Additional materials of the author at
CSHL Institutional Repository

Qian, Zhe, Song, Dongyan, Ipsaro, Jonathan J, Bautista, Carmelita, Joshua-Tor, Leemor, Yeh, Johannes T-H , Tonks, Nicholas K (2023) Manipulating PTPRD function with ectodomain antibodies. Genes and Development,

Tonks, Nicholas K (2023) Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow. IUBMB Life, 75(4) pp. 337-352.

Bonham, ChristopherA, Mandati, Vinay, Singh, RakeshK, Pappin, DarrylJ , Tonks, NicholasK (2023) Coupling substrate-trapping with proximity-labeling to identify protein tyrosine phosphatase PTP1B signaling networks. Journal of Biological Chemistry, pp. 104582. Elsevier BV.

Song, Dongyan, Adrover, Jose M, Felice, Christy, Christensen, Lisa N, He, Xue-Yan, Merrill, Joseph R, Wilkinson, John E, Janowitz, Tobias, Lyons, Scott K, Egeblad, Mikala , Tonks, Nicholas K (2022) PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils. JCI Insight, 7(14) pp. e158199.

Wiede, Florian, Lu, Kun-Hui, Du, Xin, Zeissig, Mara N, Xu, Rachel, Goh, Pei Kee, Xirouchaki, Chrysovalantou E, Hogarth, Samuel J, Greatorex, Spencer, Sek, Kevin, Daly, Roger J, Beavis, Paul A, Darcy, Phillip K, Tonks, Nicholas K , Tiganis, Tony (2021) PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity.. Cancer Discovery,

Ge, Eva J, Bush, Ashley I, Casini, Angela, Cobine, Paul A, Cross, Justin R, DeNicola, Gina M, Dou, Q Ping, Franz, Katherine J, Gohil, Vishal M, Gupta, Sanjeev, Kaler, Stephen G, Lutsenko, Svetlana, Mittal, Vivek, Petris, Michael J, Polishchuk, Roman, Ralle, Martina, Schilsky, Michael L, Tonks, Nicholas K, Vahdat, Linda T, Van Aelst, Linda, Xi, Dan, Yuan, Peng, Brady, Donita C , Chang, Christopher J (2021) Connecting copper and cancer: from transition metal signalling to metalloplasia. Nature Reviews Cancer,

Bencze, G., Bencze, S., Rivera, K. D., Watson, J. D., Orfi, L., Tonks, N. K. , Pappin, D. J. (2020) Mito-oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth. Sci Rep, 10(1) pp. 14174.

Fu, P., Ramchandran, R., Shaaya, M., Huang, L., Ebenezer, D.L., Jiang, Y., Komarova, Y., Vogel, S.M., Malik, A.B., Minshall, R.D., Du, G., Tonks, N. K. , Natarajan, V. (2020) Phospholipase D2 Restores Endothelial Barrier Function by Promoting PTPN14-mediated VE-cadherin Dephosphorylation. Journal of Biological Chemistry, 295(22) pp. 7669-7685.

Londhe, A. D., Bergeron, A., Curley, S. M., Zhang, F., Rivera, K. D., Kannan, A., Coulis, G., Rizvi, S. H. M., Kim, S. J., Pappin, D. J., Tonks, N. K., Linhardt, R. J. , Boivin, B. (2019) Regulation of PTP1B activation through disruption of redox-complex formation. Nat Chem Biol, 16(2) pp. 122-125.

Krishnan, N., Felice, C., Rivera, K., Pappin, D. J. , Tonks, N. K. (2018) DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease. Genes Dev, 32(13-14) pp. 944-952.

Zhang, Jiali, Wang, Zuo, Zhang, Siwei, Chen, Yanxun, Xiong, Xuexue, Li, Xiaojuan, Tonks, Nicholas K. , Fan, Gaofeng (2018) Spatial regulation of signaling by the coordinated action of the protein tyrosine kinases MET and FER. Cellular Signalling, 50 pp. 100-110.

Krishnan, N., Konidaris, K. F., Gasser, G. , Tonks, N. K. (2018) A potent, selective and orally bioavailable inhibitor of the protein tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem, 293(5) pp. 1517-1525.

Krishnan, N., Bonham, C. A., Rus, I. A., Shrestha, O. K., Gauss, C. M., Haque, A., Tocilj, A., Joshua-Tor, L. , Tonks, N. K. (2018) Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development. Nat Commun, 9(1) pp. 283.

Zhang, S., Fan, G., Hao, Y., Hammell, M., Wilkinson, J. E. , Tonks, N. K. (2017) Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase. Genes Dev, 31(19) pp. 1939-57.

Gurung, Prajwal, Fan, Gaofeng, Lukens, John R., Vogel, Peter, Tonks, Nicholas K. , Kanneganti, Thirumala-Devi (2017) Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease. Immunity, 46(4) pp. 635-648.

Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Tonks, N. K., Mody, N., Wilson, H. M. , Delibegovic, M. (2017) Genetic deletion and pharmacological inhibition of macrophage protein tyrosine phosphatase 1B (PTP1B) improves global glucose and lipid homeostasis and protects against atherosclerotic plaque formation in mouse models of atherosclerosis. Diabetic Medicine, 34(Supple) pp. 26-27.

Fan, G., Zhang, S., Gao, Y., Greer, P. A. , Tonks, N. K. (2016) HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancer. Genes Dev, 30(13) pp. 1542-57.

Krishnan, Navasona , Tonks, Nicholas K. (2015) Anxious moments for the protein tyrosine phosphatase PTP1B. Trends in Neurosciences, 38(8) pp. 462-465.

Moskal, D., Tonks, N. K. , Lucito, R. (2015) Alteration of the protein tyrosine phosphatome in cancer. Cancer Research, 75(Supple) pp. Abstract 1933.

Krishnan, N., Krishnan, K., Connors, C. R., Choy, M. S., Page, R., Peti, W., Van Aelst, L., Shea, S. D. , Tonks, N. K. (2015) PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest, 125(8) pp. 3163-3177.

Fan, G., Aleem, S., Yang, M., Miller, W. T. , Tonks, N. K. (2015) Protein Tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and BRK. Journal of Biological Chemistry, 290(26) pp. 15934-15947.

Ramesh, M., Krishnan, N., Muthuswamy, S. K. , Tonks, N. K. (2015) A Novel Phosphatidic Acid-Protein Tyrosine Phosphatase D2 Axis is Essential for ERBB2 Signaling in Mammary Epithelial Cells. Journal of Biological Chemistry, 290(15) pp. 9646-9659.

Fan, G., Wrzeszczynski, K. O., Fu, C., Su, G., Pappin, D. J., Lucito, R. , Tonks, N. K. (2015) A quantitative proteomics-based signature of platinum sensitivity in ovarian cancer cell lines. Biochem J, 465(3) pp. 433-42.

Chaudhary, F., Lucito, R. , Tonks, N. K. (2014) Missing-in-Metastasis regulates cell motility and invasion via PTPdelta-mediated changes in SRC activity. Biochemical Journal, 465(1) pp. 89-101.

Tonks, N. , Lucito, R. (2014) Global assessment of the protein tyrosine phosphatome in cancer. Cancer Research, 74(19)

Yang, M., Haase, A. D., Huang, F. K., Coulis, G., Rivera, K. D., Dickinson, B. C., Chang, C. J., Pappin, D. J., Neubert, T. A., Hannon, G. J., Boivin, B. , Tonks, N. K. (2014) Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence. Mol Cell, 55(5) pp. 782-790.

Pulido, R., Baker, S. J., Barata, J. T., Carracedo, A., Cid, V. J., Chin-Sang, I. D., Dave, V., den Hertog, J., Devreotes, P., Eickholt, B. J., Eng, C., Furnari, F. B., Georgescu, M. M., Gericke, A., Hopkins, B., Jiang, X., Lee, S. R., Losche, M., Malaney, P., Matias-Guiu, X., Molina, M., Pandolfi, P. P., Parsons, R., Pinton, P., Rivas, C., Rocha, R. M., Rodriguez, M. S., Ross, A. H., Serrano, M., Stambolic, V., Stiles, B., Suzuki, A., Tan, S. S., Tonks, N. K., Trotman, L. C., Wolff, N., Woscholski, R., Wu, H. , Leslie, N. R. (2014) A Unified Nomenclature and Amino Acid Numbering for Human PTEN. Science signaling, 7(332) pp. pe15.

Schwertassek, U., Haque, A., Krishnan, N., Greiner, R., Weingarten, L., Dick, T. P. , Tonks, N. K. (2014) Reactivation of oxidized PTP1B and PTEN by Thioredoxin 1. Febs Journal, 281(16) pp. 3545-3558.

Krishnan, N., Koveal, D., Miller, D. H., Xue, B., Akshinthala, S. D., Kragelj, J., Jensen, M. R., Gauss, C. M., Page, R., Blackledge, M., Muthuswamy, S. K., Peti, W. , Tonks, N. K. (2014) Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature Chemical Biology, 10(7) pp. 558-566.

Mondol, A. S., Tonks, N. K. , Kamata, T. (2014) Nox4 redox regulation of PTP1B contributes to the proliferation and migration of glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C. Free Radical Biology and Medicine, 67 pp. 285-91.

Boivin, B., Chaudhary, F., Dickinson, B. C., Haque, A., Pero, S. C., Chang, C. J. , Tonks, N. K. (2013) Receptor protein-tyrosine phosphatase α regulates focal adhesion kinase phosphorylation and ErbB2 oncoprotein mediated mammary epithelial cell motility. Journal of Biological Chemistry, 288(52) pp. 36926-36935.

Dagnell, M., Frijhoff, J., Pader, I., Augsten, M., Boivin, B., Xu, J., Mandal, P. K., Tonks, N. K., Hellberg, C., Conrad, M., Arnér, E. S. J. , Östman, A. (2013) Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-ß receptor tyrosine kinase signaling. Proceedings of the National Academy of Sciences of the United States of America, 110(33) pp. 13398-13403.

Fan, G., Lin, G., Lucito, R. , Tonks, N. K. (2013) Protein Tyrosine Phosphatase 1B Antagonized Signaling by IGF-1 Receptor and BRK/PTK6 in Ovarian Cancer Cells. Journal of Biological Chemistry, 288(34) pp. 24923-29434.

Tonks, N. K. (2013) Protein Tyrosine Phosphatases: Critical Regulators of Signaling in Cancer. Faseb Journal, 27(1)

Krishnan, N., Bencze, G., Cohen, P. , Tonks, N. K. (2013) The anti-inflammatory compound BAY 11-7082 is a potent inhibitor of Protein Tyrosine Phosphatases. FEBS Journal, 280(12) pp. 2830-2841.

Wrzeszczynski, K. O., Fan, G. F., Fu, C. X., Pappin, D. J., Lucito, R. , Tonks, N. K. (2013) Proteomic identification of carboplatin resistance in ovarian cancer cells. Cancer Research, 73(8 Supp) pp. 2502.

Lindtner, C., Scherer, T., Zielinski, E., Filatova, N., Fasshauer, M., Tonks, N. K., Puchowicz, M. , Buettner, C. (2013) Binge Drinking Induces Whole-Body Insulin Resistance by Impairing Hypothalamic Insulin Action. Science Translational Medicine, 5(170)

Tonks, N. K. (2013) Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction. Febs Journal, 280(2) pp. 346-378.

Haque, A. , Tonks, N. K. (2012) The use of phage display to generate conformation-sensor recombinant antibodies. Nature Protocols, 7(12) pp. 2127-43.

Tonks, N. (2012) HARNESSING REDOX REGULATION OF PROTEIN TYROSINE PHOSPHATASES. Free Radical Biology and Medicine, 53(Supple) pp. S3-S3.

Yu, M., Lin, G., Arshadi, N., Kalatskaya, I., Xue, B., Haider, S., Nguyen, F., Boutros, P. C., Elson, A., Muthuswamy, L. B., Tonks, N. K. , Muthuswamy, S. K. (2012) Expression profiling during mammary epithelial cell 3D morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2 mediated transformation. Mol Cell Biol, 32(19) pp. 3913-3924.

Zhang, X. C., Piccini, A., Myers, M. P., Van Aelst, L. , Tonks, N. K. (2012) Functional analysis of the protein phosphatase activity of PTEN. Biochem J, 444(3) pp. 457-64.

Haque, Aftabul, Andersen, J. N., Salmeen, A., Barford, D. , Tonks, N. K. (2011) Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity. Cell, 147(1) pp. 185-198.

Lin, G., Aranda, V., Muthuswamy, S. K. , Tonks, N. K. (2011) Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes & Development, 25(13) pp. 1412-1425.

Hyun, S. W., Anglin, I. E., Liu, A., Yang, S., Sorkin, J. D., Lillehoj, E., Tonks, N. K., Passaniti, A. , Goldblum, S. E. (2011) Diverse injurious stimuli reduce protein tyrosine phosphatase-μ expression and enhance epidermal growth factor receptor signaling in human airway epithelia. Experimental Lung Research, 37(6) pp. 327-343.

Krishnan, N., Fu, C., Pappin, D. J. , Tonks, N. K. (2011) H2S-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Science Signaling, 4(203)

Boivin, B., Tonks, N. K. , Yang, M. (2010) Targeting the reversibly oxidized protein tyrosine phosphatase superfamily. Science Signaling, 3(137)

Schwertassek, U., Buckley, D. A., Xu, C. F., Lindsay, A. J., McCaffrey, M. W., Neubert, T. A. , Tonks, N. K. (2010) Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis. Febs Journal, 277(11) pp. 2463-2473.

Hinton, S. D., Myers, M. P., Roggero, V. R., Allison, L. A. , Tonks, N. K. (2010) The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation. Biochemical Journal, 427 pp. 349-357.

Jung, S. K., Jeong, D. G., Chung, S. J., Kim, J. H., Park, B. C., Tonks, N. K., Ryu, S. E. , Kim, S. J. (2010) Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor. FASEB J., 24(2) pp. 560-569.

Tonks, N. K. (2009) Pseudophosphatases: grab and hold on. Cell, 139(3) pp. 464-5.

Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., Stepto, N., Wu, B., Mitchell, C. A., Tonks, N. K., Watt, M. J., Febbraio, M. A., Crack, P. J., Andrikopoulos, S. , Tiganis, T. (2009) Reactive Oxygen Species Enhance Insulin Sensitivity. Cell Metabolism, 10(4) pp. 260-272.

Krishnan, N., Jeong, D. G., Jung, S.-k., Ryu, S. E., Xiao, A., Allis, C. D., Kim, S. J. , Tonks, N. K. (2009) Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. Journal of Biological Chemistry, 284(24) pp. 16066-16070.

Hemmings, B. A., Restuccia, D. , Tonks, N. K. (2009) Targeting the Kinome II. Curr Opin Cell Biol, 21(2) pp. 135-139.

Boivin, B., Zhang, S. H., Arbiser, J. L., Zhang, Z.-Y. , Tonks, N. K. (2008) A modified cysteinyl-labeling assay reveals reversible oxidation of classical and dual specificity phosphatases in angiomyolipoma cells. Proc Natl Acad Sci U S A, 105 (29) pp. 9959-9964.

Tabet, F., Schiffrin, E. L., Callera, G., He, Y., Yao, G., Ostman, A., Kappert, K., Tonks, N. K. , Touyz, R. M. (2008) Redox-Sensitive Signaling by Angiotensin II Involves Oxidative Inactivation and Blunted Phosphorylation of Protein Tyrosine Phosphatase SHP-2 in Vascular Smooth Muscle Cells From SHR. Circ Res, 103(2) pp. 149-158.

Juarez, J. C., Manuia, M., Burnett, M. E., Betancourt, O., Boivin, B., Shaw, D. E., Tonks, N. K., Mazar, A. P. , Donate, F. (2008) Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling. Proc Natl Acad Sci U S A, 105(20) pp. 7147-7152.

Lou, Y.-W., Chen, Y.-Y., Hsu, S.-F., Chen, R.-K., Lee, C.-L., Khoo, K.-H., Tonks, N. K. , Meng, T.-C. (2008) Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells. FEBS Journal, 275(1) pp. 69-88.

Tonks, N. , Krishnan, N. (2008) Regulation of Protein Tyrsoine Phosphatase by Hydrogen Sulphide. Free Radical Biology and Medicine, 45(Suppl.) pp. S18-S19.

Tonks, N. , Krishnan, N. (2008) Unraveling the Mechanism of Redox Regulation in Protein Tyrosine Phosphatases. Free Radical Biology and Medicine, 45(Suppl.) pp. S62-S62.

Tonks, N. K. (2007) The protein tyrosine phosphatase superfamily of enzymes. Toxicology Letters, 172(Supple) pp. S10-S11.

Tonks, N. K. , Muthuswamy, S. K. (2007) A Brake Becomes an Accelerator: PTP1B-A New Therapeutic Target for Breast Cancer. Cancer Cell, 11(3) pp. 214-6.

Tonks, N. K. (2006) Protein tyrosine phosphatases: from genes, to function, to disease. Nat Rev Mol Cell Biol, 7(11) pp. 833-46.

Nelson, K. K., Subbaram, S., Connor, K. M., Dasgupta, J., Ha, X. F., Meng, T. C., Tonks, N. K. , Melendez, J. A. (2006) Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs. Journal of Biological Chemistry, 281(20) pp. 14100-14110.

Tonks, N. K. (2005) Redox redux: revisiting PTPs and the control of cell signaling. Cell, 121(5) pp. 667-70.

Sui, X. F., Kiser, T. D., Hyun, S. W., Angelini, D. J., Del Vecchio, R. L., Young, B. A., Hasday, J. D., Romer, L. H., Passaniti, A., Tonks, N. K. , Goldblum, S. E. (2005) Receptor protein tyrosine phosphatase mu regulates the paracellular pathway in human lung microvascular endothelia. American Journal of Pathology, 166(4) pp. 1247-1258.

Del Vecchio, R. L. , Tonks, N. K. (2005) The conserved immunoglobulin domain controls the subcellular localization of the homophilic adhesion receptor protein-tyrosine phosphatase mu. J Biol Chem, 280(2) pp. 1603-12.

Andersen, J. N., Del Vecchio, R. L., Kannan, N., Gergel, J., Neuwald, A. F. , Tonks, N.K. (2005) Computational analysis of protein tyrosine phosphatases: practical guide to bioinformatics and data resources. Methods, 35(1) pp. 90-114.

Galic, S., Hauser, C., Kahn, B. B., Haj, F. G., Neel, B. G., Tonks, N. K. , Tiganis, T. (2005) Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Molecular and Cellular Biology, 25(2) pp. 819-829.

Meng, T. C., Hsu, S. F. , Tonks, N. K. (2005) Development of a modified in-gel assay to identify protein tyrosine phosphatases that are oxidized and inactivated in vivo. Methods, 35(1) pp. 28-36.

Hyun, S. W., Sui, X., Del Vecchio, R. L., Tonks, N. K., Passaniti, A. , Goldblum, S. E. (2004) Protein tyrosine phosphatase (PTP) mu regulates endothelial cell (EC) proliferation, adhesion and migration. Molecular Biology of the Cell, 15 pp. 226A-226A.

Sui, X., Hyun, S. W., Kiser, T. D., Del Vecchio, R. L., Tonks, N. K., Passaniti, A. , Goldblum, S. E. (2004) Receptor protein tyrosine phosphatase (PTP) mu regulates the endothelial paracellular pathway. Molecular Biology of the Cell, 15 pp. 428A-428A.

Chen, H. H., Luche, R., Wei, B. , Tonks, N. K. (2004) Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2. J Biol Chem, 279(40) pp. 41404-13.

Meng, T. C., Buckley, D. A., Galic, S., Tiganis, T. , Tonks, N. K. (2004) Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B. J Biol Chem, 279(36) pp. 37716-25.

Bukczynska, P., Klingler-Hoffmann, M., Mitchelhill, K. I., Lam, M. H. C., Ciccomancini, M., Tonks, N. K., Sarcevic, B., Kemp, B. E. , Tiganis, T. (2004) The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis. Biochemical Journal, 380 pp. 939-949.

Andersen, J. N., Jansen, P. G., Echwald, S. M., Mortensen, O. H., Fukada, T., Del Vecchio, R., Tonks, N. K. , Moller, N. P. (2004) A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. FASEB J, 18(1) pp. 8-30.

Torres, J., Rodriguez, J., Myers, M. P., Valiente, M., Graves, J. D., Tonks, N. K. , Pulido, R. (2003) Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3 - Implications for the control of protein stability and PTEN-protein interactions. Journal of Biological Chemistry, 278(33) pp. 30652-30660.

Gray, C. H., Good, V. M., Tonks, N. K. , Barford, D. (2003) The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. Embo Journal, 22(14) pp. 3524-3535.

Tonks, N. K. (2003) PTP1B: From the sidelines to the front lines!. Febs Letters, 546(1) pp. 140-148.

Salmeen, A., Andersen, J. N., Myers, M. P., Meng, T. C., Hinks, J. A., Tonks, N. K. , Barford, D. (2003) Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature, 423(6941) pp. 769-773.

Galic, S., Klingler-Hoffmann, M., Fodero-Tavoletti, M. T., Puryer, M. A., Meng, T. C., Tonks, N. K. , Tiganis, T. (2003) Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP. Molecular and Cellular Biology, 23(6) pp. 2096-2108.

Palka, H. L., Park, M. , Tonks, N. K. (2003) Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. Journal of Biological Chemistry, 278(8) pp. 5728-35.

Fukada, T. , Tonks, N. K. (2003) Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling. Embo Journal, 22(3) pp. 479-493.

Yart, A., Roche, S., Wetzker, R., Laffargue, M., Tonks, N., Mayeux, P., Chap, H. , Raynal, P. (2002) A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. Journal of Biological Chemistry, 277(24) pp. 21167-21178.

Harrington, R. J., Gutch, M. J., Hengartner, M. O., Tonks, N. K. , Chisholm, A. D. (2002) The C-elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis. Development, 129(9) pp. 2141-2153.

Boettner, B. , Van Aelst, L. (2002) The role of Rho GTPases in disease development. Gene, 286(2) pp. 155-74.

Mayo, L. D., Dixon, J. E., Durden, D. L., Tonks, N. K. , Donner, D. B. (2002) PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. Journal of Biological Chemistry, 277(7) pp. 5484-5489.

Meng, T. C., Fukada, T. , Tonks, N. K. (2002) Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Molecular Cell, 9(2) pp. 387-399.

Nelson, K., Meng, T. C., Tonks, N. , Melendez, J. A. (2002) Mitochondrial H2O2 enhances matrix metalloproteinase expression by protein tyrosine phosphatase inactivation. Free Radical Biology and Medicine, 33 pp. S355-S355.

Myers, M. P., Andersen, J. N., Cheng, A., Tremblay, M. L., Horvath, C. M., Parisien, J. P., Salmeen, A., Barford, D. , Tonks, N. K. (2001) TYK2 and JAR2 are substrates of protein-tyrosine phosphatase 1B. Journal of Biological Chemistry, 276(51) pp. 47771-47774.

Andersen, J. N., Mortensen, O. H., Peters, G. H., Drake, P. G., Iversen, L. F., Olsen, O. H., Jansen, P. G., Andersen, H. S., Tonks, N. K. , Moller, N. P. H. (2001) Structural and evolutionary relationships among protein tyrosine phosphatase domains. Molecular and Cellular Biology, 21(21) pp. 7117-7136.

Shen, Y., Luche, R., Wei, B., Gordon, M. L., Diltz, C. D. , Tonks, N. K. (2001) Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. Proceedings of the National Academy of Sciences of the United States of America, 98(24) pp. 13613-13618.

Sui, X., Kiser, T. D., Del Vecchio, R. L., Young, B. A., Gregoryev, D., Garcia, J. G. N., Tonks, N. K. , Goldblum, S. E. (2001) PTP mu regulates the tyrosine phosphorylation state of VE-cadherin and the pulmonary microvascular endothelial paracellular pathway. Molecular Biology of the Cell, 12 pp. 158A-158A.

Lam, M. H. C., Michell, B. J., Fodero-Tavoletti, M. T., Kemp, B. E., Tonks, N. K. , Tiganis, T. (2001) Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP. Journal of Biological Chemistry, 276(40) pp. 37700-37707.

Fukada, T. , Tonks, N. K. (2001) The reciprocal role of Egr-1 and Sp family proteins in regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase. Journal of Biological Chemistry, 276(27) pp. 25512-25519.

Yang, J., Dokurno, P., Tonks, N. K. , Barford, D. (2001) Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion. Embo Journal, 20(14) pp. 3645-3656.

Tonks, N. K. , Neel, B. G. (2001) Combinatorial control of the specificity of protein tyrosine phosphatases. Current Opinion in Cell Biology, 13(2) pp. 182-195.

Wen, S. H., Stolarov, J., Myers, M. P., Su, J. D., Wigler, M. H., Tonks, N. K. , Durden, D. L. (2001) PTEN controls tumor-induced angiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 98(8) pp. 4622-4627.

Yart, A., Laffargue, M., Mayeux, P., Chretien, S., Peres, C., Tonks, N., Roche, S., Payrastre, B., Chap, H. , Raynal, P. (2001) A critical pole for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of Ras and mitogen-activated protein kinases by epidermal growth factor. Journal of Biological Chemistry, 276(12) pp. 8856-8864.

Lavoie, C., Chevet, E., Roy, L., Tonks, N. K., Fazel, A., Posner, B. I., Paiement, J. , Bergeron, J. J. M. (2000) Tyrosine phosphorylation of p97 regulates transitional endoplasmic reticulum assembly in vitro. Proceedings of the National Academy of Sciences of the United States of America, 97(25) pp. 13637-13642.

Salmeen, A., Andersen, J. N., Myers, M. P., Tonks, N. K. , Barford, D. (2000) Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Molecular Cell, 6(6) pp. 1401-1412.

Tonks, N. K. (2000) From structure to function of protein tyrosine phosphatases. Abstracts of Papers of the American Chemical Society, 219 pp. U7-U7.

Tonks, N. K. , Myers, M. P. (1999) Structural assets of a tumor suppressor. Science, 286(5447) pp. 2096-2097.

Tiganis, T., Kemp, B. E. , Tonks, N. K. (1999) The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling. Journal of Biological Chemistry, 274(39) pp. 27768-27775.

Zhang, S. H., Liu, J. P., Kobayashi, R. , Tonks, N. K. (1999) Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1. Journal of Biological Chemistry, 274(25) pp. 17806-17812.

Bianchi, C., Sellke, F. W., Del Vecchio, R. L., Tonks, N. K. , Neel, B. G. (1999) Receptor-type protein-tyrosine phosphatase mu is expressed in specific vascular endothelial beds in vivo. Experimental Cell Research, 248(1) pp. 329-338.

Garton, A. J. , Tonks, N. K. (1999) Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST. Journal of Biological Chemistry, 274(6) pp. 3811-3818.

Li, J., Simpson, L., Takahashi, M., Miliaresis, C., Myers, M. P., Tonks, N. , Parsons, R. (1998) The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Research, 58(24) pp. 5667-5672.

Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, J., Stolarov, J. P., Hemmings, B. A., Wigler, M. H., Downes, C. P. , Tonks, N. K. (1998) The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A, 95(23) pp. 13513-8.

LaMontagne, K. R., Hannon, G. , Tonks, N. K. (1998) Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of Rat-1 fibroblasts and promotes differentiation of K562 cells. Proceedings of the National Academy of Sciences of the United States of America, 95(24) pp. 14094-14099.

La Montagne, K. R., Flint, A. J., Franza, B. R., Pendergast, A. M. , Tonks, N. K. (1998) Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo. Molecular and Cellular Biology, 18(5) pp. 2965-2975.

Brady-Kalnay, S. M., Mourton, T., Nixon, J. P., Pietz, G. E., Kinch, M., Chen, H. Y., Brackenbury, R., Rimm, D. L., Del Vecchio, R. L. , Tonks, N. K. (1998) Dynamic interaction of PTP mu with multiple cadherins in vivo. Journal of Cell Biology, 141(1) pp. 287-296.

Pannifer, A. D. B., Flint, A. J., Tonks, N. K. , Barford, D. (1998) Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by X-ray crystallography. Journal of Biological Chemistry, 273(17) pp. 10454-10462.

Tiganis, T., Bennett, A. M., Ravichandran, K. S. , Tonks, N. K. (1998) Epidermal growth factor receptor and the adaptor protein p52(Shc) are specific substrates of T-cell protein tyrosine phosphatase. Molecular and Cellular Biology, 18(3) pp. 1622-1634.

Gutch, M. J., Flint, A. J., Keller, J., Tonks, N. K. , Hengartner, M. O. (1998) The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. Genes & Development, 12(4) pp. 571-585.

Tonks, N. K. (1998) From structure to function of protein tyrosine phosphatases. Naunyn-Schmiedebergs Archives of Pharmacology, 358(1) pp. R377-R377.

Myers, M. P. , Tonks, N. K. (1997) PTEN: Sometimes taking it off can be better than putting it on. American Journal of Human Genetics, 61(6) pp. 1234-1238.

Bennett, A. M. , Tonks, N. K. (1997) Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases. Science, 278(5341) pp. 1288-1291.

Hao, L. N., Tiganis, T., Tonks, N. K. , Charbonneau, H. (1997) The noncatalytic C-terminal segment of the T cell protein tyrosine phosphatase regulates activity via an intramolecular mechanism. Journal of Biological Chemistry, 272(46) pp. 29322-29329.

Hoffmann, K. M. V., Tonks, N. K. , Barford, D. (1997) The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu. Journal of Biological Chemistry, 272(44) pp. 27505-27508.

Zhang, S. H., Kobayashi, R., Graves, P. R., Piwnica-Worms, H. , Tonks, N. K. (1997) Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3 beta protein. Journal of Biological Chemistry, 272(43) pp. 27281-27287.

Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R. , Tonks, N. K. (1997) P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A, 94(17) pp. 9052-7.

Garton, A. J., Burnham, M. R., Bouton, A. H. , Tonks, N. K. (1997) Association of PTP-PEST with the SH3 domain of p130(cas); a novel mechanism of protein tyrosine phosphatase substrate recognition. Oncogene, 15(8) pp. 877-885.

Tiganis, T., Flint, A. J., Adam, S. A. , Tonks, N. K. (1997) Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97. Journal of Biological Chemistry, 272(34) pp. 21548-21557.

Tonks, N. K. (1997) From structure to function of protein tyrosine phosphatases. Faseb Journal, 11(9) pp. A1012-A1012.

Fuller, S. J., Davies, E. L., Gillespie Brown, J., Sun, H. , Tonks, N. K. (1997) Mitogen-activated protein kinase phosphatase 1 inhibits the stimulation of gene expression by hypertrophic agonists in cardiac myocytes. Biochemical Journal, 323 pp. 313-319.

Neel, B. G. , Tonks, N. K. (1997) Protein tyrosine phosphatases in signal transduction. Current Opinion in Cell Biology, 9(2) pp. 193-204.

Flint, A. J., Tiganis, T., Barford, D. , Tonks, N. K. (1997) Development of ''substrate-trapping'' mutants to identify physiological substrates of protein tyrosine phosphatases. Proceedings of the National Academy of Sciences of the United States of America, 94(5) pp. 1680-1685.

Zhang, S. H. , Tonks, N. K. (1996) Phosphorylation-dependent association of band 4.1-related protein tyrosine phosphatase PTPH1 and 14-3-3B. Molecular Biology of the Cell, 7 pp. 83-83.

Garton, A. J., Flint, A. J. , Tonks, N. K. (1996) Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. Molecular and Cellular Biology, 16(11) pp. 6408-6418.

MacKintosh, C., Garton, A. J., McDonnell, A., Barford, D., Cohen, P. T. W., Tonks, N. K. , Cohen, P. (1996) Further evidence that inhibitor-2 acts like a chaperone to fold PP1 into its native conformation. Febs Letters, 397(2-3) pp. 235-238.

Tonks, N. K. , Neel, B. G. (1996) From form to function: Signaling by protein tyrosine phosphatases. Cell, 87(3) pp. 365-368.

Park, C. Y., La Montagne, K. R., Tonks, N. K. , Hayman, M. J. (1996) Cloning and expression of the chicken protein tyrosine phosphatase SH-PTP2. Gene, 177(1-2) pp. 93-97.

Tonks, N. K. (1996) Protein tyrosine phosphatases and the control of the cellular signalling responses. Faseb Journal, 10(6) pp. P13-P13.

Tonks, N. K. (1996) Protein tyrosine phosphatases and the control of cellular signaling responses. Advances in Pharmacology, 36 pp. 91-119.

Barford, D., Jia, Z. C. , Tonks, N. K. (1995) Protein tyrosine phosphatases take off. Nature Structural Biology, 2(12) pp. 1043-1053.

Brady-Kalnay, S. M., Rimm, D. L. , Tonks, N. K. (1995) The receptor protein-tyrosine-phosphatase PTP-mu associates with cadherins and catenins. Molecular Biology of the Cell, 6 pp. 676-676.

Brady-Kalnay, S. M. , Tonks, N. K. (1995) Protein tyrosine phosphatases as adhesion receptors. Current Opinion in Cell Biology, 7(5) pp. 650-657.

Brady-Kalnay, S. M., Rimm, D. L. , Tonks, N. K. (1995) Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo. Journal of Cell Biology, 130(4) pp. 977-986.

Zhang, S. H., Eckberg, W. R., Yang, Q., Samatar, A. A. , Tonks, N. K. (1995) Biochemical characterization of a human band 4.1-related protein-tyrosine phosphatase, PTPH1. Journal of Biological Chemistry, 270(34) pp. 20067-20072.

Jia, Z. C., Barford, D., Flint, A. J. , Tonks, N. K. (1995) Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. Science, 268(5218) pp. 1754-1758.

Brondello, J. M., McKenzie, F. R., Sun, H., Tonks, N. K. , Pouyssegur, J. (1995) Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts. Oncogene, 10(10) pp. 1895-1904.

La Montagne, K. R., Pendergast, A. M., Franza, B. R. , Tonks, N. K. (1995) Enhanced expression of a protein-tyrosine phosphatase in cells expressing P210BCR/ABL. Journal of Cellular Biochemistry, pp. 65-65.

Brady-Kalnay, S. M. , Tonks, N. K. (1994) Identification of the homophilic binding site of the receptor protein tyrosine phosphatase PTP mu. Journal of Biological Chemistry, 269(45) pp. 28472-28477.

Minshull, J., Sun, H., Tonks, N. K. , Murray, A. W. (1994) A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts. Cell, 79(3) pp. 475-486.

Sun, H. , Tonks, N. K. (1994) The coordinated action of protein tyrosine phosphatases and kinases in cell signaling. Trends in Biochemical Sciences, 19(11) pp. 480-485.

Ostman, A., Yang, Q. , Tonks, N. K. (1994) Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. Proceedings of the National Academy of Sciences of the United States of America, 91(21) pp. 9680-9684.

Sun, H., Tonks, N. K. , Barsagi, D. (1994) Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1. Science, 266(5183) pp. 285-288.

Garton, A. J. , Tonks, N. K. (1994) PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation. Embo Journal, 13(16) pp. 3763-3771.

Delvecchio, R. L. , Tonks, N. K. (1994) Characterization of two structurally related Xenopus laevis protein tyrosine phosphatases with homology to lipid-binding proteins. Journal of Biological Chemistry, 269(30) pp. 19639-19645.

Barford, D., Keller, J. C., Flint, A. J. , Tonks, N. K. (1994) Purification and crystallization of the catalytic domain of human protein tyrosine phosphatase 1B expressed in Escherichia coli. Journal of Molecular Biology, 239(5) pp. 726-730.

Tonks, N. K. (1994) Protein tyrosine phosphatases and the control of the cellular signalling responses. Faseb Journal, 8(7) pp. A1377-A1377.

Barford, D., Flint, A. J. , Tonks, N. K. (1994) Crystal structure of human protein tyrosine phosphatase 1B. Science, 263(5152) pp. 1397-1404.

Brady-Kalnay, S. M. , Tonks, N. K. (1994) Protein tyrosine phosphatases: from structure to function. Trends Cell Biol, 4(3) pp. 73-6.

Brady-Kalnay, S. M. , Tonks, N. K. (1993) Purification and characterization of the human protein tyrosine phosphatase, PTP mu, from a baculovirus expression system. Molecular and Cellular Biochemistry, 128 pp. 131-141.

Sun, H., Charles, C. H., Lau, L. F. , Tonks, N. K. (1993) MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell, 75(3) pp. 487-493.

Lammers, R., Bossenmaier, B., Cool, D. E., Tonks, N. K., Schlessinger, J., Fischer, E. H. , Ullrich, A. (1993) Differential activities of protein tyrosine phosphatases in intact cells. Journal of Biological Chemistry, 268(30) pp. 22456-22462.

Brady-Kalnay, S. M., Flint, A. J. , Tonks, N. K. (1993) Homophilic binding of PTP mu, a receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation. Journal of Cell Biology, 122(4) pp. 961-972.

Charles, C. H., Sun, H., Lau, L. F. , Tonks, N. K. (1993) The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the United States of America, 90(11) pp. 5292-5296.

Turner, B. C., Tonks, N. K., Rapp, U. R. , Reed, J. C. (1993) Interleukin-2 Regulates Raf-1 Kinase-Activity through a Tyrosine Phosphorylation-Dependent Mechanism in a T-Cell Line. Proceedings of the National Academy of Sciences of the United States of America, 90(12) pp. 5544-5548.

Flint, A. J., Gebbink, M. F., Franza, B. R., Hill, D. E. , Tonks, N. K. (1993) Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation. Embo Journal, 12(5) pp. 1937-1946.

Potts, M., Sun, H., Mockaitis, K., Kennelly, P. J., Reed, D. , Tonks, N. K. (1993) A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584. Journal of Biological Chemistry, 268(11) pp. 7632-7635.

Yang, Q., Co, D., Sommercorn, J. , Tonks, N. K. (1993) Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase. Journal of Biological Chemistry, 268(9) pp. 6622-6628.

Tonks, N. K., Flint, A. J., Gebbink, M. F., Sun, H. , Yang, Q. (1993) Signal transduction and protein tyrosine dephosphorylation. Adv Second Messenger Phosphoprotein Res, 28 pp. 203-10.

Cool, D. E., Andreassen, P. R., Tonks, N. K., Krebs, E. G., Fischer, E. H. , Margolis, R. L. (1992) Cytokinetic failure and asynchronous nuclear division in BHK cells overexpressing a truncated protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the United States of America, 89(12) pp. 5422-5426.

Ramachandran, C., Aebersold, R., Tonks, N. K. , Pot, D. A. (1992) Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatases. Biochemistry, 31(17) pp. 4232-4238.

Charbonneau, H. , Tonks, N. K. (1992) 1002 Protein Phosphatases?. Annual Review of Cell Biology, 8 pp. 463-493.

Fischer, E. H., Charbonneau, H., Cool, D. E. , Tonks, N. K. (1992) Tyrosine phosphatases and their possible interplay with tyrosine kinases. Ciba Foundation Symposia, 164 pp. 132-144.

Tonks, N. K., Yang, Q., Flint, A. J., Gebbink, M. F., Franza, B. R., Hill, D. E., Sun, H. , Brady-Kalnay, S. M. (1992) Protein tyrosine phosphatases: the problems of a growing family. Cold Spring Harbor Symposia on Quantitative Biology, 57 pp. 87-94.

Sanghera, J. S., McNabb, C. K., Tonks, N. , Pelech, S. L. (1991) Tyrosyl phosphorylation and activation of the myelin basic protein kinase p44mpk during sea star oocyte maturation. Biochimica Et Biophysica Acta, 1095(2) pp. 153-160.

Stover, D. R., Charbonneau, H., Tonks, N. K. , Walsh, K. A. (1991) Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells. Proceedings of the National Academy of Sciences of the United States of America, 88(17) pp. 7704-7707.

Tonks, N. K. (1991) Plague, pox and tyrosine dephosphorylation. Curr Biol, 1(4) pp. 259-61.

Fischer, E. H., Charbonneau, H. , Tonks, N. K. (1991) Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science, 253(5018) pp. 401-406.

McGuire, M. C., Fields, R. M., Nyomba, B. L., Raz, I., Bogardus, C., Tonks, N. K. , Sommercorn, J. (1991) Abnormal regulation of protein tyrosine phosphatase activities in skeletal muscle of insulin-resistant humans. Diabetes, 40(7) pp. 939-942.

Yang, Q. , Tonks, N. K. (1991) Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. Proceedings of the National Academy of Sciences of the United States of America, 88(14) pp. 5949-5953.

Zander, N. F., Lorenzen, J. A., Cool, D. E., Tonks, N. K., Daum, G., Krebs, E. G. , Fischer, E. H. (1991) Purification and characterization of a human recombinant T-cell protein-tyrosine-phosphatase from a baculovirus expression system. Biochemistry, 30(28) pp. 6964-6970.

Tonks, N. K., Diltz, C. D. , Fischer, E. H. (1991) Purification and assay of CD45: an integral membrane protein-tyrosine phosphatase. Methods in Enzymology, 201 pp. 442-451.

Tonks, N. K., Diltz, C. D. , Fischer, E. H. (1991) Purification of protein-tyrosine phosphatases from human placenta. Methods in Enzymology, 201 pp. 427-442.

Tonks, N. K., Yang, Q. , Guida, P. (1991) Structure, regulation, and function of protein tyrosine phosphatases. Cold Spring Harbor Symposia on Quantitative Biology, 56 pp. 265-273.

Tonks, N. K. (1990) Protein phosphatases: key players in the regulation of cell function. Curr Opin Cell Biol, 2(6) pp. 1114-24.