahue, C. A., Pilarsky, C., Largaespada, D. A., Adams, D. J. , Tuveson, D. A. (2012) The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature, 486(7402) pp. 266-70.

Pérez-Mancera, Pedro A, Guerra, Carmen, Barbacid, Mariano , Tuveson, David A (2012) What we have learned about pancreatic cancer from mouse models.. Gastroenterology, 142(5) pp. 1079-1092.

Cook, N., Frese, K. K., Bapiro, T. E., Jacobetz, M. A., Gopinathan, A., Miller, J. L., Rao, S. S., Demuth, T., Howat, W. J., Jodrell, D. I. , Tuveson, D. A. (2012) Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma. J Exp Med, 209(3) pp. 437-44.

Frese, K. K., Neesse, A., Cook, N., Bapiro, T. E., Lolkema, M. P., Jodrell, D. I. , Tuveson, D. A. (2012) nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer. Cancer Discov, 2(3) pp. 260-9.

Tuveson, David A , Neoptolemos, John P (2012) Understanding Metastasis in Pancreatic Cancer: A Call for New Clinical Approaches. Cell, 148(1–2) pp. 21-23.

Maniati, Eleni, Bossard, Maud, Cook, Natalie, Candido, Juliana B, Emami-Shahri, Nia, Nedospasov, Sergei A, Balkwill, Frances R, Tuveson, David A , Hagemann, Thorsten (2011) Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice.. Journal of Clinical Investigation, 121(12) pp. 4685-4699.

Pearson, H. B., Perez-Mancera, P. A., Dow, L. E., Ryan, A., Tennstedt, P., Bogani, D., Elsum, I., Greenfield, A., Tuveson, D. A., Simon, R. , Humbert, P. O. (2011) SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. Journal of Clinical Investigation, 121(11) pp. 4257-4267.

DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., Scrimieri, F., Winter, J. M., Hruban, R. H., Iacobuzio-Donahue, C., Kern, S. E., Blair, I. A. , Tuveson, D. A. (2011) Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature, 475(7354) pp. 106-9.

Kraman, M., Bambrough, P. J., Arnold, J. N., Roberts, E. W., Magiera, L., Jones, J. O., Gopinathan, A., Tuveson, D. A. , Fearon, D. T. (2010) Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science, 330(6005) pp. 827-30.