Additional materials of the author at
CSHL Institutional Repository

Safaric Tepes, Polona, Segovia, Danilo, Jevtic, Sania, Ramirez, Daniel, Lyons, Scott K , Sordella, Raffaella (2021) Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma. Laboratory Investigation,

Šafarič Tepeš, Polona , Sordella, Raffaella (2021) A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization.. Journal of Visualized Experiments, (175)

Safaric Tepes, Polona, Pal, Debjani, Lindsted, Trine, Ibarra, Ingrid, Lujambio, Amaia, Jimenez Sabinina, Vilma, Senturk, Serif, Miller, Madison, Korimerla, Navya, Huang, Jiahao, Glassman, Lawrence, Lee, Paul, Zeltsman, David, Hyman, Kevin, Esposito, Michael, Hannon, Greg , Sordella, Raffaella (2021) An epigenetic switch regulates the ontogeny of AXL positive/EGFR-TKI resistant cells by modulating miR-335 expression. eLife, 10

Chen, M., Nowak, D. G., Narula, N., Robinson, B., Watrud, K., Ambrico, A., Herzka, T. M., Zeeman, M. E., Minderer, M., Zheng, W., Ebbesen, S. H., Plafker, K. S., Stahlhut, C., Wang, V. M., Wills, L., Nasar, A., Castillo-Martin, M., Cordon-Cardo, C., Wilkinson, J. E., Powers, S., Sordella, R., Altorki, N. K., Mittal, V., Stiles, B. M., Plafker, S. M. , Trotman, L. C. (2017) The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. J Cell Biol, 216(3) pp. 641-656.

Senturk, S., Shirole, N. H., Nowak, D. G., Corbo, V., Pal, D., Vaughan, A., Tuveson, D. A., Trotman, L. C., Kinney, J. B. , Sordella, R. (2017) Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization. Nat Commun, 8 pp. 14370.

Pal, D., Pertot, A., Shirole, N. H., Yao, Z., Anaparthy, N., Garvin, T., Cox, H., Chang, K., Rollins, F., Kendall, J., Edwards, L., Singh, V. A., Stone, G. C., Schatz, M. C., Hicks, J., Hannon, G. , Sordella, R. (2017) TGF-beta reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells. Elife, 6

Miller, M., Shirole, N., Tian, R., Pal, D. , Sordella, R. (2016) The Evolution of TP53 Mutations: From Loss-of-Function to Separation-of-Function Mutants. J Cancer Biol Res, 4(4)

Shirole, N. H., Pal, D., Kastenhuber, E. R., Senturk, S., Boroda, J., Pisterzi, P., Miller, M., Munoz, G., Anderluh, M., Ladanyi, M., Lowe, S. W. , Sordella, R. (2016) TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions. Elife, 5

Gerhard, D. S., Clemons, P. A., Shamji, A. F., Hon, C., Wagner, B. K., Schreiber, S. L., Krasnitz, A., Sordella, R., Sander, C., Lowe, S. W., Powers, S., Smith, K., Aburi, M., Iavarone, A., Lasorella, A., Silva, J., Stockwell, B. R., Califano, A., Boehm, J. S., Vazquez, F., Weir, B. A., Hahn, W. C., Khuri, F. R., Moreno, C. S., Johns, M., Fu, H., Nikolova, O., Mendez, E., Gadi, V. K., Margolin, A. A., Grandori, C., Kemp, C. J., Warren, E. H., Riddell, S. R., McIntosh, M. W., Gevaert, O., Kuo, C. J., Ji, H. P., Dhruv, H., Finlay, D., Kiefer, J., Kim, S., Vuori, K., Berens, M. E., Hangauer, M., Boettcher, M., Weissman, J. S., Bivona, T. G., Bandyopadhyay, S., McManus, M. T., McCormick, F., Aksoy, O., Simonds, E. F., Zheng, T., Chen, J., An, Z., Balmain, A., Weiss, W. A., Chen, K., Liang, H., Scott, K. L., Mills, G. B., Posner, B. A., MacMillan, J., Minna, J., White, M., Roth, M. G., Jagu, S. , Mazerik, J. (2016) Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Mol Cancer Res,

Li, J., Sordella, R. , Powers, S. (2016) Effectors and potential targets selectively upregulated in human KRAS-mutant lung adenocarcinomas. Sci Rep, 6 pp. 27891.

Trotman, L. C., Nowak, D. G., Cho, H., Herzka, T., Watrud, K., DeMarco, D. V., Wang, V. M., Senturk, S., Fellmann, C., Ding, D., Beinortas, T., Kleinman, D., Chen, M., Sordella, R., Wilkinson, J. E., Castillo-Martin, M., Cordon-Cardo, C. , Robinson, B. D. (2015) Myc drives Pten/trp53-deficient proliferation and metastasis due to Il6-secretion and Akt-suppression via Phlpp2. Cancer Discovery, 5(6) pp. 636-651.

Agrusa, C. J., Sordella, R., Paul, S., Lee, P. C., Port, J., Altorki, N. K. , Stiles, B. M. (2014) A Novel Platform for Proteomic Analysis of Proximal Source Pulmonary Venous Blood Identifies Potential Biomarkers for Non-Small Cell Lung Cancer (NSCLC). Journal of the American College of Surgeons, 219(3 Supp) pp. S37-S37.

Coppolino, A., Agrusa, C. J., Kajno, E., Ryu, S., Sordella, R., Altorki, N. K. , Stiles, B. M. (2014) Bone Marrow Induces STAT3 Pathway Activation in a Model of Disseminated Non-Small Cell Lung Cancer Cells. Journal of the American College of Surgeons, 219(3 Supp) pp. S31-S31.

Senturk, S., Yao, Z., Camiolo, M., Stiles, B., Rathod, T., Walsh, A. M., Nemajerova, A., Lazzara, M. J., Altorki, N. K., Krainer, A., Moll, U. M., Lowe, S. W., Cartegni, L. , Sordella, R. (2014) p53Psi is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proceedings of the National Academy of Sciences of the United States of America, 111(32) pp. E3287-E3296.

Holembowski, L., Kramer, D., Riedel, D., Sordella, R., Nemajerova, A., Dobbelstein, M. , Moll, U. M. (2014) Tap73 is essential for germ cell adhesion and maturation in testis. Journal of Cell Biology, 204(7) pp. 1173-1190.

Chaudhri, V. K., Salzler, G. G., Dick, S. A., Buckman, M. S., Sordella, R., Karoly, E. D., Mohney, R., Stiles, B. M., Elemento, O., Altorki, N. K. , McGraw, T. E. (2013) Metabolic Alterations in Lung Cancer-Associated Fibroblasts Correlated with Increased Glycolytic Metabolism of the Tumor. Molecular Cancer Research, 11(6) pp. 579-592.

Abera, M., Sordella, R. , Kazanietz, M. (2013) PKC alpha is implicated in epithelial to mesenchymal transition and erlotinib resistance in non-small cell lung carcinoma cells. Cancer Research, 73(8 (Sup) pp. 5261.

Coppolino, A., Gao, D. C., Wagner, P. L., Sordella, R., Mittal, V., Altorki, N. K. , Stiles, B. M. (2012) Standard markers for detection of circulating tumor cells are variably expressed in pulmonary adenocarcinomas and are downregulated in cells undergoing mesenchymal transition. Journal of the American College of Surgeons, 215(3) pp. S40-S40.

Kani, K., Sordella, R. , Mallick, P. (2012) Investigation of acquired resistance to EGFR-targeted therapies in lung cancer using cDNA microarrays. Methods in Molecular Biology, 795 pp. 233-53.

Premsrirut, P. K., Dow, L. E., Kim, S. Y., Camiolo, M., Malone, C. D., Miething, C., Scuoppo, C., Zuber, J., Dickins, R. A., Kogan, Scott C, Shroyer, Kenneth R, Sordella, R., Hannon, G. J. , Lowe, S. W. (2011) A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference. Cell, 145(1) pp. 145-158.

Schreiber, S. L., Shamji, A. F., Clemons, P. A., Hon, C., Koehler, A. N., Munoz, B., Palmer, M., Stern, A. M., Wagner, B. K., Powers, S., Lowe, S. W., Guo, X., Krasnitz, A., Sawey, E. T., Sordella, R., Stein, L. D., Trotman, L. C., Califano, A., Dalla-Favera, R., Ferrando, A., Iavarone, A., Pasqualucci, L., Silva, J., Stockwell, B. R., Hahn, W. C., Chin, L., DePinho, R. A., Boehm, J. S., Gopal, S., Huang, A., Root, D. E., Weir, B. A., Gerhard, D. S., Zenklusen, J. C., Roth, M. G., White, M. A., Minna, J. D., MacMillan, J. B. , Posner, B. A. (2010) Towards patient-based cancer therapeutics. Nature Biotechnology, 28(9) pp. 904-906.

Yao, Z., Fenoglio, S., Gao, D. C., Camiolo, M., Stiles, B., Lindsted, T., Schlederer, M., Johns, C., Altorki, N., Mittal, V., Kenner, L. , Sordella, R. (2010) TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proceedings of the National Academy of Sciences of the United States of America, 107(35) pp. 15535-40.

Bell, D. W., Brannigan, B. W., Matsuo, K., Finkelstein, D. M., Sordella, R., Settleman, J., Mitsudomi, T. , Haber, D. A. (2008) Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms. Clinical Cancer Research, 14(13) pp. 4079-84.

Xue, W., Krasnitz, A., Lucito, R., Sordella, R., Van Aelst, L., Cordon-Cardo, C., Singer, S., Kuehnel, F., Wigler, M. H., Powers, S., Zender, L. , Lowe, S. W. (2008) DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development, 22(11) pp. 1439-44.

Sordella, R. , Van Aelst, L. (2008) Dialogue between RhoA/ROCK and Members of the Par Complex in Cell Polarity. Developmental Cell, 14(2) pp. 150-2.

McDermott, U., Sharma, S. V., Dowell, L., Greninger, P., Montagut, C., Lamb, J., Archibald, H., Raudales, R., Tam, A., Lee, D., Rothenberg, S. M., Supko, J. G., Sordella, R., Ulkus, L. E., Iafrate, A. J., Maheswaran, S., Njauw, C. N., Tsao, H., Drew, L., Hanke, J. H., Ma, X. J., Erlander, M. G., Gray, N. S., Haber, D. A. , Settleman, J. (2007) Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proceedings of the National Academy of Sciences of the United States of America, 104(50) pp. 19936-41.

Mulloy, R., Ferrand, A., Kim, Y., Sordella, R., Bell, D. W., Haber, D. A., Anderson, K. S. , Settleman, J. (2007) Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib. Cancer Research, 67(5) pp. 2325-30.

Smolen, G. A., Sordella, R., Muir, B., Mohapatra, G., Barmettler, A., Archibald, H., Kim, W. J., Okimoto, R. A., Bell, D. W., Sgroi, D. C., Christensen, J. G., Settleman, J. , Haber, D. A. (2006) Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proceedings of the National Academy of Sciences of the United States of America, 103(7) pp. 2316-21.

Bell, D. W., Sordella, R., Kwak, E. L., Godin-Heymann, N., Sharma, S. V., Sgroi, D. C., Sequist, L. V., Lynch, T. J., Settleman, J. , Haber, D. A. (2006) Molecular targeted therapy of lung cancer. Tumor Biology, 27(Suppl)

Matheson, S. F., Hu, K. Q., Brouns, M. R., Sordella, R., VanderHeide, J. D. , Settleman, J. (2006) Distinct but overlapping functions for the closely related p190 RhoGAPs in neural development. Developmental Neuroscience, 28(6) pp. 538-50.

Sordella, R. , Van Aelst, L. (2006) Driving Actin Dynamics under the Influence of Alcohol. Cell, 127(1) pp. 37-39.

Bell, D. W., Gore, I., Okimoto, R. A., Godin-Heymann, N., Sordella, R., Mulloy, R., Sharma, S. V., Brannigan, B. W., Mohapatra, G., Settleman, J. , Haber, D. A. (2005) Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR. Nature Genetics, 37(12) pp. 1315-6.

Barberis, D., Casazza, A., Sordella, R., Corso, S., Artigiani, S., Settleman, J., Comoglio, P. M. , Tamagnone, L. (2005) p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling. Journal of Cell Science, 118(Pt 20) pp. 4689-700.

Sordella, R., Jiang, W., Ligeti, E. , Settleman, J. (2005) Regulation of p190 RhoGAP function. Febs Journal, 272 pp. 324-324.

Kwak, E. L., Sordella, R., Bell, D. W., Godin-Heymann, N., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Driscoll, D. R., Fidias, P., Lynch, T. J., Rabindran, S. K., McGinnis, J. P., Wissner, A., Sharma, S. V., Isselbacher, K. J., Settleman, J. , Haber, D. A. (2005) Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proceedings of the National Academy of Sciences of the United States of America, 102(21) pp. 7665-70.

Jiang, W., Sordella, R., Chen, G. C., Hakre, S., Roy, A. L. , Settleman, J. (2005) An FF domain-dependent protein interaction mediates a signaling pathway for growth factor-induced gene expression. Molecular Cell, 17(1) pp. 23-35.

Haber, D. A., Bell, D. W., Sordella, R., Kwak, E. L., Godin-Heymann, N., Sharma, S. V., Lynch, T. J. , Settleman, J. (2005) Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors. Cold Spring Harbor Symposia on Quantitative Biology, 70 pp. 419-26.

Sordella, R., Bell, D. W., Haber, D. A. , Settleman, J. (2004) Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science, 305(5687) pp. 1163-7.

Kontaridis, M. I., Eminaga, S., Fornaro, M., Zito, C. I., Sordella, R., Settleman, J. , Bennett, A. M. (2004) SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Molecular and Cellular Biology, 24(12) pp. 5340-52.

Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., Louis, D. N., Christiani, D. C., Settleman, J. , Haber, D. A. (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. The New England Journal of Medicine, 350(21) pp. 2129-39.

Sordella, R., Jiang, W., Chen, G. C., Curto, M. , Settleman, J. (2003) Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell, 113(2) pp. 147-58.

Yajnik, V., Paulding, C., Sordella, R., McClatchey, A. I., Saito, M., Wahrer, D. C., Reynolds, P., Bell, D. W., Lake, R., van den Heuvel, S., Settleman, J. , Haber, D. A. (2003) DOCK4, a GTPase activator, is disrupted during tumorigenesis. Cell, 112(5) pp. 673-84.

Sordella, R., Classon, M., Hu, K. Q., Matheson, S. F., Brouns, M. R., Fine, B., Zhang, L., Takami, H., Yamada, Y. , Settleman, J. (2002) Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development. Developmental Cell, 2(5) pp. 553-65.

Sordella, R., Classon, M., Hu, K. Q., Matheson, S., Brouns, M., Fine, B., Yamada, Y. , Settleman, J. (2001) Modulation of CREB activity by the Rho GTPase determines cell size during embryonic development. Molecular Biology of the Cell, 12(Supple) pp. 401A-402A.

Walhout, A. J., Sordella, R., Lu, X., Hartley, J. L., Temple, G. F., Brasch, M. A., Thierry-Mieg, N. , Vidal, M. (2000) Protein interaction mapping in C. elegans using proteins involved in vulval development. Science, 287(5450) pp. 116-22.